Description

Actilyse, with the active ingredient alteplase, is indeed a thrombolytic agent used to dissolve blood clots that form in blood vessels. This medication is often used in various medical conditions where the presence of blood clots can be life-threatening. Here’s some detailed information on Actilyse and its uses:

1. Heart Attack (Myocardial Infarction): Actilyse is used to treat heart attacks caused by blood clots in the arteries of the heart, which is medically known as myocardial infarction. When a blood clot obstructs the blood flow to the heart muscle, it can lead to damage or death of heart tissue. Alteplase works by breaking down the clot and restoring blood flow to the affected area of the heart, minimizing damage.
2. Pulmonary Embolism: A pulmonary embolism occurs when a blood clot travels to the lungs, blocking one of the pulmonary arteries. This condition can be life-threatening, as it can reduce the supply of oxygen to the body. Actilyse is used to dissolve these clots in the pulmonary artery, restoring blood flow to the lungs.
3. Acute Ischemic Stroke: Actilyse is also employed to treat acute ischemic strokes. These strokes occur when a blood clot forms in an artery of the brain, cutting off blood supply to a specific area of the brain. Alteplase helps to break down the clot and restore blood flow to the brain, potentially minimizing or preventing damage caused by the stroke. It’s crucial to administer this treatment promptly in the case of stroke, as the effectiveness of alteplase diminishes over time.
   

   Key Benefits

   1. Treats heart attacks: Actilyse helps dissolve blood clots in the heart’s arteries, restoring blood flow and minimizing damage.
   2. Treats strokes: By breaking down clots in the brain’s arteries, Actilyse can reduce the risk of long-term disability from stroke.
   3. Treats pulmonary embolism: Actilyse can help dissolve blood clots in the lungs, improving blood flow and oxygen delivery.

   Availability and Cost

   • Actilyse 50mg Injection is available in Pakistan with a prescription.
   • The cost is around Rs. 35,018 per 50mg vial.

   Important Considerations

   • Actilyse can have serious side effects like bleeding, so it requires close medical supervision.
   • Patients should be aware of the risks and benefits before using this medication.

   Key Ingredient

   The main active ingredient is alteplase, which is a clot-dissolving drug.

   Other Ingredients

   Actilyse 50mg Injection also contains:

   • Arginine
   • Phosphoric acid
   • Polysorbate 80
   • Sucrose

   Dosage

   • The dose is based on body weight, up to a maximum of 90-100 mg
   • 10% is given as an initial IV bolus
   • The remaining 90% is infused IV over 60 minutes

   Storage

   • Store the powder below 25°C and protect from light
   • After mixing, the solution can be kept for up to 24 hours at 2-8°C
   • Use the mixed solution as soon as possible

   Safety

   • Actilyse 50mg Injection can have serious side effects, particularly increased risk of bleeding.
   • Patients should inform their doctor of any medical conditions or other medications they are taking before receiving this treatment.