Morphine sulphate 10mg 30’ct tab (Magnus Mr)
Morphine sulphate 10mg 30’ct tab (Magnus Mr) is a prescription opioid medication used to treat moderate to severe pain. The key points about this medication are:Morphine is a potent opioid analgesic that works by binding to opioid receptors in the brain and spinal cord to reduce the perception of pain. It is typically administered orally, intravenously, or via other routes.The 10mg tablet formulation is an immediate-release version of morphine sulfate, meaning it provides rapid pain relief but has a shorter duration of action compared to extended-release formulations. The “30’ct” indicates a package size of 30 tablets.The “Magnus Mr” refers to the manufacturer or brand name of this specific morphine sulfate product. Morphine is available from multiple manufacturers and in various formulations.Opioid medications like morphine have a risk of dependence, addiction, and overdose, so they are tightly regulated and typically only prescribed for severe, acute pain or for palliative/end-of-life care.
Morphine sulfate is often prescribed for pain relief in various medical conditions, such as post-surgical pain, cancer pain, and severe injuries.
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Description
Morphine sulphate 10mg 30’ct tab (Magnus Mr) is a prescription opioid medication used to treat moderate to severe pain. The key points about this medication are:Morphine is a potent opioid analgesic that works by binding to opioid receptors in the brain and spinal cord to reduce the perception of pain. It is typically administered orally, intravenously, or via other routes.The 10mg tablet formulation is an immediate-release version of morphine sulfate, meaning it provides rapid pain relief but has a shorter duration of action compared to extended-release formulations. The “30’ct” indicates a package size of 30 tablets.The “Magnus Mr” refers to the manufacturer or brand name of this specific morphine sulfate product. Morphine is available from multiple manufacturers and in various formulations.Opioid medications like morphine have a risk of dependence, addiction, and overdose, so they are tightly regulated and typically only prescribed for severe, acute pain or for palliative/end-of-life care.
Composition
- Each tablet contains 10mg of morphine sulfate as the active ingredient.
- The formulation is immediate-release, providing rapid pain relief.
Dosage and Administration
- Taken orally as directed by a healthcare provider.
- Dosage is individualized based on pain severity, patient response, and prior opioid exposure.
Indications and Usage
- Indicated for the management of moderate to severe pain in opioid-tolerant patients.
- Not suitable for the treatment of mild pain or as an as-needed analgesic.
Contraindications
- Hypersensitivity to morphine or any component of the formulation.
- Significant respiratory depression.
- Acute or severe bronchial asthma.
- Known or suspected paralytic ileus.
Warnings and Precautions
- Risk of addiction, abuse, and misuse, which can lead to overdose and death.
- Respiratory depression, particularly in elderly, cachectic, or debilitated patients.
- Interactions with central nervous system depressants, including alcohol and benzodiazepines.
- Increased risk of neonatal opioid withdrawal syndrome with prolonged use during pregnancy.
Adverse Reactions
- Common adverse reactions include constipation, nausea, vomiting, dizziness, and drowsiness.
- Serious adverse reactions include respiratory depression, hypotension, and seizures.
How Supplied
- Available as 10mg immediate-release tablets in bottles of 30 count (30’ct).
- Stored at controlled room temperature, protected from moisture and light.
Benefits:
- Provides rapid pain relief for moderate to severe pain in opioid-tolerant patients
- Immediate-release formulation allows for flexible dosing and titration
- Indicated for the management of pain when a continuous, around-the-clock opioid analgesic is needed
Key Ingredients:
- Each tablet contains 10mg of morphine sulfate as the active pharmaceutical ingredient
- The formulation does not contain any other active ingredients, only standard inactive excipients like cellulose, magnesium stearate, etc. to facilitate tablet manufacturing and stability
Morphine Sulfate 10mg 30’ct Tab (Magnus Mr) works through the following mechanism of action:Morphine is a potent opioid agonist that primarily acts on the mu-opioid receptors in the central nervous system. Binding to these receptors blocks the transmission of nociceptive (pain) signals, modulates pain-signaling neurons in the spinal cord, and inhibits primary afferent nociceptors.Morphine’s activation of the mu-opioid receptors in the ventral tegmental area of the brain also mediates its analgesic (pain-relieving) and rewarding effects. Additionally, morphine interacts with delta-opioid receptors in the nucleus accumbens, which contributes to its effects on the reward pathway.By targeting these key opioid receptors, morphine is able to effectively reduce the perception and emotional response to pain. This makes it a potent analgesic medication for the management of moderate to severe pain in opioid-tolerant patients.
Chemical Structure
Morphine sulfate is the sulfate salt of the opioid analgesic drug morphine. The chemical structure can be represented as:
The key structural features are:
- The morphine base molecule, which consists of a tetracyclic structure with an ether bridge, a phenol group, and a secondary amine.
- The sulfate counterion, which forms a 2:1 salt with the morphine base.
- Five water molecules of hydration in the pentahydrate form.
Morphine Sulfate Ring Structure
The morphine sulfate molecule has a complex ring structure consisting of multiple fused rings:Tetracyclic Ring System
The core of the morphine molecule is a tetracyclic ring system, composed of:
- A phenanthrene ring system (3 fused rings)
- An additional heterocyclic ring containing a nitrogen atom
Ether Bridge
An ether bridge connects two of the rings in the tetracyclic system, forming a characteristic morphinan skeleton.Sulfate Counterion
The morphine base forms a 2:1 salt with the sulfate counterion, which is not part of the core ring structure.Hydration
In the pentahydrate form, there are 5 water molecules associated with the morphine sulfate structure.
Dosage
- Initial Dose: The recommended initial dose for Morphine Sulfate 10mg 30’ct Tab (Magnus Mr) is 10 mg every 4 hours as needed for acute pain and every 4 hours around the clock for chronic pain.
- Elderly and Debilitated Patients: For elderly and debilitated patients, the initial dose should be half the usual recommended dose due to the depressant effect on respiration.
- Patients Currently Receiving Opioids: For patients currently receiving other opioids, the dosage should be based on the patient’s prior analgesic treatment and response. The “oral morphine sulfate equivalent” of the analgesic presently being used should be determined, and the dosage should be adjusted accordingly.
- Dose Titration: Dose titration is crucial to ensure the patient’s pain is adequately managed with minimal side effects. The dosage should be adjusted based on the patient’s clinical response, with higher doses justified in some patients to cover periods of physical activity.
Storage and Handling
- Storage: Store Morphine Sulfate 10mg 30’ct Tab (Magnus Mr) at controlled room temperature and protect from moisture and light.
- Handling: Handle Morphine Sulfate 10mg 30’ct Tab (Magnus Mr) with care, as it is a controlled substance with a high potential for abuse and misuse. Patients and their families should be instructed to flush any unneeded tablets down the toilet to prevent diversion and misuse.
Reviews
- Patient Reviews: Patient reviews for Morphine Sulfate 10mg 30’ct Tab (Magnus Mr) are generally positive, with patients reporting effective pain relief and improved quality of life. However, some patients may experience side effects such as dizziness, nausea, and constipation.
- Healthcare Professional Reviews: Healthcare professionals generally recommend Morphine Sulfate 10mg 30’ct Tab (Magnus Mr) for its efficacy in managing moderate to severe pain. However, they also emphasize the importance of proper dosing and titration to minimize side effects and prevent overdose.
Important Safety Information
- Respiratory Depression: Morphine Sulfate 10mg 30’ct Tab (Magnus Mr) can cause respiratory depression, particularly in elderly and debilitated patients. Monitor patients closely for signs of respiratory depression and adjust the dosage accordingly.
- Addiction and Abuse: Morphine Sulfate 10mg 30’ct Tab (Magnus Mr) is a controlled substance with a high potential for abuse and addiction. Patients should be closely monitored for signs of addiction and abuse, and the dosage should be adjusted accordingly.
Important Dosage and Administration Instructions
- Initiation: Initiate dosing using Morphine Sulfate 10mg 30’ct Tab (Magnus Mr) at a dose of 10 mg every 4 hours as needed for acute pain and every 4 hours around the clock for chronic pain.
- Conversion: For patients currently receiving other opioids, convert to Morphine Sulfate 10mg 30’ct Tab (Magnus Mr) by administering one-half of the patient’s 24-hour requirement as Morphine Sulfate 10mg 30’ct Tab (Magnus Mr) on an every-12-hour schedule or by administering one-third of the patient’s daily requirement as Morphine Sulfate 10mg 30’ct Tab (Magnus Mr) on an every-8-hour schedule.
Important Safety Information
- Overdose: Overdose with Morphine Sulfate 10mg 30’ct Tab (Magnus Mr) can be fatal. Monitor patients closely for signs of overdose and adjust the dosage accordingly.
- Withdrawal: When discontinuing Morphine Sulfate 10mg 30’ct Tab (Magnus Mr), taper the dose gradually to prevent symptoms of withdrawal.
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