Description

Lipitor (Atorvastatin) 10mg 30’ct tablet is a prescription medication used to lower cholesterol levels in the blood. Atorvastatin, the active ingredient in Lipitor, belongs to a class of drugs called statins that work by inhibiting an enzyme involved in the production of cholesterol.The key facts about this Lipitor product are:Composition

• Each film-coated tablet contains 10 mg of atorvastatin (as atorvastatin calcium trihydrate) 
• The tablets also contain lactose monohydrate and benzoic acid as excipients 

Indications

• Lipitor 10mg is indicated for the treatment of hypercholesterolemia (high cholesterol) and to reduce the risk of cardiovascular disease in adults 
• It can be used in adolescents and children aged 10 years or older with primary hypercholesterolemia 

Dosage

• The usual starting dose is 10 mg once daily, with the maximum dose being 80 mg once daily 
• The dose should be individualized based on the patient’s baseline LDL-C levels, treatment goals, and response 

Pharmacology

• Atorvastatin works by inhibiting an enzyme involved in the production of cholesterol, leading to a reduction in blood cholesterol levels 
• A therapeutic response is typically evident within 2 weeks, with the maximum effect seen within 4 weeks                                                                                                                            Here are the key unique details about Lipitor (Atorvastatin) 10mg 30’ct tablet:
  • Each film-coated tablet contains 10 mg of atorvastatin (as atorvastatin calcium trihydrate) and the excipients lactose monohydrate and benzoic acid
  • The tablets are white, elliptical, film-coated with “PD 155” on one side and “10” on the other
  • It is supplied in bottles of 90 tablets with NDC 0071-0155-23 or in 10 x 10 unit dose blisters with NDC 0071-0155-40
  • The tablets should be stored at controlled room temperature 20-25°C (68-77°F)
  • Lipitor 10mg is indicated for hyperlipidemia, hyperlipoproteinemia types IIa, IIb, III, IV, homozygous and heterozygous familial hypercholesterolemia, hypertriglyceridemia, and prevention of cardiovascular disease
  • The usual starting dose is 10 mg once daily, with a maximum dose of 80 mg once daily. The dose should be individualized based on the patient’s baseline LDL-C, treatment goals, and response

  Key Benefits

  • Lowers cholesterol levels, including total cholesterol, LDL-cholesterol, and triglycerides 
  • Reduces the risk of cardiovascular disease, such as heart attack and stroke, in adults 
  • Can be used to treat various types of hypercholesterolemia, including familial hypercholesterolemia 
  • Effective at lowering cholesterol, with a therapeutic response evident within 2 weeks and maximum effect seen within 4 weeks 

  Key Ingredients

  • Each film-coated tablet contains 10 mg of atorvastatin (as atorvastatin calcium trihydrate) as the active ingredient 
  • The excipients are lactose monohydrate and benzoic acid 
  • The tablets are white, elliptical, and film-coated with “PD 155” on one side and “10” on the other 

  Lipitor (atorvastatin) lowers cholesterol levels by inhibiting the enzyme HMG-CoA reductase, which is the rate-limiting step in cholesterol biosynthesis. Specifically:

  • Atorvastatin is a competitive inhibitor of HMG-CoA reductase, which catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol synthesis.
  • By inhibiting this enzyme, atorvastatin reduces endogenous cholesterol production, particularly in the liver which is the primary site of action.
  • Decreased hepatic cholesterol concentrations stimulate upregulation of hepatic LDL receptors, increasing hepatic uptake and catabolism of LDL.
  • Atorvastatin also reduces VLDL-C, serum triglycerides, IDL, and apolipoprotein B containing particles, while increasing HDL-C.

  In addition to its lipid-lowering effects, atorvastatin and other statins have been shown to have pleiotropic effects independent of cholesterol lowering, such as improving endothelial function, enhancing plaque stability, reducing oxidative stress and inflammation, and inhibiting thrombogenesis.                                                                                                     

  

  Atorvastatin

  Statin medication

  More

  Primary use

  Prevention of cardiovascular disease and treatment of abnormal lipid levels

  Trade names

  Lipitor, others

  Routes of administration

  By mouth

  The chemical structure of atorvastatin, the active ingredient in Lipitor, is:Chemical structure of atorvastatinKey features of the structure:

  • It is a pentasubstituted pyrrole formed by two contrasting moieties with an achiral heterocyclic core unit and a 3,5-dihydroxypentanoyl side chain
  • The molecular formula is C33H35FN2O5
  • It has two defined stereocenters with (3R,5R) configuration
  • The IUPAC name is (3R,5R)-7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid

  Dosage

  • The recommended starting dosage of Lipitor is 10-20 mg once daily
  • The dosage range is 10-80 mg once daily
  • Patients who require LDL-C reduction >45% may start at 40 mg once daily
  • Lipitor can be administered as a single dose at any time of day, with or without food

  Storage

  • Lipitor oral tablets should be stored at controlled room temperature 20-25°C (68-77°F)
  • They can be exposed to temperatures between 15-30°C (59-86°F) for shorter periods, such as when transporting
  • Store in a cool, dry place in the original bottle or packaging

  Reviews

  • In a 26-week double-blind placebo-controlled study in adolescents with heterozygous familial hypercholesterolemia or severe hypercholesterolemia, Lipitor 10-20 mg significantly decreased total-C, LDL-C, triglycerides, and apolipoprotein B compared to placebo
  • The mean achieved LDL-C level was 130.7 mg/dL in the Lipitor group compared to 228.5 mg/dL in the placebo group
  • In a 3-year open-label uncontrolled study in children 10-15 years old with heterozygous familial hypercholesterolemia, the starting Lipitor dose was 10 mg once daily, adjusted to achieve LDL-C <130 mg/dL. Reductions in LDL-C were generally consistent with previous adult and pediatric placebo-controlled trials