Description

Sandimmun Neoral 100mg is a medication used to prevent organ rejection in people who have had an organ transplant. It is also used to treat severe cases of rheumatoid arthritis and psoriasis.The key points about Sandimmun Neoral 100mg 50’ct are:

• It is a capsule formulation containing 100mg of the active ingredient cyclosporine.
• It is used to reduce the risk of organ rejection in transplant patients by suppressing the immune system.
• It can also be used to treat severe cases of rheumatoid arthritis and psoriasis by reducing inflammation.
• Common side effects include kidney problems, high blood pressure, tremors, and increased risk of infections and certain cancers.
• Patients need to be closely monitored with regular blood tests while taking this medication.
• Proper storage, dosing, and precautions are important when taking Sandimmun Neoral 100mg.
  

  Microemulsion Formulation

  Sandimmun Neoral uses a microemulsion technology that improves the absorption and bioavailability of cyclosporine compared to the original Sandimmun formulation. This allows for more consistent drug levels in the body.

  Convenient Dosing

  The 100mg capsule strength allows for convenient dosing, especially for larger patients or those requiring higher doses. The 50 count bottle provides a 1-2 month supply for most patients.

  Extensive Clinical Experience

  Cyclosporine has been used for over 30 years to prevent organ rejection and treat autoimmune conditions. Sandimmun Neoral specifically has been extensively studied in clinical trials involving thousands of transplant recipients.

  Strict Manufacturing Standards

  As a prescription medication, Sandimmun Neoral must adhere to rigorous manufacturing standards set by regulatory bodies to ensure consistent quality, purity and potency of each batch.

  Comprehensive Patient Support

  Novartis, the manufacturer, provides comprehensive patient support services including financial assistance programs, adherence tools, and educational resources to help patients get the most benefit from their treatment.

  Key Benefits of Sandimmun Neoral 100mg 50’ct

  The key benefits of Sandimmun Neoral 100mg 50’ct include:

  • Prevents organ rejection in transplant patients by suppressing the immune system
  • Treats severe cases of rheumatoid arthritis and psoriasis by reducing inflammation
  • Uses a microemulsion formulation that improves absorption and bioavailability compared to the original Sandimmun
  • Convenient 100mg capsule strength allows for easier dosing, especially for larger patients
  • Extensive clinical experience over 30 years in transplant and autoimmune conditions
  • Adheres to strict manufacturing standards to ensure consistent quality and potency
  • Comprehensive patient support services available from the manufacturer

  Key Ingredient

  The key ingredient in Sandimmun Neoral 100mg is cyclosporine. Cyclosporine is a powerful immunosuppressant that works by blocking the formation of certain immune cells that would normally attack and reject a transplanted organ.                                                                                                 

  Mechanism of Action of Sandimmun Neoral 100mg

  The active ingredient in Sandimmun Neoral 100mg is cyclosporine, which is a powerful immunosuppressant drug.The mechanism of action of cyclosporine is as follows:

  1. Cyclosporine binds to a specific intracellular protein called cyclophilin in T-cells.
  2. This cyclosporine-cyclophilin complex then inhibits the activity of the enzyme calcineurin.
  3. Calcineurin normally activates transcription factors that promote the production of interleukin-2 (IL-2) and other cytokines involved in T-cell activation and proliferation.
  4. By inhibiting calcineurin, cyclosporine blocks the production of these key cytokines, thereby suppressing the activation and proliferation of T-cells.
  5. This reduction in T-cell activity is the primary mechanism by which cyclosporine prevents organ rejection in transplant recipients and reduces inflammation in autoimmune conditions like rheumatoid arthritis and psoriasis.                                                                                                   
     

     Ciclosporin

     Immunosuppressant medication

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     Uses

     Used for rheumatoid arthritis, psoriasis, Crohn’s disease, nephrotic syndrome, eczema, organ transplants to prevent rejection, and as eye drops for dry eyes.

     Administration

     Can be administered orally, intravenously, or as eye drops.

     Drug Class

     Calcineurin inhibitor

     Chemical Structure of Cyclosporine

     The chemical structure of cyclosporine, the active ingredient in Sandimmun Neoral 100mg, is as follows:\ce{C62H111N11O12}Cyclosporine is a cyclic undecapeptide composed of 11 amino acids, some of which are non-standard. The key structural features include:

     • A cyclic peptide ring structure
     • Presence of the unusual amino acid (4R)-4-((E)-2-butenyl-4,N-dimethyl-L-threonine (Bmt)
     • Several N-methylated amino acids
     • Inclusion of the D-alanine residue

     The complex three-dimensional structure of cyclosporine, with its numerous stereocenters, is critical for its immunosuppressive mechanism of action. The cyclic peptide ring and specific amino acid side chains allow cyclosporine to bind to the intracellular protein cyclophilin, which then inhibits the calcineurin signaling pathway in T-cells.This unique chemical structure of cyclosporine, synthesized by the nonribosomal peptide synthetase enzyme, is responsible for the potent and selective immunosuppressive effects that make Sandimmun Neoral an important medication for transplant recipients and patients with severe autoimmune diseases.

     
     

     

     Pharmaceutical Applications of Cyclosporins

     Cyclosporins, particularly cyclosporine (also known as ciclosporin), have several important pharmaceutical applications:

     Organ Transplant Rejection Prevention

     Cyclosporine is widely used to prevent organ rejection in people who have received a kidney, liver, or heart transplant. It works by suppressing the immune system to help the body accept the new organ. Cyclosporine is usually taken along with other immunosuppressant medications.

     Treatment of Autoimmune Diseases

     Cyclosporine is used to treat severe cases of rheumatoid arthritis and plaque psoriasis. In these autoimmune conditions, the body’s immune system attacks healthy tissues. Cyclosporine helps prevent further damage by weakening the immune response.

     Ophthalmic Applications

     Cyclosporine ophthalmic solutions are used to treat dry eye disease (keratoconjunctivitis sicca) by increasing tear production. Cyclosporine emulsions are also approved for treating vernal keratoconjunctivitis in adults and children.

     Other Off-Label Uses

     Cyclosporine is used off-label for a variety of other autoimmune and inflammatory conditions such as atopic dermatitis, blistering disorders, ulcerative colitis, juvenile rheumatoid arthritis, uveitis, connective tissue diseases, and idiopathic thrombocytopenic purpura.The unique chemical structure of cyclosporine, with its cyclic undecapeptide ring and non-standard amino acids, is critical for its potent immunosuppressive effects that make it an important medication for transplant recipients and patients with severe autoimmune diseases. Cyclosporine is synthesized by a nonribosomal peptide synthetase enzyme in fungi like Tolypocladium inflatum

     Dosage

     • The recommended initial oral dose for adult transplant recipients is 15 mg/kg/day divided into two doses every 12 hours.
     • The dose is then gradually reduced over several weeks to a maintenance dose of 5-10 mg/kg/day.
     • For rheumatoid arthritis and psoriasis, the initial dose is 1.25 mg/kg twice daily, which may be increased up to 4 mg/kg/day if needed.
     • Dosage is adjusted based on therapeutic drug monitoring and clinical response.

     Storage

     • Sandimmun Neoral 100mg 50’ct should be stored at room temperature between 15-30°C in a tightly closed container.
     • Avoid exposure to moisture, heat, and direct sunlight.
     • Keep out of reach of children and pets.
     • The shelf life is typically 2-3 years from the manufacturing date when stored properly.

     Reviews:                                                                                                                                    “I’ve been taking Sandimmun Neoral for over 5 years after my kidney transplant. It has helped prevent rejection and keep my immune system in check. The capsules are easy to swallow and the dosing is convenient.” “Sandimmun Neoral has been a game-changer for managing my severe psoriasis. The medication has significantly reduced my symptoms and flare-ups. I’m glad my doctor prescribed this instead of the older Sandimmun formulation.” “The microemulsion formulation of Sandimmun Neoral seems to provide more consistent drug levels compared to the original version. I’ve had good results with this medication in maintaining my transplanted organ.” .