Description

Availability in Pakistan

Nicorette Original 4mg 210’s gum is available in Pakistan and can be purchased from various online retailers such as Vitamin Collection.

Key Features

• Each piece contains 4mg of nicotine to help relieve withdrawal symptoms and cravings for those who smoke more than 20 cigarettes per day
• Comes in a pack of 210 pieces
• Product of UK
• Helps gradually reduce nicotine intake while adjusting to a smoke-free lifestyle

Usage Instructions

To use Nicorette gum effectively, chew a piece whenever you feel an urge to smoke, but no more than 15 pieces per day. Chew the gum until the taste becomes strong, then rest it between your gum and cheek until the taste fades. Repeat this process for up to 30 minutes.Nicorette gum is a medicine, so it’s important to follow the proper chewing technique to avoid releasing the nicotine too quickly and experiencing potential side effects like an irritated throat, upset stomach, or hiccups.

Using Nicorette Original 4mg 210’s Gum During Pregnancy

Key Points:

• Nicorette gum can be used during pregnancy, but it’s best to speak to your doctor or pharmacist first before taking any nicotine replacement therapy .
• Smoking during pregnancy can seriously harm your baby, so using Nicorette gum is considered a safer alternative than continuing to smoke .
• Fast-acting nicotine replacement products like gum may be preferable over slow-release patches when pregnant, as they can help satisfy cravings more quickly .
• It’s recommended to use Nicorette gum intermittently and try to reduce your nicotine intake as much as possible during pregnancy .
• Nicorette 4mg gum is suitable for heavier smokers who smoke more than 20 cigarettes per day .

The Effects of Nicotine from Gum on the Fetus

Based on the search results, the key points regarding the effects of nicotine from gum on the fetus are:Nicotine Exposure and Fetal Health

• Nicotine from gum can readily cross the placenta and reach the fetus, with fetal concentrations generally 15% higher than maternal levels .
• Nicotine exposure during pregnancy is associated with increased risks of spontaneous abortion, premature delivery, and decreased birth weight .
• Animal studies have shown that fetal and neonatal nicotine exposure can lead to long-term adverse effects on the offspring, including impaired fertility, metabolic disorders, cardiovascular problems, and neurobehavioral deficits .

Risks of Nicotine Replacement Therapy (NRT) During Pregnancy

• While NRT like nicotine gum is considered safer than continued smoking, the long-term effects on the developing fetus are not fully known .
• Healthcare providers recommend trying to quit smoking without NRT first, as the risks to the child from nicotine gum are not fully understood .
• If using NRT during pregnancy, it should only be done under the guidance and supervision of a healthcare provider .

Key Benefits

• Helps control nicotine cravings and withdrawal symptoms associated with quitting smoking
• Slowly releases nicotine to combat cravings and reduce anxiety, frustration, irritability, and restlessness
• Provides a pleasant chewing experience as part of nicotine replacement therapy
• Suitable for heavier smokers who smoke more than 20 cigarettes per day

Key Ingredients

• Nicotine polacrilex (equal to 4mg nicotine) – the active ingredient that acts as a stop-smoking aid
• D&C yellow #10 – a coloring agent
• Flavors
• Glycerin
• Gum base
• Sodium carbonate
• Sorbitol

Mechanism of Action of Nicorette Original 4mg Gum

The key mechanism of action of Nicorette Original 4mg nicotine gum is:Nicotine Receptor Binding and Dopamine Release

• Nicotine in the gum binds to nicotinic acetylcholine receptors (nAChRs) in the brain, particularly in the ventral tegmental area .
• This binding stimulates the release of dopamine in the nucleus accumbens, the brain’s reward center .
• The release of dopamine produces pleasurable feelings and reduces the symptoms of nicotine withdrawal, helping to curb cravings for cigarettes .

Biphasic Nicotine Delivery

• The Nicorette gum is formulated to provide a biphasic nicotine delivery profile :
  1. An initial rapid release of nicotine to quickly relieve cravings and withdrawal symptoms
  2. A more gradual, sustained release of nicotine to maintain blood levels and prevent breakthrough cravings

Buccal Absorption

• The nicotine in the gum is absorbed through the buccal (cheek) mucosa when the gum is chewed and held in the mouth .
• This buccal absorption allows the nicotine to enter the bloodstream directly, bypassing first-pass metabolism in the liver.

Nicotine gum

Chewing gum containing nicotine polacrilex for smoking cessation

More

Active Ingredient

Nicotine polacrilex

Availability

Available without a prescription

Flavors and Strengths

Flavors range from mint to fruit, doses typically 2-4 mg

Chemical Structure of Nicotine

Nicotine, the active ingredient in Nicorette Original 4mg gum, has the following chemical structure:Nicotine Chemical StructureKey features of nicotine’s chemical structure:

• It is a tertiary amine consisting of a pyridine ring and a pyrrolidine ring
• The pyrrolidine ring contains a basic nitrogen atom with a lone pair of electrons
• The pyridine ring is aromatic and contains a secondary amine group
• The two rings are connected by a carbon-carbon bond

Dosage

• The recommended dosage for Nicorette Original 4mg gum is:
  • If you smoke your first cigarette within 30 minutes of waking up, use the 4mg nicotine gum
  • Chew one piece slowly until the taste becomes strong, then park it between your cheek and gum
  • Repeat this process for up to 30 minutes per piece
  • Use at least 9 pieces per day for the first 6 weeks to improve your chances of quitting
  • Do not exceed 24 pieces per day

Storage

• Store Nicorette Original 4mg gum below 25°C (77°F) in the original packaging
• Keep out of sight and reach of children
• Do not use the gum after the expiration date printed on the package

Reviews

• Nicorette Original 4mg gum has generally positive reviews, with users reporting that it helps manage cravings and withdrawal symptoms when quitting smoking 
• Some users note the gum has a strong taste and can cause mouth/throat irritation, but these side effects are manageable 
• Many users find the ‘chew and park’ method effective for slowly releasing the nicotine 
• Overall, the Nicorette 4mg gum is considered an effective nicotine replacement therapy to support smoking cessation efforts 

Key Precautions for Using Nicorette Original 4mg 210’s Gum

Based on the search results, here are the key precautions to consider when using Nicorette Original 4mg nicotine gum:Medical Conditions

• Do not use Nicorette gum if you have a sodium-restricted diet, heart disease, recent heart attack, irregular heartbeat, or uncontrolled high blood pressure 
• Use caution if you have a stomach ulcer, diabetes, or a history of seizures 

Interactions

• Inform your doctor if you are using any other non-nicotine stop smoking medications or prescription drugs for depression or asthma, as the dosage may need to be adjusted 

Proper Use

• Do not eat or drink for 15 minutes before or while using the Nicorette gum, as this can reduce its effectiveness 
• Follow the proper chewing technique of chewing, parking, and re-chewing to slowly release the nicotine 
• Do not exceed 24 pieces of Nicorette gum per day 

Side Effects

• Stop using the Nicorette gum and consult a doctor if you experience any mouth, teeth, or jaw problems 
• Seek immediate medical attention if a child under 12 accidentally ingests the Nicorette gum, as it can cause severe nicotine poisoning 

Use Caution if You Have Heart Disease

• Nicorette Gum should be used with caution if you have heart disease, including:
  • Recent heart attack
  • Irregular heartbeat or arrhythmia
  • Stroke
• Nicotine from the gum can increase your heart rate and blood pressure, so it’s important to use it under the guidance of your doctor if you have any of these conditions.

Consult Your Doctor First

• Talk to your doctor before using Nicorette Gum if you have heart disease or have recently had a heart attack.
• Your doctor can help determine if the benefits of using Nicorette Gum outweigh the potential risks for your specific situation.
• They may recommend starting at a lower nicotine dose or using an alternative nicotine replacement therapy.

Potential Side Effects to Monitor

• Stop using Nicorette Gum and seek medical attention if you experience any irregular heartbeats, palpitations, or other heart-related side effects.
• Other potential side effects to watch for include chest pain, shortness of breath, and high blood pressure.

Use During Pregnancy

• Nicorette gum can be used during pregnancy, but it’s best to consult your doctor or pharmacist first before taking any nicotine replacement therapy.
• Smoking during pregnancy can seriously harm the baby, so using Nicorette gum is considered a safer alternative than continued smoking.
• Fast-acting nicotine replacement products like gum may be preferable over slow-release patches when pregnant, as they can help satisfy cravings more quickly.
• It’s recommended to use Nicorette gum intermittently and try to reduce your nicotine intake as much as possible during pregnancy.

Use During Breastfeeding

• Nicorette gum can be used while breastfeeding, but it’s important to follow some precautions:
  • Breastfeed before using the gum to minimize the baby’s nicotine exposure.
  • Use the gum immediately after breastfeeding, as nicotine gum produces rapid, high nicotine levels.
  • Nicotine patches may be preferable as they provide a more sustained, lower level of nicotine.
• Using Nicorette gum is considered safer than continued smoking while breastfeeding.