Description

Zyprexa 10mg tablets are a prescription-only medication imported into the country. The search results indicate that Zyprexa 10mg tablets are available in 28-tablet packs from various pharmaceutical companies, including CST Pharma Ltd and Doncaster Pharmaceuticals Ltd. These imported Zyprexa tablets are classified as parallel imports, meaning they are authorized for sale in the country despite not being directly supplied by the original manufacturer, Eli Lilly.

Product Overview

• Zyprexa (olanzapine) is an antipsychotic medication used to treat schizophrenia and bipolar disorder.
• This is a 28-tablet pack of the 10mg strength Zyprexa tablets, imported into the country.
• Zyprexa is manufactured by Eli Lilly, but this pack is a parallel import, not directly supplied by the original manufacturer.

Parallel Import Details

• Parallel imports are authorized for sale despite not being directly supplied by the original manufacturer.
• The Zyprexa 10mg 28-tablet pack is imported by pharmaceutical companies such as CST Pharma Ltd and Doncaster Pharmaceuticals Ltd.
• Parallel imports allow for increased competition and potentially lower prices for consumers, while still maintaining quality standards.

Prescription Requirements

• Zyprexa is a prescription-only medication and requires a valid prescription from a licensed healthcare provider.
• Patients should consult their doctor before using Zyprexa or any other antipsychotic medication.
• Proper dosage and administration instructions should be followed carefully.

key dietary considerations when taking Zyprexa (olanzapine)                                                                  Alcohol Interactions
The search results indicate that you should avoid or limit the use of alcohol while taking Zyprexa, as alcohol can make the drowsiness and dizziness side effects of Zyprexa worse.Caffeine Interactions
The search results mention that caffeine-rich beverages should be avoided when taking Zyprexa, as caffeine can interact with the medication.Healthier Fats Recommended
The search results suggest opting for healthier fats, such as those found in avocados or nuts, rather than less healthy fats when taking Zyprexa.No Specific Food Restrictions
The search results do not mention any specific food restrictions or requirements when taking Zyprexa. The medication can generally be taken with or without food.

Olanzapine

Atypical antipsychotic medication

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Primary uses

Treatment of schizophrenia and bipolar disorder

Administration

By mouth or intramuscular injection

Common side effects

Weight gain, movement disorders, dizziness, feeling tired, constipation, dry mouth

Chemical Structure of Olanzapine (Zyprexa)

The chemical structure of olanzapine, the active ingredient in Zyprexa, is as follows:\ce{C17H20N4S}Key points about the chemical structure:

1. Molecular Formula: The molecular formula of olanzapine is C17H20N4S, indicating it contains 17 carbon atoms, 20 hydrogen atoms, 4 nitrogen atoms, and 1 sulfur atom.
2. Molecular Weight: The molecular weight of olanzapine is 312.44 g/mol.
3. IUPAC Name: The IUPAC name is 5-methyl-8-(4-methylpiperazin-1-yl)-4-thia-2,9-diazatricyclo[8.4.0.0^{3,7}]tetradeca-1(14),3(7),5,8,10,12-hexaene.
4. Chemical Structure: Olanzapine is a heterocyclic compound containing a thienobenzodiazepine core structure. It has a methyl group attached to the 5-position and a 4-methylpiperazine moiety attached to the 8-position.
5. Stereochemistry: Olanzapine has a single stereocenter at the 3-position, but it is typically administered as a racemic mixture.
6. Solubility: Olanzapine is a weakly basic compound with low aqueous solubility. It is more soluble in organic solvents.

Dosage Information

Olanzapine is available in various strengths and forms, including tablets, orally disintegrating tablets, and intramuscular injections. The dosage varies depending on the condition being treated and the patient’s age.

Usual Adult Dose for Bipolar Disorder

• Monotherapy: Initial dose: 10 or 15 mg orally once a day; maintenance dose: 5 to 20 mg orally once a day; maximum dose: 20 mg/day.
• Adjunctive Treatment with Lithium or Valproate: Initial dose: 10 mg orally once a day; maintenance dose: 5 to 20 mg orally once a day; maximum dose: 20 mg/day.
• Treatment of Depressive Episodes with Fluoxetine: Initial dose: 5 mg orally once a day (with fluoxetine); maximum dose: 18 mg/day (with fluoxetine).

Usual Adult Dose for Schizophrenia

• Oral: Initial dose: 5 to 10 mg orally once a day; target dose: 10 mg orally once a day; maximum dose: 20 mg orally once a day.
• Parenteral: Initial dose: 210 mg IM every 2 weeks or 405 mg IM every 4 weeks; maintenance dose: 150 mg IM every 2 weeks or 300 mg IM every 4 weeks.

Usual Geriatric Dose for Agitated State

• Immediate-release Injection: Initial dose: 5 mg IM once; subsequent doses may be given for agitation that persists; maximum dose: 10 mg IM 2 to 4 hours apart.

Storage Requirements

• Tablets and Oral Disintegrating Tablets: Store at room temperature between 68°F and 77°F (20°C and 25°C), away from heat, moisture, and direct light.
• Immediate-release Injection: Store at room temperature between 68°F and 77°F (20°C and 25°C), away from heat, moisture, and direct light.

Reviews and Additional Information

• Healthline: Olanzapine is used to treat schizophrenia, bipolar disorder, and depression. It is available in various strengths and forms, including tablets and orally disintegrating tablets. The dosage varies depending on the condition and patient age.
• Mayo Clinic: Store olanzapine at room temperature, away from heat, moisture, and direct light. Do not double doses. The dosage for bipolar depression is typically 5 mg olanzapine and 20 mg fluoxetine, taken once a day in the evening.
• Medscape: Olanzapine is used to treat depression, bipolar disorder, and chemotherapy-induced nausea and vomiting. The dosage varies depending on the condition and patient age. It is important to use caution and adjust the dosage as needed.

Key Points

• Dosage Adjustments: Dosage adjustments should be made at intervals of at least 24 hours in 5 mg increments/decrements.
• Maximum Doses: The maximum dose for bipolar disorder is 20 mg/day, and for schizophrenia, it is 20 mg orally once a day.
• Storage: Store olanzapine at room temperature, away from heat, moisture, and direct light.
• Reviews: Olanzapine is used to treat various conditions and is available in various strengths and forms. The dosage varies depending on the condition and patient age. It is important to use caution and adjust the dosage as needed.

Summary

Olanzapine is a medication used to treat schizophrenia, bipolar disorder, and depression. The dosage varies depending on the condition and patient age. It is available in various strengths and forms, including tablets, orally disintegrating tablets, and intramuscular injections. The storage requirements include storing at room temperature, away from heat, moisture, and direct light. Dosage adjustments should be made at intervals of at least 24 hours in 5 mg increments/decrements. The maximum dose for bipolar disorder is 20 mg/day, and for schizophrenia, it is 20 mg orally once a day. Reviews highlight the importance of using caution and adjusting the dosage as needed.

Proper Administration Technique

• Olanzapine injection is for intramuscular use only and should never be administered intravenously or subcutaneously.
• Inject slowly, deep into the muscle mass.

Reconstitution and Storage

• Olanzapine injection should be reconstituted only with Sterile Water for Injection.
• The reconstituted solution should be used immediately, within 1 hour, and any unused portion should be discarded.
• Reconstituted olanzapine injection may be stored at room temperature for up to 1 hour if necessary.

Potential Interactions

• Olanzapine injection should not be combined in a syringe with diazepam injection, lorazepam injection, or haloperidol injection, as these combinations can cause precipitation or pH changes that degrade olanzapine.

Monitoring for Side Effects

• Patients should be closely monitored for signs of post-injection delirium/sedation syndrome, such as dizziness, drowsiness, sleepiness, seizures, or confusion.
• Healthcare providers should watch for signs of neuroleptic malignant syndrome, including fever, muscle stiffness, and autonomic instability.

Special Populations

• Olanzapine injection should not be used to treat behavioral problems in older adults with dementia or Alzheimer’s disease.
• Dosage adjustments may be needed in elderly patients due to age-related health conditions.