Forxiga 10mg tablet 28’ct
Forxiga 10mg Tablet is an oral antidiabetic medication used to treat type 2 diabetes in adults. The key points about Forxiga 10mg Tablet are:
- It contains the active ingredient dapagliflozin, which is a sodium-glucose cotransporter-2 (SGLT-2) inhibitor. This helps remove excess glucose from the body through urine, thereby lowering blood sugar levels.
- The recommended dose is 10mg once daily, which can be taken with or without food. The dose may be adjusted when used in combination with insulin or insulin secretagogues to reduce the risk of hypoglycemia.
- Forxiga 10mg Tablet is indicated for the treatment of type 2 diabetes, either as monotherapy when metformin is inappropriate, or in addition to other diabetes medications.
- It has also been shown to be effective in reducing the risk of cardiovascular and renal events in certain patient populations.
- Common side effects include fungal infections, urinary tract infections, and increased urination. Dehydration can also occur, so maintaining fluid intake is important.
- Forxiga 10mg Tablet should be used cautiously in patients with kidney disease, and is not recommended for those with severe kidney impairment (eGFR < 15 mL/min/1.73m2).
Mechanism of Action
Forxiga is the first-in-class SGLT-2 inhibitor approved for the treatment of type 2 diabetes. It works by selectively inhibiting the sodium-glucose cotransporter-2 in the renal proximal convoluted tubules, reducing reabsorption of filtered glucose from the tubular lumen and lowering the renal threshold for glucose.
Description
Forxiga 10mg Tablet is an oral antidiabetic medication used to treat type 2 diabetes in adults. The key points about Forxiga 10mg Tablet are:
- It contains the active ingredient dapagliflozin, which is a sodium-glucose cotransporter-2 (SGLT-2) inhibitor. This helps remove excess glucose from the body through urine, thereby lowering blood sugar levels.
- The recommended dose is 10mg once daily, which can be taken with or without food. The dose may be adjusted when used in combination with insulin or insulin secretagogues to reduce the risk of hypoglycemia.
- Forxiga 10mg Tablet is indicated for the treatment of type 2 diabetes, either as monotherapy when metformin is inappropriate, or in addition to other diabetes medications.
- It has also been shown to be effective in reducing the risk of cardiovascular and renal events in certain patient populations.
- Common side effects include fungal infections, urinary tract infections, and increased urination. Dehydration can also occur, so maintaining fluid intake is important.
- Forxiga 10mg Tablet should be used cautiously in patients with kidney disease, and is not recommended for those with severe kidney impairment (eGFR < 15 mL/min/1.73m2).
Mechanism of Action
Forxiga is the first-in-class SGLT-2 inhibitor approved for the treatment of type 2 diabetes. It works by selectively inhibiting the sodium-glucose cotransporter-2 in the renal proximal convoluted tubules, reducing reabsorption of filtered glucose from the tubular lumen and lowering the renal threshold for glucose.
Cardiovascular and Renal Benefits
In clinical trials, Forxiga has demonstrated cardiovascular and renal benefits beyond just glucose lowering:
- The DECLARE-TIMI 58 trial showed Forxiga reduced the risk of cardiovascular death or hospitalization for heart failure by 17% in patients with type 2 diabetes.
- The DAPA-CKD trial found Forxiga reduced the risk of worsening of renal function, end-stage kidney disease, or cardiovascular death by 39% in patients with chronic kidney disease.
Weight Loss Effect
Treatment with Forxiga has been associated with modest weight loss, with a mean reduction of 2-3 kg compared to placebo. This is thought to be due to the caloric loss from increased urinary glucose excretion.
Flexible Dosing
Forxiga can be taken at any time of day, with or without food. This allows for flexible dosing to suit the patient’s preference and lifestyle.
Contraindications and Precautions
Forxiga is contraindicated in patients with a history of serious hypersensitivity reaction to the drug. It should be used with caution in patients at risk for volume depletion, such as the elderly, those with renal impairment, or taking diuretics.
Key Benefits:
- Lowers high blood sugar levels in adults with type 2 diabetes
- Reduces the risk of cardiovascular and renal events in patients with type 2 diabetes and established cardiovascular disease
- Can lead to modest weight loss due to increased urinary glucose excretion
- Flexible dosing – can be taken with or without food, at any time of day
Key Ingredient:
- The active ingredient in Forxiga 10mg Tablet is dapagliflozin
- Dapagliflozin is a sodium-glucose cotransporter-2 (SGLT-2) inhibitor, which works by reducing the reabsorption of filtered glucose in the renal proximal convoluted tubules
- This leads to increased urinary glucose excretion and lowering of blood glucose levels in patients with type 2 diabetes
Dosage
- Take one 10mg tablet once daily
- May start at 5mg if you have liver problems
- Take at the same time each day, with or without food
- Do not stop taking without consulting your doctor
Storage
- Store at room temperature
- Keep out of sight and reach of children
- Do not use after expiry date
- Dispose of properly when expired or unused
Reviews
- Effectively lowers blood sugar in type 2 diabetes
- Reduces cardiovascular and kidney disease risk
- Modest weight loss of 2-3 kg on average
- Generally well-tolerated, with common side effects
- Positive user experiences when taken as directed
Reviews
There are no reviews yet.