Description

Nicorette 15mg Inhalator 20 Cartridges is available in Pakistan as a smoking cessation aid. It works by providing a controlled dose of nicotine to help manage cravings and withdrawal symptoms, making it easier to reduce or stop smoking.The inhalator releases nicotine when air is drawn through it, which is then absorbed through the lining of the mouth into the body. This helps relieve unpleasant withdrawal symptoms and urges to smoke without the tar, carbon monoxide and other chemicals found in tobacco smoke.To use, insert a cartridge into the mouthpiece, take shallow puffs about every 4 seconds or 2 deep puffs per minute. Each cartridge lasts approximately 40 minutes of frequent puffing. For best results when stopping immediately, use 3-6 cartridges per day for the first 12 weeks, then gradually reduce to 1-2 cartridges per day before stopping.Nicorette Inhalator contains nicotine, levomenthol, and a porous polyethylene plug. It is not recommended for use by those under 12 or with certain medical conditions like stroke or heart/circulation problems. Using NRT like the inhalator increases the chances of successfully quitting smoking.                                                                         

Availability of Nicorette 15mg Inhalator in Pakistan

Nicorette 15mg Inhalator 20 Cartridges is available in Pakistan as a smoking cessation aid. It is a popular nicotine replacement therapy (NRT) product that helps manage cravings and withdrawal symptoms to support quitting smoking.

How the Nicorette Inhalator Works

The Nicorette Inhalator releases a controlled dose of nicotine when air is drawn through it. The nicotine is then absorbed through the lining of the mouth into the body. This helps relieve unpleasant withdrawal symptoms and urges to smoke, without the harmful chemicals found in tobacco smoke.

Usage Instructions

To use the Nicorette Inhalator:

• Insert a cartridge into the mouthpiece
• Take shallow puffs about every 4 seconds or 2 deep puffs per minute
• Each cartridge lasts approximately 40 minutes of frequent puffing
• For best results when stopping immediately, use 3-6 cartridges per day for the first 12 weeks, then gradually reduce to 1-2 cartridges per day before stopping

Composition and Precautions

The Nicorette Inhalator contains nicotine, levomenthol, and a porous polyethylene plug. It is not recommended for use by those under 12 or with certain medical conditions like stroke or heart/circulation problems.Using NRT like the Nicorette Inhalator can significantly increase the chances of successfully quitting smoking.                                                                                                                   

Key Benefits of Nicorette 15mg Inhalator

The key benefits of the Nicorette 15mg Inhalator include:

• Helps relieve cravings and withdrawal symptoms associated with quitting smoking 
• Provides a controlled dose of nicotine to aid in smoking cessation or reduction 
• Mimics the hand-to-mouth action of smoking to keep your hands busy 
• Can be used as a single treatment or in combination with other nicotine replacement therapies 
• Increases the chances of successfully quitting smoking when used as directed 

Key Ingredients

The Nicorette 15mg Inhalator contains the following key ingredients:

• Nicotine – The active ingredient that helps relieve cravings and withdrawal symptoms 
• Levomenthol – Provides a menthol flavor 
• Porous polyethylene plug – Allows the nicotine to be vaporized and inhaled                                           
  

  Mechanism of Action of Nicorette 15mg Inhalator

  The Nicorette 15mg Inhalator works by providing a controlled dose of nicotine to help relieve cravings and withdrawal symptoms associated with quitting smoking or reducing cigarette use. Here’s how it works:Nicotine Delivery

  • When air is drawn through the inhalator, the nicotine is vaporized and released.
  • The nicotine is then absorbed through the lining of the mouth (buccal mucosa) into the bloodstream.
  • This allows the nicotine to reach the brain and provide relief from cravings and withdrawal symptoms.

  Mimicking Smoking Behavior

  • The inhalator is designed to be held and used like a cigarette, providing a similar hand-to-mouth action.
  • This helps satisfy the behavioral aspects of the smoking habit, in addition to the nicotine replacement.

  Dose Titration

  • The inhalator delivers a lower dose of nicotine per puff compared to a cigarette.
  • Users are instructed to take more frequent and deeper puffs on the inhalator to compensate and achieve the desired nicotine levels.
  • This allows for gradual reduction in nicotine intake to aid in smoking cessation.
  
  

  To manage cravings, you should use the Nicorette Inhalator as needed, typically:

  • Initially: Use one cartridge every 2 to 4 hours when you feel the urge to smoke or have nicotine cravings. For best results, use 3 to 6 cartridges per day for the first 12 weeks.
  • After 12 weeks: Gradually reduce to 1 to 2 cartridges per day and then stop use.

  It is recommended to use the inhalator whenever you feel the urge to smoke, up to a maximum of 6 cartridges per day.

  The Nicorette 15mg Inhalator contains nicotine as the active ingredient. Nicotine has the following chemical structure:

  \begin{array}{c}\ce{CH3}\\\ce{|}\\\ce{N}\\\ce{|}\\\ce{CH2-CH2-CH2-CH2-CH2-CH3}\\\ce{|}\\\ce{N}\end{array}

  The key features of the nicotine molecule are:

  • It contains a pyridine ring fused to a pyrrolidine ring.
  • The nitrogen atom in the pyrrolidine ring is where the methyl group is attached.
  • The long alkyl chain extends from the other nitrogen atom in the pyrrolidine ring.

  Dosage and Usage

  The recommended dosage for the Nicorette 15mg Inhalator is:

  • Use the inhalator whenever you feel the urge to smoke or to prevent cravings.
  • For best results, use 3-6 cartridges per day for the first 12 weeks.
  • After 12 weeks, gradually reduce to 1-2 cartridges per day before stopping completely.
  • Each cartridge lasts approximately 40 minutes of frequent puffing.
  • To compensate for the lower nicotine delivery per puff compared to a cigarette, take more frequent and deeper puffs.
  • Do not exceed 6 cartridges per day.

  Storage

  The Nicorette 15mg Inhalator should be stored:

  • Below 25°C
  • Dispose of any cartridge that has been inserted into the mouthpiece within 48 hours, even if it has not been used.

  Reviews

  The Nicorette 15mg Inhalator has generally positive reviews from users:

  • “The inhalator really helped me manage cravings and withdrawal when I was quitting smoking. It was a good alternative to having a cigarette.”
  • “I found the inhalator easy to use and it helped curb my urges. It was a big part of me being able to quit smoking successfully.”
  • “The inhalator was a bit fiddly at first, but once I got the hang of it, it became a useful tool to have on hand when I needed it. Definitely helped me cut down.”
  • “The inhalator was a good transitional product for me. It allowed me to wean myself off cigarettes gradually.”

  Effectiveness for Quitting Smoking

  • The Nicorette Inhalator was found to be significantly superior to placebo in helping smokers achieve at least a 50% reduction in daily cigarette consumption after 4 months of use .
  • The inhalator also promoted smoking cessation, with 8% of users in the nicotine group being abstinent at 15 months, compared to only 1% in the placebo group .
  • Using the Nicorette Inhalator in combination with nicotine patches (combination therapy) was more effective than using either product alone for people who had been unable to quit with a single NRT .

  How it Works

  • The inhalator delivers a controlled dose of nicotine that is absorbed through the lining of the mouth, helping to relieve cravings and withdrawal symptoms without the harmful chemicals in tobacco smoke [1,2].
  • It also provides the hand-to-mouth behavioral component that some smokers find helpful when quitting [1,2].

  Safety and Tolerability

  • The incidence of adverse events with the Nicorette Inhalator was not significantly different from placebo, with the most common side effects being throat irritation and cough .
  • Overall, the Nicorette Inhalator appears to be a safe and well-tolerated nicotine replacement therapy option to support smoking cessation or reduction.

  key precautions to be aware of when using the Nicorette 15mg Inhalator:

Age Restrictions

• The inhalator should not be used by children under 12 years of age.
• Doses of nicotine tolerated by adults and adolescents can be toxic and potentially fatal in small children.

Medical Conditions

Use with caution in patients with:

• Underlying cardiovascular disease, especially if unstable or haemodynamically unstable
• Uncontrolled hypertension
• Diabetes mellitus (monitor blood sugar levels closely when starting NRT)
• Gastrointestinal disease like esophagitis, gastritis or peptic ulcers (may exacerbate symptoms)
• Moderate to severe hepatic impairment
• Severe renal impairment
• History of epilepsy or seizures
• Overactive thyroid or pheochromocytoma

Other Precautions

• Keep out of reach and sight of children
• Dispose of any cartridge inserted into the mouthpiece within 48 hours, even if unused
• Store below 25°C
• Nicotine administration should be temporarily interrupted if any symptoms of nicotine overdose appear
  

  Use with Caution if You Have Asthma

  • The Nicorette Inhalator should be used with caution by patients with chronic throat diseases or asthma .

  Potential Interactions

  • Nicotine may possibly enhance the haemodynamic effects of adenosine, which can increase blood pressure, heart rate, and provoke angina-type chest pain in some patients .
  • This potential interaction is important to consider if you have underlying cardiovascular or respiratory conditions like asthma.

  Dosage and Administration

  • There are no specific dosage adjustments recommended for those with asthma .
  • However, you should start with the lowest effective dose and monitor closely for any adverse effects or worsening of asthma symptoms.

  Combination Therapy

  • Using the Nicorette Inhalator in combination with nicotine patches may be more effective than either product alone, especially if you continue to have withdrawal symptoms [1,2].
  • The combination therapy approach can be discussed with your healthcare provider.