Topamax 25mg 50’ct
Topamax 25 mg tablets are used to treat seizures in adults and children over 6 years old, either alone or in combination with other medications. The recommended starting dose is 25-50 mg once daily at bedtime for one week, followed by weekly increases of 25-50 mg taken in two divided doses to achieve the optimal therapeutic effect.Each Topamax 25 mg film-coated tablet contains 25 mg of topiramate as the active ingredient, along with excipients like lactose monohydrate. The tablets are white, round, 6 mm in diameter, with “TOP” on one side and “25” on the other.Topamax 25 mg tablets are available in 50-count bottles. They should be stored at room temperature, protected from light and moisture, and kept out of reach of children. Patients should drink plenty of fluids while taking Topamax to prevent kidney stones
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Description
Topamax 25 mg tablets are used to treat seizures in adults and children over 6 years old, either alone or in combination with other medications. The recommended starting dose is 25-50 mg once daily at bedtime for one week, followed by weekly increases of 25-50 mg taken in two divided doses to achieve the optimal therapeutic effect.Each Topamax 25 mg film-coated tablet contains 25 mg of topiramate as the active ingredient, along with excipients like lactose monohydrate. The tablets are white, round, 6 mm in diameter, with “TOP” on one side and “25” on the other.Topamax 25 mg tablets are available in 50-count bottles. They should be stored at room temperature, protected from light and moisture, and kept out of reach of children. Patients should drink plenty of fluids while taking Topamax to prevent kidney stones.
Indication
- Topamax 25 mg tablets are used to treat seizures in adults and children over 6 years old, either alone or in combination with other medications.
Dosage
- The recommended starting dose is 25-50 mg once daily at bedtime for one week.
- The dose is then increased weekly by 25-50 mg, taken in two divided doses, to achieve the optimal therapeutic effect.
Tablet Composition
- Each Topamax 25 mg film-coated tablet contains 25 mg of topiramate as the active ingredient.
- The tablets also contain excipients like lactose monohydrate.
Appearance
- The tablets are white, round, 6 mm in diameter, with “TOP” on one side and “25” on the other.
Packaging
- Topamax 25 mg tablets are available in 50-count bottles.
Storage
- Store at room temperature, protected from light and moisture.
- Keep out of reach of children.
- Patients should drink plenty of fluids while taking Topamax to prevent kidney stones.
Key Benefits of Topamax 25 mg Tablets
- Treats seizures in adults and children over 6 years old, either alone or in combination with other medications
- Prevents migraine headaches in adults and children aged 12 years and older
- Available in 50-count bottles for convenient dosing
Key Ingredients
- Each Topamax 25 mg film-coated tablet contains 25 mg of topiramate as the active ingredient
- The tablets also contain excipients like lactose monohydrate
Mechanism of Action
The precise mechanisms by which topiramate (the active ingredient in Topamax) exerts its anticonvulsant and migraine prophylaxis effects are unknown. However, preclinical studies have suggested several potential mechanisms:
- Inhibition of voltage-gated sodium channels
- Enhancement of gamma-aminobutyrate (GABA)-activated chloride channels
- Antagonism of AMPA/kainate subtypes of glutamate receptors
- Inhibition of the carbonic anhydrase enzyme
The inhibition of voltage-gated sodium channels and enhancement of GABA-activated chloride channels likely contribute to the anticonvulsant effects of topiramate. The antagonism of AMPA/kainate subtypes of glutamate receptors may also play a role in preventing seizures and migraines.Topiramate’s inhibition of the carbonic anhydrase enzyme can lead to metabolic acidosis, which is a potential side effect of the medication. This inhibition may also contribute to the drug’s anticonvulsant properties, although the exact relationship is not fully understood.It is important to note that while these potential mechanisms have been identified, the precise ways in which topiramate exerts its therapeutic effects are still under investigation and not fully elucidated
Topiramate should generally be avoided during pregnancy due to the risks of congenital malformations and neurodevelopmental disorders in the baby:
- Multiple studies have shown a 2- to 5-fold increased risk of oral clefts (cleft lip and palate) in infants after maternal use of topiramate early in pregnancy. The risk is more pronounced at higher doses used to treat epilepsy.
- Children prenatally exposed to topiramate have a higher chance of autism spectrum disorder (ASD) or intellectual disability compared to the general population. Around 3 in 100 exposed children may be diagnosed with ASD, compared to 1 in 100 in the background population.
- Topiramate can also cause fetal growth restriction when used during pregnancy.
Dosage
Monotherapy for Epilepsy
- The recommended maintenance dose for adults and children 10 years and older is 400 mg/day in two divided doses, titrated over 6 weeks
- For children 2-9 years, the dose is weight-based, starting at 25 mg/day and titrated up to a maximum of 400 mg/day
Adjunctive Therapy for Epilepsy
- The recommended dose for adults is 200-400 mg/day in two divided doses, titrated over several weeks
- For children 2-16 years, the dose is approximately 5-9 mg/kg/day in two divided doses, titrated over several weeks
Migraine Prevention
- The recommended dose for adults and children 12 years and older is 100 mg/day in two divided doses, titrated over 4 weeks
Storage
- Store Topamax 25 mg tablets at room temperature, 59°F to 86°F (15°C to 30°C)
- Keep the tablets in a tightly closed container and protect from moisture
- Keep Topamax and all medicines out of reach of children
Key Information
- Topamax 25 mg tablets contain 25 mg of the active ingredient topiramate, along with excipients like lactose monohydrate
- The tablets are white, round, and debossed with “TOP” on one side and “25” on the other
- Topamax is available in 50-count bottles
- Patients should drink plenty of fluids while taking Topamax to prevent kidney stones
Reviews
- Topamax has been effective in preventing migraines and reducing migraine-related vomiting for some patients.
- It can lead to weight loss by reducing appetite and food cravings.
- Some patients report no side effects while taking Topamax.
Reviews
There are no reviews yet.