Description

Levemir Flex Insulin Pen 5’ct Imported Turkey is a long-acting insulin product used to treat diabetes mellitus. It is a prefilled insulin pen containing the insulin detemir, which has a prolonged duration of effect compared to regular insulin.The key details about this product are:

• It is a 5-count package of Levemir Flex Insulin Pens imported from Turkey.
• Levemir is a soluble, long-acting insulin analogue with a prolonged duration of effect, used as a basal insulin to control blood sugar levels.
• The insulin detemir in Levemir facilitates the uptake of glucose, helping to manage diabetes.
• Levemir is administered via subcutaneous injection, typically once or twice daily.
• Potential side effects include hypoglycemia, disorientation, seizures, skin reactions at the injection site, and others.
• Levemir is contraindicated in patients with hypersensitivity to insulin detemir or its excipients.
  

  Imported from Turkey

  This particular Levemir Flex Insulin Pen product is imported from Turkey, rather than being manufactured domestically. This could mean it has some differences compared to versions sold in other countries.

  5-Count Package

  The product comes in a 5-count package, which is a less common packaging size compared to the more typical 1-count or 3-count insulin pen packages. The 5-count packaging may be convenient for some users.

  Flex Pen Design

  The Levemir product is in a “Flex Pen” format, which likely refers to an ergonomic pen-style injector device that is easier to use and handle compared to traditional vial-and-syringe insulin administration.

  Long-Acting Insulin Analogue

  The active ingredient in this product is insulin detemir, which is a long-acting insulin analogue. This provides a more prolonged glucose-lowering effect compared to regular human insulin formulations.

  Key Benefits

  • Long-acting insulin analogue that provides prolonged glucose control
  • Can be used alone as basal insulin or in combination with bolus insulin or oral antidiabetic medications
  • Provides relatively constant insulin levels with no pronounced peak
  • May be administered without regard to meals
  • Has a long duration of action up to 24 hours
  • Lower risk of nighttime hypoglycemia compared to NPH insulin
  • Slightly less weight gain compared to Lantus insulin when used as add-on therapy for type 2 diabetes

  Key Ingredients

  The active ingredient in Levemir Flex Insulin Pen is insulin detemir, which is produced by recombinant DNA technology. The pen contains 100 units/mL of insulin detemir.The inactive ingredients include:

  • Glycerol
  • Phenol
  • Metacresol
  • Zinc acetate
  • Sodium chloride
  • Dibasic sodium phosphate dihydrate
  • Sodium hydroxide
  • Hydrochloric acid
  • Water for injections
    

    Mechanism of Action

    The prolonged action of Levemir is mediated by the strong self-association of insulin detemir molecules at the injection site and albumin binding via the fatty acid component of the insulin detemir molecule .Specifically:

    • Insulin detemir is a long-acting insulin analogue produced by recombinant DNA technology.
    • The fatty acid component of insulin detemir facilitates its binding to albumin in the bloodstream.
    • This albumin binding, along with the self-association of insulin detemir molecules at the injection site, results in a prolonged duration of action compared to regular human insulin.
    • The prolonged action allows Levemir to be used as a basal insulin to provide a relatively constant level of insulin over 24 hours.
    • The blood glucose lowering effect of Levemir is due to the facilitated uptake of glucose following binding of insulin detemir to insulin receptors .
    

    Chemical structure

    Spatial arrangement of atoms in a molecule and their chemical bonds

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    Definition

    The spatial arrangement of atoms within a molecule and the chemical bonds that hold the atoms together.

    Components

    Includes specifying the molecular geometry, electronic structure, and when necessary, the occupation of the molecule’s molecular orbitals.

    Representation

    Represented using structural formulae and molecular models. Precise determination of bond lengths, angles, and torsion angles.

    Based on the search results, the key information about the chemical structure of Levemir (insulin detemir) is:

    Chemical Structure of Insulin Detemir

    Insulin detemir, the active ingredient in Levemir, has the following chemical structure:

    • It is a long-acting insulin analogue produced by recombinant DNA technology.
    • The insulin detemir molecule has a fatty acid (myristic acid) attached to the lysine amino acid at position B29 of the insulin molecule.
    • This fatty acid component allows insulin detemir to bind to albumin in the bloodstream.
    • The self-association of insulin detemir molecules at the injection site, combined with the albumin binding, results in a prolonged duration of action compared to regular human insulin.
    • The prolonged action profile allows insulin detemir to be used as a basal insulin to provide relatively constant insulin levels over 24 hours.
    • The binding of insulin detemir to insulin receptors facilitates the uptake of glucose, leading to the blood glucose lowering effect.

    Dosage

    The recommended dosage of Levemir Flex Insulin Pen is:

    • Levemir is a long-acting insulin that is usually injected once or twice daily.
    • If injecting twice daily, the first dose is usually in the morning and the second dose is with the evening meal, at bedtime, or 12 hours after the morning dose.
    • Levemir should be dosed according to the individual patient’s needs and adjusted based on blood glucose monitoring.
    • Levemir should not be mixed with any other insulin products.

    Storage

    Proper storage of Levemir Flex Insulin Pen is important:

    • Before opening, Levemir should be stored in a refrigerator between 2°C and 8°C.
    • After first use or when used as a spare, Levemir FlexPen can be kept at room temperature below 30°C or refrigerated for up to 6 weeks.
    • Levemir should not be frozen or exposed to excessive heat or light.
    • Opened insulin detemir cartridges and pens can only be stored at room temperature and should not be refrigerated.
    • Levemir should be discarded 42 days after first use, even if the vial or pen still contains insulin.

    Reviews

    Levemir has generally positive reviews from patients:

    • Levemir provides effective 24-hour blood sugar control with a single daily injection.
    • Patients report stable blood sugar levels and fewer episodes of hypoglycemia compared to other basal insulins.
    • The FlexPen device is easy to use and allows for accurate dosing.
    • Some patients experience mild injection site reactions like redness or swelling, but these are generally well-tolerated.