Description

Tolvat 15mg Tablet is a medication used to treat low sodium levels in the blood, which can occur in conditions like heart disease or liver disease. The key points about Tolvat 15mg Tablet are:

• It contains the active ingredient Tolvaptan, which is a vasopressin antagonist that blocks the action of the antidiuretic hormone vasopressin on the kidneys. This leads to increased urine production and decreased water content in the blood, thereby raising sodium levels.
• Tolvat 15mg Tablet is not recommended for use in pregnant or breastfeeding women, those with severe dehydration, improper kidney function, or liver disease. It should be used with caution in the elderly and those with congestive heart failure.
• Common side effects include headache, dizziness, excessive thirst, dry mouth, and increased urination. Patients should avoid driving or operating machinery if they experience dizziness or drowsiness.
• Tolvat 15mg Tablet does not cause significant changes in heart rate or blood pressure. However, patients should consult their doctor if they experience any high blood pressure symptoms.
• The recommended dosage is as directed by the physician. Overdose can lead to symptoms like increased urination, thirst, and dehydration.
  

  Unique Features

  • Contains the active ingredient Tolvaptan, a vasopressin antagonist that increases urine production and raises sodium levels
  • Not recommended for use in pregnant/breastfeeding women, those with severe dehydration, kidney or liver disease
  • Should be used with caution in the elderly and those with congestive heart failure

  Dosage and Administration

  • Dosage as directed by physician
  • Overdose can lead to increased urination, thirst, and dehydration

  Side Effects

  • Common side effects include headache, dizziness, excessive thirst, dry mouth, and increased urination
  • Patients should avoid driving or operating machinery if they experience dizziness or drowsiness

  Precautions

  • Does not cause significant changes in heart rate or blood pressure, but patients should monitor for high blood pressure symptoms
  • Requires careful monitoring due to potential side effects and contraindications

  Key Benefits of Tolvat 15mg Tablet

  • Treats low sodium levels in the blood (hyponatremia) caused by conditions like heart disease, liver disease, or hormonal imbalances
  • Also used to treat autosomal dominant polycystic kidney disease (ADPKD)
  • Blocks the action of vasopressin hormone, leading to increased urine production and raised sodium concentration in the blood

  Key Ingredient

  • The active ingredient in Tolvat 15mg Tablet is Tolvaptan, which belongs to the class of vasopressin V2 receptor antagonists

    Tolvat 15mg Tablet works by blocking the action of vasopressin (also known as antidiuretic hormone) on the kidneys. This results in:

    1. Increased Urine Production: Vasopressin normally helps the kidneys retain water by reducing urine output. By blocking vasopressin, Tolvat 15mg Tablet increases urine production, leading to a decrease in water content in the blood.
    2. Raised Sodium Concentration: The increased urine production and decreased water content in the blood result in an increase in serum sodium concentrations, effectively treating low sodium levels (hyponatremia).

    Key Mechanism of Action

    • Vasopressin Antagonism: Tolvat 15mg Tablet blocks the action of vasopressin on the kidneys, leading to increased urine production and a decrease in water content in the blood.
    • Increased Free Water Excretion: The antagonist effect of Tolvat 15mg Tablet results in an increase in free water excretion, which is not associated with increased excretion of sodium or potassium ions.
    • Increased Serum Sodium Concentrations: The net effect is an increase in serum sodium concentrations, effectively treating hyponatremia.

    Summary

    Tolvat 15mg Tablet is a vasopressin antagonist that increases urine production and decreases water content in the blood, thereby raising serum sodium concentrations. This mechanism helps treat low sodium levels in conditions such as heart failure, liver disease, and hormonal imbalances like SIADH.
    

    Watch

    

  Chemical Structure of Tolvaptan (Active Ingredient)

  The active ingredient in Tolvat 15mg Tablet is Tolvaptan, which has the following chemical structure:

  \begin{array}{c}\ce{C_{26}H_{25}N_{3}O_{3}}\\\text{Molecular Weight 448 95 g mol}\end{array}

  Tolvaptan is a benzazepine derivative and a selective vasopressin V2-receptor antagonist. The chemical structure shows it is a complex organic molecule with multiple aromatic rings and functional groups.The search results indicate that Tolvat 15mg Tablet contains 15mg of the active ingredient Tolvaptan, along with the following inactive ingredients:

  • Anhydrous lactose
  • Silicon dioxide
  • Copovidone K25-31
  • Croscarmellose sodium
  • Magnesium stearate
  • FD&C Blue No. 2

  Tolvaptan’s Ring Structure

  Tolvaptan, the active ingredient in Tolvat 15mg Tablet, has a complex chemical structure containing multiple aromatic rings. The key features of its ring structure are:

  • Benzazepine Ring: Tolvaptan is a benzazepine derivative, meaning it contains a fused benzene ring and seven-membered azepine ring. This is the core structure of the molecule.
  • Chlorobenzene Ring: Attached to the benzazepine ring is a chlorobenzene ring (a benzene ring with a chloro substituent).
  • Pyridine Ring: Another aromatic ring present is a pyridine ring (a six-membered heterocyclic ring with one nitrogen atom).
  • Phenyl Ring: The structure also contains a phenyl ring (a simple benzene ring).

  The presence of multiple aromatic ring systems contributes to the overall complexity and rigidity of the tolvaptan molecule. The chloro and methyl substituents on the rings also influence its physicochemical properties and biological activity as a selective vasopressin V2-receptor antagonist.In summary, the key structural feature of tolvaptan is its benzazepine core, which is decorated with chlorobenzene, pyridine, and phenyl rings, giving rise to its unique chemical structure and pharmacological profile.
  

  

  

  

  Recommended Dosage

  • The typical dosage of Tolvat 15mg Tablet is once daily.
  • The dosage should be taken as directed by the physician and should not be exceeded without consulting the doctor.
  • The tablet should be swallowed whole with a glass of water. It should not be crushed, broken or chewed.

  Missed Dose

  • If a dose is missed, it should be taken as soon as possible.
  • Do not take a double dose to make up for a missed one.

  Overdose

  • Symptoms of overdose include increased frequency of urination, excessive thirst, and dehydration.
  • If an overdose occurs, immediately contact the doctor or the nearest hospital.

  Storage and Disposal of Tolvat 15mg Tablet

  • Store the tablets at room temperature, below 30°C, in the original package.
  • Keep the medicine away from heat, moisture, and direct light.
  • Store it out of the reach of children and pets.
  • Dispose of any unused or expired medication properly, as per the instructions of the healthcare provider or pharmacist.

  User Reviews of Tolvat 15mg Tablet

  Based on the available search results, there are limited user reviews for Tolvat 15mg Tablet specifically. However, some general points about user experiences with tolvaptan (the active ingredient) can be summarized:

  • Patients report that tolvaptan is effective in raising serum sodium levels in conditions like heart failure, liver disease, and SIADH.
  • Common side effects noted include increased urination, thirst, dizziness, and headaches, which are generally manageable.
  • Some users mention the need for close monitoring of fluid intake and electrolyte levels while on tolvaptan.
  • Overall, tolvaptan appears to be well-tolerated by most patients when used as directed and under medical supervision.

  Duration of Use

  • Tolvat 15mg Tablet is typically used to treat low sodium levels (hyponatremia) associated with conditions like heart failure, liver disease, and SIADH.
  • The duration of treatment with Tolvat 15mg Tablet is usually not more than 30 days.
  • Once the sodium levels return to normal, the medication can be stopped after consulting the doctor.
  • Prolonged use beyond 30 days is generally not recommended, as it may increase the risk of side effects.

  Continuous vs. Intermittent Use

  • The search results do not mention the option of using Tolvat 15mg Tablet intermittently or with breaks.
  • The general recommendation is to take the medication continuously as prescribed by the doctor, without breaks, until the sodium levels are normalized.
  • Stopping the medication abruptly without consulting the doctor is not advised, as it may lead to a rapid decrease in sodium levels again.