0307-7532291/0320-6421093                                                                                                         Mechanism of action                                                                                                                      Jardiance 25mg tablet is an effective medication used to manage type 2 diabetes and reduce the risk of cardiovascular disease and heart failure in adults with diabetes. The key points about its mechanism of action are:

• Jardiance contains the active ingredient empagliflozin, which is a sodium-glucose co-transporter 2 (SGLT-2) inhibitor.
• By inhibiting SGLT-2, empagliflozin reduces glucose reabsorption in the proximal renal tubules, leading to increased urinary glucose excretion and lowered blood glucose levels.
• In addition to its glucose-lowering effects, empagliflozin has been shown to provide cardiovascular and renal benefits in patients with type 2 diabetes.
• The SGLT-2 inhibition by empagliflozin also helps reduce the risk of cardiovascular death and hospitalization for heart failure in adults with type 2 diabetes and established cardiovascular disease.
• Empagliflozin works independently of insulin secretion and action, making it an effective treatment option for managing diabetes even in insulin-resistant patients.
  Empagliflozin

  Antidiabetic Medication

  More

  Trade Names

  Jardiance, others

  Use

  Improves glucose control in type 2 diabetes

  Side Effects

  Include hyperventilation, abdominal pain, yeast infections

  The chemical structure of empagliflozin, the active ingredient in Jardiance 25mg tablets, is as follows:

  Chemical name: (1S)-1,5-anhydro-1-(4-chloro-3-{4-[(3S)-tetrahydrofuran-3-yloxy]benzyl}phenyl)-D-glucitol
Molecular formula: C23H27ClO7
Molecular weight: 450.91 g/mol


  Key features of the chemical structure:

  • It is a chloro-substituted biphenyl derivative with a tetrahydrofuran ring attached to one of the phenyl groups.
  • The glucitol moiety is attached to the other phenyl ring, forming a cyclic acetal.
  • The molecular formula C23H27ClO7 indicates the presence of 23 carbon atoms, 27 hydrogen atoms, 1 chlorine atom, and 7 oxygen atoms in the molecule.
  • The molecular weight of 450.91 g/mol suggests a relatively large and complex structure compared to many other oral antidiabetic agents.