Nicorette Orignal 2mg 105’ct Nicotine Gum
Nicorette Original 2mg Nicotine Gum
Product Overview
- Type: Nicotine Replacement Therapy (NRT)
- Strength: 2mg of nicotine per piece
- Quantity: 105 pieces per pack
Recommended Use
- Target Audience: Smokers who consume 20 cigarettes or fewer per day.
- Initial Dosage: Chew at least 9 pieces daily for the first 6 weeks.
- Chewing Instructions:
- Chew slowly until the flavor intensifies.
- Park the gum between the gum and cheek to allow nicotine absorption.
- Maximum of 15 pieces per day.
Benefits
- Craving Control: Helps manage cravings and withdrawal symptoms.
- Nicotine Delivery: Provides a controlled dose of nicotine to ease the transition to non-smoking.
- Sugar-Free: Suitable for those concerned about sugar intake.
- Flavor: Available in a classic original flavor.
Pricing and Availability
- Retail Prices:
- Approximately $32.95 for a single pack on eBay (with free shipping).
- $61.99 for three packs of 105 pieces.
- International Pricing: Available in Pakistan for around ₨6,000.00.
Usage Instructions
- Storage: Store at room temperature, away from heat and moisture, and out of reach of children.
- Consultation: Consult a healthcare provider for personalized guidance, especially for pregnant individuals or those with pre-existing health conditions.
Conclusion
Nicorette Original 2mg nicotine gum is a valuable resource for individuals looking to quit smoking, offering both physical and psychological support through its structured nicotine delivery system.
Original price was: ₨15,000.00.₨9,999.00Current price is: ₨9,999.00.
Description
Nicorette Original 2mg Nicotine Gum
Product Overview
- Type: Nicotine Replacement Therapy (NRT)
- Strength: 2mg of nicotine per piece
- Quantity: 105 pieces per pack
Recommended Use
- Target Audience: Smokers who consume 20 cigarettes or fewer per day.
- Initial Dosage: Chew at least 9 pieces daily for the first 6 weeks.
- Chewing Instructions:
- Chew slowly until the flavor intensifies.
- Park the gum between the gum and cheek to allow nicotine absorption.
- Maximum of 15 pieces per day.
Benefits
- Craving Control: Helps manage cravings and withdrawal symptoms.
- Nicotine Delivery: Provides a controlled dose of nicotine to ease the transition to non-smoking.
- Sugar-Free: Suitable for those concerned about sugar intake.
- Flavor: Available in a classic original flavor.
Pricing and Availability
- Retail Prices:
- Approximately $32.95 for a single pack on eBay (with free shipping).
- $61.99 for three packs of 105 pieces.
- International Pricing: Available in Pakistan for around ₨6,000.00.
Usage Instructions
- Storage: Store at room temperature, away from heat and moisture, and out of reach of children.
- Consultation: Consult a healthcare provider for personalized guidance, especially for pregnant individuals or those with pre-existing health conditions.
Conclusion
Nicorette Original 2mg nicotine gum is a valuable resource for individuals looking to quit smoking, offering both physical and psychological support through its structured nicotine delivery system.
Key Benefits of Nicorette Original 2mg Nicotine Gum
- Craving Relief: Effectively relieves and prevents withdrawal symptoms and cravings associated with quitting smoking.
- Increased Success Rates: Doubles the chances of successfully quitting smoking when used as part of a comprehensive cessation program.
- Flexible Usage: Can be used to completely replace cigarettes or to reduce the number of cigarettes smoked, aiding in gradual cessation.
- Therapeutic Nicotine Delivery: Releases a small therapeutic dose of nicotine that is slowly absorbed through the mouth, helping to manage daily nicotine intake.
- Convenience: Portable and easy to use, allowing users to chew a second piece within the hour if cravings are strong.
- Improves Motivation: Helps increase motivation to quit smoking by providing a safer alternative to cigarettes.
Key Ingredients
- Active Ingredient:
- Nicotine Polacrilex (equivalent to 2mg of nicotine) – the primary component that aids in smoking cessation.
- Inactive Ingredients:
- Gum Base: Provides the chewy texture.
- Sorbitol: A sugar substitute that adds sweetness.
- Sodium Bicarbonate: Helps maintain pH balance.
- Sodium Carbonate: Used as a buffering agent.
- Glycerin: Adds moisture and improves texture.
- Flavorings: Various flavors to enhance taste, ensuring a more pleasant chewing experience.
Mechanism of Action of Nicorette Original 2mg Nicotine Gum
Nicorette Original 2mg nicotine gum functions primarily as a nicotine replacement therapy (NRT) to assist individuals in quitting smoking. Its mechanism of action involves the following key processes:
Nicotine Delivery
- Controlled Release: When chewed, the gum releases a small, therapeutic dose of nicotine that is absorbed through the mucous membranes in the mouth. This method allows for a gradual and controlled intake of nicotine, which helps to alleviate withdrawal symptoms and cravings associated with quitting smoking.
Binding to Nicotine Receptors
- Activation of Receptors: The nicotine absorbed from the gum binds to nicotinic acetylcholine receptors in the brain. This binding mimics the effects of smoking, providing a sense of relief from cravings and reducing withdrawal symptoms such as anxiety, irritability, and restlessness.
Reduction of Withdrawal Symptoms
- Symptom Management: By providing a steady supply of nicotine, the gum helps to minimize the physical and psychological discomfort that often accompanies nicotine withdrawal. This can include symptoms like cravings, irritability, and difficulty concentrating, making it easier for individuals to focus on their quit plan.
Behavioral Support
- Chewing Action: The act of chewing the gum itself can also serve as a behavioral substitute for smoking, helping to satisfy the oral fixation that many smokers experience. This dual approach—both pharmacological and behavioral—enhances the effectiveness of the gum as a cessation aid.
Recommendations for Use
- Structured Program: For optimal results, users are encouraged to chew at least 9 pieces per day during the initial weeks of their quit program, gradually reducing usage as cravings diminish. This structured approach, combined with willpower and possibly behavioral support, increases the likelihood of successfully quitting smoking.
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Molecular Formula
- C₁₀H₁₄N₂
Chemical Structure
Nicotine is an alkaloid that consists of a pyridine and a pyrrolidine ring. The structure can be depicted as follows:
N
/ \
C C
/ \
H C
\ / \
C---C N
/ \ \
H C---C
/ \
H H
Description
- Pyridine Ring: The nitrogen atom in the pyridine ring contributes to the basic properties of nicotine.
- Pyrrolidine Ring: This part of the molecule is responsible for the psychoactive effects of nicotine.
Function in Nicotine Gum
When Nicorette gum is chewed, nicotine is released and absorbed through the oral mucosa, providing a controlled dose of nicotine to help manage cravings and withdrawal symptoms associated with quitting smoking. The specific formulation in the gum (nicotine polacrilex) is designed to enhance the absorption of nicotine while minimizing the risk of rapid delivery, which can lead to adverse effects. Nicotine polacrilex, the active ingredient in Nicorette Original 2mg nicotine gum, is synthesized by combining nicotine, a cation exchange resin, and water. Here are the key steps in the synthesis process:
Mixing Nicotine, Resin, and Water
- Nicotine and water are mixed together first, then the cation exchange resin (such as Amberlite IRP64) is added.
- The mixture typically contains 5-75% water by weight.
Stirring and Agitation
- The mixture is stirred at high speed for several minutes to ensure thorough combination of the components.
- Agitation helps the nicotine bind to the resin and form the polacrilex complex.
Resin Selection
- Common cation exchange resins used include:
- Methacrylic, weakly acidic resins with carboxylic groups (e.g. Amberlite IRP64)
- Polystyrene, strongly acidic resins with sulfonic groups
- Polystyrene, intermediate acidic resins with phosphonic groups
Typical Formulation
- Nicotine concentration in the mixture is usually 5-50% by weight.
- The weight ratio of resin to nicotine is typically 1:1 to 10:1.
- An organic polyol like glycerol may also be added to the mixture.
Key Precautions for Nicorette Original 2mg Nicotine Gum
- Allergic Reactions: Do not use if you are allergic to nicotine or any of the other ingredients listed in the product.
- Pregnancy and Breastfeeding: Consult a healthcare provider before using if you are pregnant or breastfeeding. Nicotine can affect fetal development and may also be passed to infants through breast milk.
- Age Restrictions: Not recommended for children under 12 years of age. If you are under 18, consult a doctor before use.
- Pre-existing Health Conditions: Talk to your doctor or pharmacist before using if you have a history of heart disease, high blood pressure, or other serious health conditions.
- Dosage Limitations: Do not exceed 15 pieces of gum per day. Overuse can lead to nicotine toxicity.
- Storage Instructions: Keep the gum out of reach of children and store it below 25°C to maintain its effectiveness.
- Consultation for Smoking Cessation: It is advisable to use this product in conjunction with behavioral support or counseling for better chances of quitting smoking successfully.
Dietary Restrictions
- Sugar-Free: Nicorette gum is sugar-free, making it suitable for individuals monitoring their sugar intake.
- Alcohol Consideration: While not explicitly restricted, it is advisable to avoid alcohol consumption while using nicotine gum, as it may increase cravings and reduce the effectiveness of the gum.
- Eating and Drinking: Do not eat or drink for 15 minutes before or during the use of the gum to ensure proper absorption of nicotine.
Combination with Other Nicotine Replacement Therapies
- Nicotine Patch: Nicorette gum can be effectively combined with nicotine patches. The patch provides a steady, long-acting dose of nicotine throughout the day, while the gum offers a quick relief for sudden cravings. This combination can enhance the overall effectiveness of smoking cessation efforts by addressing both constant and acute nicotine needs.
- Other Forms of NRT: Nicorette gum can also be used alongside other NRTs like lozenges or nasal sprays. This allows users to manage cravings more effectively by utilizing both short-acting and long-acting forms of nicotine delivery.
General Considerations
- Consultation Recommended: It is advisable to consult with a healthcare provider before combining Nicorette gum with other medications, especially if you are taking other prescription medications or have underlying health conditions.
- Monitoring for Side Effects: When using multiple forms of NRT, it’s important to monitor for potential side effects, as increased nicotine intake can lead to symptoms of nicotine toxicity, such as nausea, increased heart rate, and dizziness.
Potential Interactions
- Nicotine can increase blood pressure and heart rate, which may be a concern for those taking antihypertensive medications.
- Nicorette gum should be used with caution in those with uncontrolled high blood pressure, as nicotine can further increase blood pressure.
- Patients taking prescription antihypertensive medications should review possible interactions with a doctor before starting nicotine gum.
Recommendations
- Consult with a healthcare provider before using Nicorette gum if you have high blood pressure, especially if it is not well-controlled with medication.
- Work with your doctor to develop a hypertension management plan while using nicotine gum, as you may need to adjust your blood pressure medication dosage.
- Monitor your blood pressure closely when starting Nicorette gum, and report any significant changes to your doctor.
- Use Nicorette gum as part of a comprehensive smoking cessation program that includes behavioral support and counseling for the best chance of quitting successfully.
- Nicorette gum is intended for short-term use only to help manage cravings and withdrawal symptoms when quitting smoking. Long-term use may lead to similar health risks as smoking.
Dosage of Nicorette Original 2mg Nicotine Gum
- Initial Dosage:
- For smokers of 20 cigarettes or fewer per day: Start with 2 mg gum.
- For smokers of more than 20 cigarettes per day: Start with 4 mg gum.
- Recommended Usage:
- Weeks 1-6: Chew 1 piece every 1-2 hours, aiming for at least 9 pieces per day.
- Weeks 7-9: Chew 1 piece every 2-4 hours.
- Weeks 10-12: Chew 1 piece every 4-8 hours.
- Additional Notes: If cravings are strong, a second piece may be used within one hour. Do not exceed 15 pieces of gum per day.
Storage Instructions
- Store Nicorette gum in its original packaging to protect it from light and moisture.
- Temperature: Do not store above 25°C (77°F) to maintain effectiveness.
Reviews and User Feedback
- General Sentiment: Many users report that Nicorette gum is effective in managing cravings and withdrawal symptoms associated with quitting smoking. It provides a convenient way to control nicotine intake and helps users transition away from cigarettes.
- Positive Aspects: Users appreciate the gum’s ability to satisfy oral fixation and the flexibility it offers in terms of dosage. Many find it easy to use and effective for on-the-go cravings.
- Negative Feedback: Some users have noted side effects such as mouth irritation, hiccups, or gastrointestinal discomfort. A few reviews mention that the gum can be tough to chew or that the taste may not be appealing to everyone
Nicorette Original 2mg nicotine gum is a moderately effective tool for quitting smoking when used as directed. Here are the key points about its efficacy:
Doubles Quit Rates vs Placebo
- The use of 4mg nicotine gum more than tripled quit rates compared to placebo at 30 days among highly dependent smokers (those who smoke their first cigarette within 30 minutes of waking).
- Abstinence rates with Nicorette gum were statistically significantly different from placebo.
Efficacy Depends on Nicotine Dependence
- Nicotine gum is more effective in highly dependent smokers, with an efficacy of 16% (7% to 25%) in this group.
- In less dependent smokers, there was no significant effect of the 2mg gum.
- The 4mg gum was effective in about one third of highly dependent smokers.
Increases Chances of Quitting
- Nicorette gum doubles the chances of successfully quitting smoking when used as part of a comprehensive cessation program.
- Nicotine gum delivers a controlled dose of nicotine to help alleviate cravings and withdrawal symptoms, making it easier to quit.
- Initial Dosage:
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