Description

Product Overview

Tegral 200mg is an anticonvulsant medication used to treat epilepsy, bipolar disorder, and trigeminal neuralgia in Pakistan. It contains the active ingredient carbamazepine.

Dosage Information

• The usual adult dosage is 1-2 tablets taken 1-2 times per day, depending on the condition.
• The dose may be started low and gradually increased over a few weeks.
• Children’s dosage is based on their weight.

Side Effects

Common side effects include nausea, vomiting, dizziness, drowsiness, constipation, dry mouth, and unsteadiness. Serious side effects requiring immediate medical attention are rare but may include allergic reactions, liver problems, and low sodium levels.                                                                            Key Benefits of Tegral 200mg Tablets:

1. Epilepsy Treatment: Tegral helps control seizures and manage epilepsy by reducing high-frequency repetitive firing of action potentials in the brain.
2. Trigeminal Neuralgia Management: It alleviates the severe facial pain associated with trigeminal neuralgia by changing how nerves send signals.
3. Mood Stabilization: Tegral helps keep moods steady by adjusting the levels of certain chemicals in the brain, useful in treating bipolar disorder.
4. Off-Label Uses: Occasionally prescribed for mitigating symptoms related to depression and anxiety.

Key Ingredients:

• Carbamazepine: The active ingredient that enhances sodium channel inactivation, reducing high-frequency repetitive firing of action potentials.
• Inactive Ingredients: Colloidal silicon dioxide, croscarmellose sodium, ethylcellulose, glycerin, lactose monohydrate, magnesium stearate, and sodium starch glycolate.

Carbamazepine

Anticonvulsant medication

More

Primary use

Treatment of epilepsy and neuropathic pain, adjunctive treatment in schizophrenia, and as a second-line agent in bipolar disorder

Effectiveness

Comparable to phenytoin and valproate for focal and generalized seizures, but not effective for absence or myoclonic seizures

Discovery

Discovered in 1953 by Swiss chemist Walter Schindler

Key Interactions:

1. MAO Inhibitors: Taking Tegral with MAO inhibitors (e.g. isocarboxazid, linezolid, methylene blue) can cause a serious, potentially fatal drug interaction. Avoid taking MAO inhibitors during Tegral treatment.
2. Azole Antifungals: Certain azole antifungal medications like isavuconazonium and voriconazole can interact with Tegral.
3. Orlistat: The weight loss medication orlistat may interact with Tegral.
4. Macrolide Antibiotics: Macrolide antibiotics like erythromycin can affect the removal of carbamazepine from the body, impacting how Tegral works.
5. Rifamycins: Rifamycin antibiotics like rifabutin can also affect carbamazepine levels.
6. St. John’s Wort: The herbal supplement St. John’s Wort can impact the metabolism of Tegral.
7. Anticoagulants: Tegral can speed up the removal of certain anticoagulant medications like apixaban and rivaroxaban.
8. Other Interactions: Tegral may also interact with calcium channel blockers, HIV medications, and other drugs that are metabolized by the liver.                                                                                      Pregnancy and Breastfeeding:
   • Tegral may cause birth defects if taken during pregnancy, especially in the first trimester. Pregnant women should consult their doctor before using Tegral.
   • Tegral passes into breastmilk, so the effects on nursing infants are unknown. Breastfeeding women should also discuss Tegral use with their doctor.

   Interactions:

   • Tegral can interact with many other medications, including MAO inhibitors, antifungals, antibiotics, anticoagulants, and herbal supplements like St. John’s Wort. Patients should inform their doctor of all other drugs they are taking.
   • Grapefruit juice should be avoided as it can increase the concentration of Tegral in the body.

   Driving and Machinery Use:

   • Tegral can cause drowsiness, dizziness, and unsteadiness, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.

   Monitoring:

   • Patients on long-term Tegral therapy may need periodic blood tests to monitor for potential side effects like decreased bone density.

   Storage:

   • Tegral tablets should be stored at room temperature, away from heat, moisture, and reach of children.

   key dietary precautions to be aware of when taking Tegral 200mg (carbamazepine):         Grapefruit Juice:

   • Patients should avoid consuming grapefruit juice while taking Tegral, as it can increase the concentration of carbamazepine in the body.

   Sugar Intake:

   • Caution is advised if you have diabetes or any other condition that requires you to limit or avoid sugar in your diet. The inactive ingredients in Tegral tablets include lactose monohydrate, which is a form of sugar.

   Hydration:

   • It is recommended to take Tegral with or without food and stay well hydrated while on this medication.

   Avoid Grapefruit Juice

   • The search results indicate that patients should avoid consuming grapefruit juice while taking Tegral, as it can increase the concentration of carbamazepine in the body.

   Dosage Information

   • The usual adult dosage of Tegral 200mg is 1-2 tablets taken 1-2 times per day, depending on the condition being treated.
   • The dose may be started low and gradually increased over a few weeks.
   • Children’s dosage is based on their weight.

   Storage

   • Store Tegral 200mg tablets at room temperature, away from heat, moisture, and direct sunlight.
   • Keep the medication out of reach of children and pets.
   • Do not use Tegral past its expiration date.

   Reviews

   There are no user reviews for Tegral 200mg tablets available in the search results. However, it is a widely used medication for treating epilepsy, bipolar disorder, and trigeminal neuralgia.      Major Interactions:

   • MAO Inhibitors: Taking Tegral with MAO inhibitors (e.g. isocarboxazid, linezolid, methylene blue) can cause a serious, potentially fatal interaction. Avoid using MAO inhibitors during Tegral treatment.
   • Azole Antifungals: Certain azole antifungal medications like isavuconazonium and voriconazole can interact with Tegral.
   • Orlistat: The weight loss drug orlistat may interact with Tegral.

   Moderate Interactions:

   • Macrolide Antibiotics: Macrolide antibiotics like erythromycin can affect the removal of carbamazepine from the body, impacting Tegral’s effectiveness.
   • Rifamycins: Rifamycin antibiotics like rifabutin can also affect carbamazepine levels.
   • St. John’s Wort: The herbal supplement St. John’s Wort can impact the metabolism of Tegral.
   • Anticoagulants: Tegral can speed up the removal of certain anticoagulant medications like apixaban and rivaroxaban.
   • Other Interactions: Tegral may also interact with calcium channel blockers, HIV medications, and other drugs metabolized by the liver.