Description

Humlaog Mix 25 Insulin Pen 5’ct Imported from Turkey is a medication used to control high blood sugar (glucose) in people with diabetes mellitus.It is a mixture of fast-acting insulin lispro and long-acting insulin lispro protamine, which is a man-made insulin analogue. Humalog Mix 25 takes effect more rapidly and has a shorter duration of activity compared to regular insulin.The recommended dosage is Insulin Lispro + Insulin Lispro Protamine. Common side effects include hypoglycemia (low blood sugar), diabetic acidosis and coma, lipoatrophy (depression in the skin), lipohypertrophy (enlargement or thickening of tissue), and allergic reactions at the injection site.Humalog Mix 25 should be administered by subcutaneous injection only, within 15 minutes before a meal, and any changes to the insulin regimen should be made cautiously under medical supervision. It is not recommended for patients experiencing an episode of low blood sugar or with an allergy to Humalog or its ingredients

Insulin Mixture Composition

• Humalog Mix 25 is a combination of 25% insulin lispro (rapid-acting) and 75% insulin lispro protamine (intermediate-acting).
• The rapid-acting insulin provides quick control of blood sugar levels after meals, while the intermediate-acting insulin provides a more prolonged effect to help maintain blood sugar levels between meals and overnight.

Pen Injector Device

• The Humalog Mix 25 is pre-filled in a disposable pen injector device.
• The pen allows for easy and accurate dosing in 0.5 unit increments up to 30 units per injection.
• The pen is designed for single-patient use and should be discarded when empty.

Imported from Turkey

• This particular Humalog Mix 25 is imported from Turkey, which may have some unique packaging or labeling compared to versions available in other countries.
• The importation from Turkey could potentially impact availability or pricing compared to locally sourced versions.

Dosage and Administration

• Humalog Mix 25 should be dosed based on individual patient needs, as determined by a healthcare provider.
• It is typically administered subcutaneously (under the skin) within 15 minutes before a meal.
• Proper injection technique and rotation of injection sites is important for optimal efficacy and to minimize side effects.

Unique Considerations

• Patients using Humalog Mix 25 should closely monitor their blood sugar levels and be prepared to treat hypoglycemia (low blood sugar) if it occurs.
• The insulin mixture may need to be adjusted based on factors such as diet, exercise, illness, stress, or changes in kidney or liver function.
• Proper storage and handling of the insulin pens is important to maintain potency and avoid contamination.                                                                                                                            The mechanism of action for Humalog Mix 25 Insulin Pen is as follows:Humalog Mix 25 is a combination of 25% rapid-acting insulin lispro and 75% intermediate-acting insulin lispro protamine suspension. This combination provides both rapid and prolonged glucose-lowering effects:
  • The insulin lispro component has a rapid onset of action, reaching peak activity within 1-2 hours after injection. This helps lower blood sugar levels quickly after meals.
  • The insulin lispro protamine suspension component has an intermediate duration of action, lowering blood sugar levels over a more prolonged period of 18 hours or more. This helps maintain blood sugar control between meals and overnight.

  The rapid-acting insulin lispro component works by:

  • Stimulating peripheral glucose uptake, especially by skeletal muscle and fat tissue
  • Inhibiting hepatic glucose production

  The intermediate-acting insulin lispro protamine suspension component provides a more gradual and sustained glucose-lowering effect.Together, the combination of rapid-acting and intermediate-acting insulins in Humalog Mix 25 helps achieve better glycemic control by mimicking the body’s natural insulin response to meals and providing basal insulin coverage throughout the day and night.                                                                                                    The chemical structure of the insulin components in Humalog Mix 25 Insulin Pen is as follows:

  Insulin Lispro

  • Insulin lispro is a rapid-acting insulin analogue that is structurally identical to human insulin, except for two amino acid changes at positions 28 and 29 on the B-chain .
  • The empirical formula for insulin lispro is C257H383N65O77S6 and it has a molecular weight of 5,808 .
  • The structural formula shows that insulin lispro has the amino acids lysine (Lys) at position 28 and proline (Pro) at position 29 on the B-chain, whereas human insulin has the reverse sequence of Pro at 28 and Lys at 29 .

  Insulin Lispro Protamine

  • Insulin lispro protamine is an intermediate-acting insulin suspension that contains insulin lispro crystalized with protamine .
  • The protamine component helps slow the absorption and prolong the duration of action of the insulin lispro .

  The combination of 25% rapid-acting insulin lispro and 75% intermediate-acting insulin lispro protamine suspension in Humalog Mix 25 provides both quick and sustained glucose-lowering effects to help manage blood sugar levels.

Insulin lispro

Modified type of medical insulin used to treat diabetes

More

Trade names

Humalog, Liprolog, Admelog, others

Onset of effects

Within 30 minutes

Duration of effects

Lasts about 5 hours