Description

Nandrolone decanoate is an anabolic steroid indicated for the management of anemia of renal insufficiency and as an adjunct therapy in the treatment of osteoporosis.The key points about Nandrolone Decanoate Injection 100 mg/1 mL are:

• It is administered by deep intramuscular injection, typically into the gluteal muscle.
• The recommended dosage for anemia of renal disease is 50-100 mg per week for women and 100-200 mg per week for men. For children aged 2-13, the average dose is 25-50 mg every 3-4 weeks.
• Common side effects include swelling, fluid retention, breast enlargement, insomnia, nausea, and acne.
• It is not recommended for use in children under 3 years old, pregnant/breastfeeding women, or patients with allergies to nandrolone, peanuts, or soy.
• Nandrolone decanoate has an elimination half-life of approximately 6-12 days when administered by intramuscular injection. The active nandrolone has a blood half-life of 4.3 hours.
• Nandrolone decanoate can also be effectively administered by subcutaneous injection, which may be more convenient and less painful than intramuscular.
  

  Pharmacokinetics and Dosage

  • Nandrolone decanoate is slowly absorbed from the intramuscular injection site, with a peak serum concentration around 30 hours after injection.
  • The elimination half-life is approximately 6-12 days after intramuscular administration.
  • Recommended dosages:
    • Anemia of renal disease: 50-100 mg/week for women, 100-200 mg/week for men. For children 2-13 years old, 25-50 mg every 3-4 weeks.
    • Osteoporosis: 50 mg every 2-4 weeks.
  • Nandrolone decanoate can also be effectively administered by subcutaneous injection, which may be more convenient and less painful.

  Formulations and Packaging

  • Available in 100 mg/mL and 200 mg/mL intramuscular injection formulations.
  • Packaged in multi-dose vials of 2 mL (100 mg/mL) and single-dose vials of 1 mL (200 mg/mL).

  Regulatory Status

  • Nandrolone decanoate was first approved by the FDA in 1962.
  • It is classified as a Schedule III controlled substance in the United States.

  Pharmacoeconomics

  • Pricing information is limited, but a 100 mg/mL vial is reported to cost around $97 USD.
  • No specific patent or manufacturer details are provided in the search results.
  

  Nandrolone decanoate

  Androgen and anabolic steroid medication

  More

  Uses

  Used primarily in the treatment of anemias and wasting syndromes, as well as osteoporosis in menopausal women.

  Administration

  Given by injection into muscle or fat once every one to four weeks.

  Side effects

  May include symptoms of masculinization like acne, increased hair growth, and voice changes.
  Nandrolone decanoate is an anabolic-androgenic steroid that exerts its effects primarily through the following mechanisms:

  Androgen Receptor Agonism

  • Nandrolone decanoate is a prodrug that is hydrolyzed to nandrolone, which then enters cells and binds to the androgen receptor (AR).
  • Binding to the AR causes a conformational change, allowing the receptor to dimerize and translocate to the nucleus.
  • In the nucleus, the AR dimer binds to androgen response elements on DNA to regulate the transcription of target genes involved in anabolic and androgenic effects.

  Reduced 5α-Reductase Metabolism

  • Unlike testosterone, nandrolone is not potentiated by 5α-reductase into a more potent AR agonist like dihydrotestosterone in certain tissues.
  • Instead, nandrolone is inactivated by 5α-reductase in tissues like the skin, hair follicles, prostate, and brain.
  • This results in a lower incidence of androgenic side effects like acne, hirsutism, scalp hair loss, and prostate issues compared to testosterone.

  Progestogenic Activity

  • Nandrolone decanoate has moderate progestogenic activity via its metabolite 5α-dihydronandrolone.
  • The progestogenic activity may contribute to the antigonadotropic effects and suppression of testosterone levels.

  key benefits and ingredients of various skincare products:

  Shea Butter

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  • Excellent moisturizer

  Coconut Oil

  • Softens and moisturizes skin
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  Black Soap

  • Gentle, all-natural cleanser
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  Coffee

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  Himalayan Pink Salt

  • Helps draw out toxins and deep cleanse the skin
  • Cleanses the body energetically

  Mint

  • Contains antioxidant vitamins A and C to fight inflammation
  • Contains B vitamins to help brighten skin
  • Can ease swelling, reduce redness, and calm itchiness

  Vitamin E

  • Essential for healthy skin growth and repair
  • Prevents premature aging and wrinkling

  Glycerin

  • Highly water-absorbing ingredient that attracts moisture to hydrate skin

  Lavender Oil

  • Has anti-inflammatory and antifungal properties to help treat acne, eczema, and psoriasis

  Rosemary Oil

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  • Balances skin’s natural oils

  Retinol

  • Enhances skin cell production for a stronger skin barrier
  • Improves skin elasticity and collagen production
  • Helps unclog pores and clear acne

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  • Boosts collagen production to prevent fine lines and wrinkles
  • Has anti-inflammatory properties to reduce irritation, dark spots, and redness
  • Reduces melanin production to even out skin tone

  Hyaluronic Acid

  • Binds water in the skin to lock in moisture
  • Helps maintain skin’s plumpness and volume

  Dosage and Administration

  • Nandrolone Decanoate Injection:
    • Anemia of Renal Disease: 50-100 mg per week for women and 100-200 mg per week for men. For children aged 2-13 years, 25-50 mg every 3-4 weeks.
    • Osteoporosis: 50 mg once every 2-4 weeks by intramuscular injection.
    • Breast Cancer: 50 mg once every 2-4 weeks by intramuscular injection.

  Storage and Handling

  • Storage: Store at 20°-25°C (68°-77°F) [See USP Controlled Room Temperature]. Protect from light. Store in carton until contents are used.
  • Handling: Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever the solution and container permit.

  Reviews and Ratings

  • Empower Pharmacy: Offers Nandrolone Decanoate Injection in 200 mg/mL strength, available through both 503A Compounding Pharmacy and 503B Outsourcing Facility.
  • IndiaMART: Provides Nandrolone Decanoate Injection in 100 mg strength, used to treat osteoporosis in post-menopausal women, certain types of anemia, and breast cancer.