Description

The Apidra Insulin Pen 5’ct Imported Turkey is a fast-acting insulin product used to control high blood sugar levels in adults and children with diabetes. It is imported from Turkey and sold in packages of 5 pens.The key details about this product are:

• Apidra is a rapid-acting insulin that can be taken within 15 minutes before or 20 minutes after starting a meal.
• The Apidra Insulin Pen 5’ct is imported from Turkey and sold in packages of 5 pens.
• The original price of the 5-pen package was ₨4,999.00, but the current price is $17.94 (₨18,999.00).
• Apidra is approved for use in both adults and children with diabetes to help manage blood sugar levels
  

  Rapid-Acting Insulin

  Apidra is a rapid-acting insulin analog, meaning it starts working faster and has a shorter duration of action compared to regular human insulin. This can provide better blood sugar control, especially around mealtimes.

  Convenient Pen Delivery

  The Apidra Insulin Pen is a prefilled, disposable pen that makes it easy to accurately dose and administer the insulin. This can be more convenient than drawing up insulin from a vial.

  Imported from Turkey

  This particular package of Apidra insulin pens is imported from Turkey, which may make it more accessible or affordable for some patients compared to purchasing it directly from the manufacturer.

  Smaller Package Size

  The 5-pen package size is unique, as Apidra is often sold in larger quantities like 10 or 15 pens per box. The smaller 5-pen size could be beneficial for patients who need a more portable or trial-sized option.

  Potential Benefits

  The rapid-acting nature, pen delivery, and imported source of this Apidra product may provide advantages for some patients in terms of convenience, flexibility, and cost-effectiveness in managing their diabetes.

  Key Benefits

  • Rapid-acting insulin that starts working within 10-20 minutes and peaks in about 1 hour, providing better blood sugar control around mealtimes 
  • Convenient pen delivery system makes it easy to accurately dose and administer the insulin 
  • Imported from Turkey, which may make it more accessible or affordable for some patients 
  • Smaller 5-pen package size provides more flexibility and portability compared to larger box sizes 

  Key Ingredient

  • The active ingredient in the Apidra Insulin Pen is insulin glulisine, a rapid-acting insulin analog that is equivalent in potency to regular human insulin 

  Mechanism of Action

  Apidra (insulin glulisine) is a rapid-acting insulin analog that works by:

  • Binding to the insulin receptor, a heterotetrameric protein consisting of two extracellular alpha units and two transmembrane beta units .
  • This binding activates the insulin receptor’s tyrosine kinase activity, triggering a signaling cascade that promotes glucose uptake in skeletal muscle and fat tissue, while inhibiting glucose production in the liver .
  • The structural modifications in insulin glulisine, compared to regular human insulin, decrease hexamer formation and stabilize the insulin monomers. This increases the rate of absorption and onset of action compared to human insulin .
  • Apidra begins to exert its effects within 15 minutes of subcutaneous administration, with peak levels occurring 30-90 minutes after injection. Its duration of action is around 5 hours, making it a “bolus insulin” that provides high levels of insulin for a short period to mimic the pancreas’ natural insulin release after meals .
  

  Insulin glulisine

  Rapid-acting modified insulin

  More

  Definition

  A rapid-acting modified form of insulin with amino acid substitutions for improved pharmacokinetics.

  Trade Name

  Apidra, Apidra SoloStar

  Developed by

  Sanofi-Aventis

  The chemical structure of insulin glulisine, the active ingredient in Apidra insulin, is:

  11 A-chain Phe Asn S Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys S S S S S S S S Val Lys Gln His Leu Gly Phe Tyr Cys Gly Ser Glu Arg His Leu Val Glu Ala Leu Val Cys Gly Thr Pro Glu Thr Tyr Leu Phe S 29 3 B-chain


  Insulin glulisine differs from human insulin in that the amino acid asparagine at position B3 is replaced by lysine and the lysine in position B29 is replaced by glutamic acid. Chemically, insulin glulisine is 3B-lysine-29B-glutamic acid-human insulin, has the empirical formula C258H384N64O78S6 and a molecular weight of 5823.The structural modifications in insulin glulisine, compared to regular human insulin, decrease hexamer formation and stabilize the insulin monomers. This increases the rate of absorption and onset of action compared to human insulin.

  Dosage

  • Apidra is a rapid-acting insulin that should be taken within 15 minutes before or 20 minutes after starting a meal 
  • Apidra can be used alone or in combination with other longer-acting insulins as part of a diabetes management regimen 
  • The recommended dosage is individualized based on the patient’s needs and blood sugar levels 

  Storage

  • The Apidra Insulin Pens should be stored refrigerated at 36°F to 46°F (2°C to 8°C) 
  • Once in use, the pens can be kept at room temperature (up to 86°F/30°C) for up to 28 days 
  • The pens and infusion sets should be discarded after no more than 2 days of use or if exposed to temperatures over 98.6°F (37°C) 

  Reviews

  • There are no user reviews available for the specific Apidra Insulin Pen 5’ct Imported Turkey product 
  • However, Apidra as a medication has generally positive reviews, with patients reporting it helps improve blood sugar control around meals