Description

Dactinomycin 0.5 mg Injection is an anti-cancer medication used to treat various types of cancer in Pakistan. It is available under the brand name K.U. Dactinomycin and is marketed by Al Habib Pharmaceuticals.The injection is typically sold in 1 vial packs and costs between Rs. 204 to Rs. 292 in Pakistan. It is used to treat conditions like Wilm’s Tumor, a type of kidney cancer in children. Dactinomycin is a chemotherapy drug that works by interfering with cell division and growth, thereby killing cancer cells.

Mechanism of Action

Dactinomycin is an antitumor antibiotic that binds to DNA and inhibits RNA synthesis, leading to cell death. It is particularly effective against rapidly dividing cells like cancer cells.

Indications

In Pakistan, Dactinomycin is primarily used to treat Wilm’s Tumor, a type of kidney cancer that mainly affects children. It is also used for other cancers like rhabdomyosarcoma, Ewing’s sarcoma, and gestational trophoblastic neoplasia.

Administration

Dactinomycin is administered intravenously as an injection. The dosage and frequency depend on the type of cancer, patient’s age, and response to treatment. It is usually given in combination with other chemotherapy drugs.

Side Effects

Common side effects include nausea, vomiting, diarrhea, mouth sores, hair loss, and increased risk of infections. Severe side effects like liver damage and allergic reactions can also occur.

Availability and Cost

K.U. Dactinomycin 0.5 mg Injection is available in Pakistan . The cost ranges from Rs. 204 to Rs. 292 per 1 vial pack.

Precautions

Dactinomycin should be used with caution in patients with liver or kidney disease, and its use may be restricted during pregnancy and breastfeeding. Regular monitoring of blood counts and liver function is necessary during treatment.

Key Benefits

• Effective against specific cancers like Wilms tumor, rhabdomyosarcoma, Ewing’s sarcoma, testicular cancer, and gestational trophoblastic neoplasia
• Used as part of combination chemotherapy regimens to treat various types of cancer
• Inhibits the growth and division of cancer cells, leading to their death

Key Ingredients

• Active ingredient: Dactinomycin, an antibiotic derived from Streptomyces bacteria
• Excipients: Mannitol USP (20 mg per vial)

Dosage

• Varies by cancer type and whether used alone or in combination
• Typical doses range from 15-1250 mcg/kg or mcg/m2, given IV

Storage

• Store at 20-25°C (68-77°F)
• Reconstituted vials must be used within 4 hours
  

  Reviews

  • K.U. Dactinomycin 0.5 mg Injection is marketed in Pakistan by Vitamins collection.com.
  • The cost ranges from Rs. 983.70 to Rs. 1,093.00 per 1 vial pack.
  • No specific reviews were found for the K.U. brand in Pakistan. However, dactinomycin is an established chemotherapy drug used to treat various cancers worldwide.