Description

Sandimmun Neoral 25mg 50’ct Capsules is a medication used to prevent organ rejection in people who have received a liver, kidney, or heart transplant. It is also used to treat severe cases of rheumatoid arthritis and plaque psoriasis.The key points are:

• Sandimmun Neoral is the brand name for the drug cyclosporine, which is an immunosuppressant medication.
• It is available in 25mg and 100mg capsule strengths.
• The 25mg capsules are blue-gray in color, oval-shaped, and imprinted with “NEORAL 25mg”.
• The recommended initial oral dose of Sandimmun Neoral varies depending on the transplanted organ, but is typically 7-9 mg/kg/day divided into two equal doses.
• The dose is then adjusted based on monitoring of cyclosporine blood levels to achieve the target therapeutic range.
• Sandimmun Neoral has improved bioavailability compared to the previous formulation, Sandimmune, resulting in higher peak blood concentrations.
• Common side effects include kidney problems, high blood pressure, tremors, and increased risk of infection.
  

  Medication Overview

  Sandimmun Neoral is a brand name for the immunosuppressant drug cyclosporine. It is used to prevent organ rejection in people who have received a liver, kidney, or heart transplant. Sandimmun Neoral is also used to treat severe cases of rheumatoid arthritis and plaque psoriasis.

  Capsule Characteristics

  The Sandimmun Neoral 25mg capsules are blue-gray in color, oval-shaped, and imprinted with “NEORAL 25mg”. They are available in a 50-count bottle.

  Dosage and Administration

  The recommended initial oral dose of Sandimmun Neoral varies depending on the transplanted organ, but is typically 7-9 mg/kg/day divided into two equal doses. The dose is then adjusted based on monitoring of cyclosporine blood levels to achieve the target therapeutic range.

  Improved Bioavailability

  Sandimmun Neoral has improved bioavailability compared to the previous formulation, Sandimmune, resulting in higher peak blood concentrations.

  Side Effects

  Common side effects of Sandimmun Neoral include kidney problems, high blood pressure, tremors, and increased risk of infection.

  Key Benefits of Sandimmun Neoral 25mg Capsules

  Based on the search results, the key benefits of Sandimmun Neoral 25mg Capsules include:Organ Transplant Rejection Prevention
  Sandimmun Neoral is an immunosuppressant medication used to prevent the body from rejecting a transplanted organ, such as a liver, kidney, or heart.Treatment of Autoimmune Conditions
  In addition to transplant rejection, Sandimmun Neoral is also used to treat severe cases of rheumatoid arthritis and plaque psoriasis by reducing inflammation and immune system activity.Improved Bioavailability
  Compared to the previous formulation Sandimmune, Sandimmun Neoral has improved bioavailability, resulting in higher peak blood concentrations of the active ingredient cyclosporine.

  Key Ingredients

  The key ingredient in Sandimmun Neoral 25mg Capsules is:

  • Cyclosporine – An immunosuppressant drug that works by suppressing the body’s immune system to prevent organ rejection or reduce inflammation in autoimmune conditions.

  The capsules also contain the following excipients:

  • Gelatin
  • Medium-chain triglycerides
  • Polyoxyl 40 hydrogenated castor oil
  • Ethanol
  • Propylene glycol
  • Corn oil-mono-di-triglycerides
  • Butylhydroxytoluene
    

    Mechanism of Action of Sandimmun Neoral

    Based on the search results, the key points about the mechanism of action of Sandimmun Neoral (cyclosporine) are:Immunosuppression
    Cyclosporine is a calcineurin inhibitor that suppresses cellular and humoral immunity, primarily by inhibiting T-cell activation and proliferation.Inhibition of Lymphokine Production
    At the cellular level, cyclosporine inhibits the production and release of lymphokines, including interleukin-2 (T-cell growth factor).Cell Cycle Arrest
    Cyclosporine appears to block resting lymphocytes in the G0 or G1 phase of the cell cycle, and inhibits the antigen-triggered release of lymphokines by activated T-cells.Specific and Reversible Action on Lymphocytes
    Unlike cytostatic agents, cyclosporine acts specifically and reversibly on lymphocytes, without depressing hematopoiesis.

    
    
    

    Ciclosporin

    Immunosuppressant medication

    More

    Uses

    Used for rheumatoid arthritis, psoriasis, Crohn’s disease, nephrotic syndrome, eczema, organ transplants to prevent rejection, and as eye drops for dry eyes.

    Administration

    Can be administered orally, intravenously, or as eye drops.

    Drug Class

    Calcineurin inhibitor

    Chemical Structure of Cyclosporine

    According to the search results, the key points about the chemical structure of cyclosporine, the active ingredient in Sandimmun Neoral, are:Molecular Formula and Mass
    The molecular formula of cyclosporine is C62H111N11O12, with a molecular mass of 1202.64 g/mol.Structural Formula
    Cyclosporine has a cyclic structure composed of 11 amino acids. The structural formula is described as:
    (R-[R*,R*-(E)]]-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-α-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl).Also Known As
    Cyclosporine is also known as cyclosporin A and ciclosporin.

    

    

    

    Dosage

    • The recommended initial oral dose of Sandimmun Neoral varies depending on the transplanted organ, but is typically 7-9 mg/kg/day divided into two equal doses.
    • The dose is then adjusted based on monitoring of cyclosporine blood levels to achieve the target therapeutic range.
    • For rheumatoid arthritis and psoriasis, the recommended starting dose is 1.25 mg/kg taken orally twice daily.
    • Doses may be increased gradually up to a maximum of 4 mg/kg/day if needed.

    Storage

    • Sandimmun Neoral capsules should be stored at room temperature, away from direct sunlight.
    • The oral solution formulation should be stored between 15-30°C and not refrigerated or frozen.

    Reviews

    The search results did not provide any specific reviews or feedback on Sandimmun Neoral 25mg capsules. As a prescription medication, patient experiences and reviews would not be readily available in these types of search results. The information focused more on the dosing, administration, and storage guidelines for this cyclosporine formulation.