Description

Humalog Mix 50 is a combination of fast-acting insulin lispro and long-acting insulin lispro protamine. It is used to control high blood sugar levels in people with diabetes. Some key points about Humalog Mix 50 Insulin Pen 5’ct Imported from Turkey:

• Humalog Mix 50 is a white suspension that must be administered by subcutaneous injection only, not intravenously.
• It has a rapid onset of action and shorter duration compared to regular insulin, so it should be taken within 15 minutes before a meal.
• Any changes to a patient’s insulin regimen should be made cautiously and under medical supervision, as differences in purity, strength, brand, type, species, or manufacturing method may require dosage adjustments.
• Potential side effects include hypoglycemia, diabetic acidosis and coma, lipodystrophy at injection sites, and allergic reactions.
• Humalog Mix 50 requires a prescription and is used for diabetes management.
  

  Dual-Action Insulin

  Humalog Mix 50 contains a 50/50 blend of fast-acting insulin lispro and long-acting insulin lispro protamine. This provides both rapid control of blood sugar after meals and extended basal insulin coverage.

  Convenient Pen Delivery

  The Humalog Mix 50 is available in a pre-filled, disposable pen device. This makes it easy for patients to accurately dose and administer the insulin without the need for vials and syringes.

  Imported from Turkey

  This particular Humalog Mix 50 product is imported from Turkey, which may have some differences compared to versions available in other countries. The manufacturing origin could impact factors like pricing, availability, or regulatory approvals.

  5-Count Package

  The product comes in a package of 5 insulin pens, which provides a convenient multi-use supply for patients. The 5-count packaging may not be available for all Humalog Mix 50 products.

  Potential Cost Savings

  Importing the insulin from Turkey could potentially offer cost savings compared to purchasing the product domestically, though the exact price difference would depend on various factors.  Humalog Mix 50 is a combination of fast-acting insulin lispro and long-acting insulin lispro protamine suspension. Its mechanism of action can be summarized as follows:

  Rapid Onset of Action

  The insulin lispro component in Humalog Mix 50 has a rapid onset of glucose-lowering activity, an earlier peak, and a shorter duration compared to regular human insulin. This allows Humalog Mix 50 to be administered very close to mealtime, within 15 minutes before a meal.

  Prolonged Duration

  The insulin lispro protamine suspension component of Humalog Mix 50 has a duration of action similar to a basal insulin like NPH. This provides extended basal insulin coverage.

  Dual-Action Profile

  By combining the rapid onset of insulin lispro with the intermediate action of insulin lispro protamine suspension, Humalog Mix 50 exhibits a distinct biphasic insulin activity profile. This dual-action helps control both postprandial and basal blood glucose levels.

  Affected by Various Factors

  The time course of action of Humalog Mix 50 can vary considerably in different individuals or within the same individual. Factors like dose, site of injection, blood supply, temperature, and physical activity can affect the onset, peak, and duration of activity.

  

  Insulin lispro

  Modified type of medical insulin used to treat diabetes

  More

  Trade names

  Humalog, Liprolog, Admelog, others

  Onset of effects

  Within 30 minutes

  Duration of effects

  Lasts about 5 hours

  The search results do not provide any information about the ring structure of insulin lispro, the active ingredient in Humalog Mix 50. The results focus more on the pharmacodynamics, pharmacokinetics, and clinical use of Humalog Mix 50.However, we can infer some details about the ring structure of insulin lispro from its chemical structure:

  • Insulin lispro has the empirical formula C257H383N65O77S6 and a molecular weight of 5808, both identical to that of human insulin.
  • Insulin lispro is identical in structure to human insulin except for amino acids 28 and 29 of the B-chain. The analogue has Lys(B28) and Pro(B29) instead of Pro(B28) and Lys(B29) in human insulin.

  Human insulin has a characteristic tertiary structure consisting of two polypeptide chains, the A-chain and B-chain, connected by disulfide bridges. The A-chain forms an α-helix and a β-sheet, while the B-chain forms two α-helices. This overall ring-like structure is likely conserved in insulin lispro as well, since the amino acid substitution is relatively minor.

  Key Benefits

  1. Dual-Action Insulin Profile:
     • Humalog Mix 50 contains a 50/50 blend of fast-acting insulin lispro and long-acting insulin lispro protamine.
     • This provides both rapid control of blood sugar after meals and extended basal insulin coverage.
  2. Convenient Pen Delivery:
     • The Humalog Mix 50 is available in a pre-filled, disposable pen device.
     • This makes it easy for patients to accurately dose and administer the insulin without the need for vials and syringes.
  3. Potential Cost Savings:
     • Importing the insulin from Turkey could potentially offer cost savings compared to purchasing the product domestically.

  Key Ingredients

  1. Insulin Lispro Injection:
     • Molecular formula: C257H383N65O77S6
     • Molecular weight: 5808
     • Insulin lispro is identical to human insulin except for amino acids 28 and 29 of the B-chain.
  2. Insulin Lispro Protamine Suspension:
     • Provides the extended, intermediate-acting profile of Humalog Mix 50.
  3. Other Ingredients:
     • Glycerin, dibasic sodium phosphate, m-cresol, zinc oxide, phenol, and water for injection.
     • The pH is adjusted to 7.0-7.8 using hydrochloric acid and/or sodium hydroxide.

  Dosage

  • Inject Humalog Mix 50/50 subcutaneously within 15 minutes before a meal
  • Dosage should be individualized based on the patient’s metabolic needs, blood glucose monitoring results, and glycemic control goal
  • Typically dosed twice-daily, with each dose intended to cover 2 meals or a meal and a snack
  • When switching from another insulin, a different dosage of Humalog Mix 50/50 may be needed
  • Dosage adjustments may be needed with changes in physical activity, meal patterns, renal/hepatic function, or during acute illness

  Storage

  • Store unopened Humalog Mix 50/50 in the refrigerator at 36°F to 46°F (2°C to 8°C)
  • Do not freeze and do not use if it has been frozen
  • Opened (in-use) vials can be stored at room temperature for 28 days
  • Opened (in-use) KwikPen can be stored at room temperature for 10 days
  • Protect from direct heat and light

  Reviews

  The search results do not contain any information about reviews or user ratings for Humalog Mix 50/50 Insulin. The information focuses more on the dosage, administration, storage, and pharmacokinetics of the medication.