Description

Ucholine 10mg is a medication containing bethanechol chloride that is used to treat certain bladder problems such as the inability to urinate or completely empty the bladder due to factors like surgery or bladder muscle dysfunction. It works by stimulating contractions of the bladder muscle to improve urination.The typical dosage is 10-50 mg taken orally three to four times daily, with some patients requiring 50-100 mg twice daily. It should be taken on an empty stomach, about 1 hour before or 2 hours after meals, to reduce side effects like nausea and vomiting.Common side effects include dizziness, lightheadedness, nausea, vomiting, abdominal pain, diarrhea, increased saliva/urination, sweating, flushing, watery eyes, and headache. More serious side effects like fainting, fast heartbeat, and severe abdominal pain require prompt medical attention.Ucholine 10mg 100 count tablets are available for purchase online from various Pakistani pharmacies. Prices vary but are generally in the range of 16,000-25,000 Pakistani rupees for a 100 tablet pack.                                                     

Medication Overview

Ucholine 10mg is a medication containing bethanechol chloride that is used to treat certain bladder problems such as the inability to urinate or completely empty the bladder due to factors like surgery or bladder muscle dysfunction. It works by stimulating contractions of the bladder muscle to improve urination.

Dosage and Administration

The typical dosage is 10-50 mg taken orally three to four times daily, with some patients requiring 50-100 mg twice daily. It should be taken on an empty stomach, about 1 hour before or 2 hours after meals, to reduce side effects like nausea and vomiting.

Side Effects

Common side effects include dizziness, lightheadedness, nausea, vomiting, abdominal pain, diarrhea, increased saliva/urination, sweating, flushing, watery eyes, and headache. More serious side effects like fainting, fast heartbeat, and severe abdominal pain require prompt medical attention.

Availability and Pricing

Ucholine 10mg 100 count tablets are available for purchase online from various Pakistani pharmacies. Prices vary but are generally in the range of 16,000-25,000 Pakistani rupees for a 100 tablet pack.          Ucholine 10mg (bethanechol chloride) typically starts working within 30-90 minutes after oral administration, with effects sometimes appearing as quickly as 30 minutes but more often requiring 60-90 minutes to reach maximum effectiveness.                                                                                           

Key Benefits of Ucholine 10mg

Based on the search results, the key benefits of Ucholine 10mg (bethanechol chloride) include:Improves Urination
Ucholine 10mg is used to treat bladder problems that make it difficult to urinate or completely empty the bladder. It works by stimulating contractions of the bladder muscle to improve the ability to urinate.Treats Urinary Retention
Ucholine is often prescribed for individuals who experience difficulty urinating or have incomplete bladder emptying due to factors like surgery or bladder muscle dysfunction.Rapid Onset of Action
Ucholine typically starts working within 30-90 minutes after oral administration, with effects sometimes appearing as quickly as 30 minutes.

Key Ingredient

The key active ingredient in Ucholine 10mg is bethanechol chloride. Bethanechol chloride is a cholinergic agent that stimulates muscarinic receptors, leading to contraction of the bladder muscle to improve urination.                                                                                                                                         

Mechanism of Action

Ucholine 10mg contains the active ingredient bethanechol chloride, which is a cholinergic agent that stimulates muscarinic receptors. Its mechanism of action is as follows:

• Bethanechol chloride binds to and activates muscarinic acetylcholine receptors, particularly M2 and M3 receptors, in the bladder muscle.
• Activation of these receptors leads to increased intracellular calcium levels, which triggers contraction of the detrusor muscle of the bladder.
• The contractions of the bladder muscle improve the ability to urinate and completely empty the bladder in patients with urinary retention or incomplete bladder emptying.
• Bethanechol also stimulates muscarinic receptors in the gastrointestinal tract, which can lead to increased gastrointestinal motility and secretions.                                                                               
  

  Chemical Structure of Bethanechol

  The chemical structure of bethanechol chloride, the active ingredient in Ucholine 10mg, is as follows:

  \ce{C7H17ClN2O2}

  Bethanechol chloride has the IUPAC name “2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-1-propanaminium chloride”. Its molecular formula is C7H17ClN2O2 and it has a molar mass of 196.67 g/mol.The key structural features of bethanechol chloride are:

  • A quaternary ammonium group with three methyl substituents
  • A carbamate functional group
  • A propyl chain connecting the quaternary ammonium and carbamate groups
  • A chloride counterion

  This chemical structure allows bethanechol to selectively bind to and activate muscarinic acetylcholine receptors, particularly the M2 and M3 subtypes, leading to the desired effects on the bladder and gastrointestinal tract.                                                                                                                               

  Dosage

  The typical dosage of Ucholine 10mg (bethanechol chloride) is:

  • 10-50 mg taken orally three to four times daily
  • Some patients may require 50-100 mg twice daily
  • It should be taken on an empty stomach, about 1 hour before or 2 hours after meals, to reduce side effects like nausea and vomiting

  The effects of Ucholine typically appear within 30 minutes and are usually maximal within 60 to 90 minutes. The drug effects persist for about one hour.

  Storage

  Ucholine 10mg tablets should be stored at 20° to 25°C (68° to 77°F) in a tight, light-resistant container as defined in the USP, with a child-resistant closure.

  Reviews

  The search results do not contain any direct reviews of Ucholine 10mg. However, bethanechol chloride, the active ingredient, is generally well-tolerated with common side effects including dizziness, lightheadedness, nausea, vomiting, abdominal pain, diarrhea, increased saliva/urination, sweating, flushing, watery eyes, and headache.More serious side effects like fainting, fast heartbeat, and severe abdominal pain require prompt medical attention. Patients should consult their healthcare provider about the benefits and risks of using Ucholine 10mg.  

Precautions for Using Ucholine

Allergies
Tell your doctor or pharmacist if you are allergic to bethanechol or any other ingredients in Ucholine.Medical History
Inform your doctor about your medical history, especially conditions like:

• Recent stomach/intestinal/bladder surgery
• Stomach/intestinal problems (e.g. ulcers, blockage, spasms)
• Peritonitis
• Bladder blockage
• Nerve problems (vagotonia)
• Overactive thyroid
• Lung diseases (e.g. asthma, COPD)
• Heart problems (e.g. coronary artery disease, slow heartbeat)
• Seizures
• Parkinson’s disease
• Blood pressure issues

Dizziness and Drowsiness
Ucholine may cause dizziness or drowsiness. Avoid driving, using machinery, or doing other tasks requiring alertness until you know how the medication affects you. Limit alcohol use as it can increase these effects                                                                                                                                        .Pregnancy and Breastfeeding
Ucholine should only be used during pregnancy when clearly needed. Consult your doctor about the risks and benefits. It is unknown if the drug passes into breast milk, so discuss with your doctor before breastfeeding.                                                                                                                                        Drug Interactions
Certain medications like anticholinergics, sedatives, and some antidepressants can interact with Ucholine. Provide your doctor with a full list of your medications.                                                      Overdose
Symptoms of overdose include abdominal pain, flushing, increased saliva, sweating, nausea, and vomiting. Seek immediate medical attention if an overdose occurs.