Description

Myfortic 360mg 120’ct Tab Imported is a medication used in combination with other drugs to prevent the body from rejecting a transplanted organ, such as a kidney, liver, or heart. It is an immunosuppressant drug that works by reducing the activity of the body’s immune system.The typical dosage of Myfortic 360mg is 720mg taken twice daily. It is available as a delayed-release tablet that is taken with food. Myfortic is an imported medication in Pakistan and can be purchased online from various pharmacies

Formulation

• Myfortic is the brand name for the active ingredient mycophenolic acid (MPA)
• It is formulated as a delayed-release tablet to protect the active ingredient from stomach acid
• The delayed-release allows the MPA to be absorbed in the intestines

Mechanism of Action

• Myfortic works by inhibiting an enzyme called inosine monophosphate dehydrogenase (IMPDH)
• This enzyme is crucial for the proliferation of lymphocytes, a type of white blood cell involved in immune responses
• By inhibiting IMPDH, Myfortic reduces the ability of the immune system to mount a rejection response against the transplanted organ

Dosing

• The recommended dose of Myfortic is 720mg taken twice daily, for a total daily dose of 1440mg
• This high dose is necessary to achieve sufficient levels of the active metabolite MPA in the body
• The delayed-release formulation allows for more consistent MPA levels compared to the original mycophenolate mofetil formulation

Advantages

• Myfortic has improved gastrointestinal tolerability compared to the older mycophenolate mofetil formulation
• The delayed-release design reduces the risk of stomach irritation and ulcers
• Myfortic has been shown to be effective in preventing acute rejection in kidney, liver and heart transplant recipients
  

  Key Benefits

  • Used to prevent rejection of transplanted organs such as kidney, liver or heart
  • Works by suppressing the immune system to prevent it from attacking the transplanted organ
  • Delayed-release formulation allows for more consistent absorption and levels of the active ingredient
  • Has improved gastrointestinal tolerability compared to older mycophenolate mofetil formulations

  Key Ingredients

  • The active ingredient is mycophenolic acid (MPA)
  • MPA is a potent, selective, uncompetitive and reversible inhibitor of the enzyme inosine monophosphate dehydrogenase (IMPDH)
  • Inhibiting IMPDH reduces the ability of lymphocytes (white blood cells) to proliferate, thereby suppressing the immune response
  • Each Myfortic 360mg tablet also contains 90mg of the excipient lactose
  

  Mycophenolic acid

  Immunosuppressant medication used for organ transplantation and autoimmune conditions

  More

  Trade Names

  Cellcept, Myfortic, others

  Common Side Effects

  Nausea, infections, diarrhea

  Medical Use

  Prevent organ rejection post-transplantation, treat autoimmune diseases like Crohn’s and lupus

  Mycophenolic acid works in the body by inhibiting the enzyme inosine monophosphate dehydrogenase (IMPDH), which is essential for the de novo synthesis of guanosine monophosphate (GMP) from inosine monophosphate (IMP) .The key points about how mycophenolic acid works are:

  • Mycophenolic acid is a potent, reversible, and non-competitive inhibitor of IMPDH .
  • IMPDH is a crucial enzyme for the de novo synthesis of guanosine, which is required for the proliferation of lymphocytes (T cells and B cells) .
  • By inhibiting IMPDH, mycophenolic acid selectively targets the proliferation of lymphocytes, which rely almost exclusively on the de novo purine synthesis pathway .
  • Other cell types can utilize an alternative salvage pathway to obtain purines, and thus are less affected by IMPDH inhibition .
  • This selective inhibition of lymphocyte proliferation is the mechanism by which mycophenolic acid exerts its immunosuppressive effects, preventing rejection of transplanted organs 

Mycophenolic acid, the active ingredient in Myfortic, works by inhibiting the enzyme inosine monophosphate dehydrogenase (IMPDH):

• Mycophenolic acid is a potent, selective, uncompetitive and reversible inhibitor of IMPDH .
• IMPDH is a crucial enzyme for the de novo synthesis of guanosine monophosphate (GMP) from inosine monophosphate (IMP) .
• The de novo purine synthesis pathway that relies on IMPDH is essential for the proliferation of lymphocytes (T cells and B cells) .
• By inhibiting IMPDH, mycophenolic acid selectively targets the proliferation of lymphocytes, which rely almost exclusively on the de novo purine synthesis pathway .
• Other cell types can utilize an alternative salvage pathway to obtain purines, and thus are less affected by IMPDH inhibition .
• This selective inhibition of lymphocyte proliferation is the mechanism by which mycophenolic acid exerts its immunosuppressive effects, preventing rejection of transplanted organs
  

  Dosage

  • The recommended daily dose of Myfortic is 1440mg, taken as 720mg twice daily 
  • The first dose should be given within 72 hours after transplantation 
  • For patients with severe kidney problems, the daily dose should not exceed 1440mg 
  • Myfortic tablets should be swallowed whole and not crushed or broken 

  Storage

  • Myfortic tablets should be stored at temperatures below 30°C 
  • Keep the tablets out of reach of children 
  • No special temperature storage conditions are required 

  Reviews

  • There are no specific reviews available for the imported 120 count version of Myfortic 360mg tablets
  • However, the Myfortic brand in general has been widely used and studied for prevention of organ transplant rejection 
  • It is considered an effective immunosuppressant medication with a favorable safety profile when used as directed by transplant specialists