Description

Epanutin 100mg capsules are used to treat epilepsy and control seizures. Each capsule contains 100mg of the active ingredient phenytoin sodium.The other ingredients are:

• Lactose monohydrate
• Magnesium stearate
• Sodium dodecyl sulphate
• Gelatin capsule shells containing erythrosine (E127), quinoline yellow (E104), and titanium dioxide (E171) as coloring agents
• Printing ink containing shellac, black iron oxide (E172) and propylene glycol

Epanutin 100mg capsules are available in packs of 84 or 100 capsules. They are half white and half orange hard capsules marked with ‘EPANUTIN 100’. The capsules are packed in a plastic container with a desiccant, which is packaged in an outer carton.Epanutin can also be used to treat trigeminal neuralgia (facial nerve pain). It is available over-the-counter and can be chewed or dissolved in water.                                                                                         

Mechanism of Action

Epanutin (phenytoin) is an anticonvulsant medication that works by stabilizing the neuronal membrane and reducing the spread of seizure activity in the brain. It does this by blocking sodium channels and inhibiting the release of excitatory neurotransmitters.

Pharmacokinetics

• Phenytoin is well absorbed from the gastrointestinal tract, with peak plasma levels occurring 3-12 hours after oral administration.
• It has a long half-life of 22 hours, allowing for once-daily dosing.
• Phenytoin is highly protein bound (90%) and undergoes extensive hepatic metabolism.

Therapeutic Uses

In addition to treating epilepsy, Epanutin is also used for:

• Trigeminal neuralgia – a type of facial nerve pain
• Cardiac arrhythmias – to prevent and control irregular heart rhythms
• Neuropathic pain – to treat nerve-related pain conditions

Dosing and Administration

• Epanutin 100mg capsules are typically taken 1-3 times daily, with or without food.
• The dosage is individualized based on the patient’s response and blood levels of phenytoin.
• Therapeutic blood levels are typically between 10-20 mcg/mL.

Unique Features

• Epanutin capsules can be chewed or dissolved in water for patients who have difficulty swallowing.
• The capsules contain a desiccant to maintain the stability and integrity of the medication.
• Epanutin has a narrow therapeutic index, meaning small changes in dosage can significantly impact efficacy and side effects.                                                                                                Mechanism of action                                                                                                                  Epanutin (phenytoin) 100mg capsules work by stabilizing the neuronal membrane and reducing the spread of seizure activity in the brain. Specifically:Epanutin blocks sodium channels and inhibits the release of excitatory neurotransmitters. This prevents the rapid and excessive firing of neurons that leads to seizures.Phenytoin, the active ingredient in Epanutin, is an anticonvulsant medication that is effective in controlling a variety of epileptic conditions. It is one of a group of medicines called anti-epileptic drugs that are used to treat epilepsy.By stabilizing the neuronal membrane and limiting the propagation of seizure activity, Epanutin 100mg capsules help control and prevent seizures in epilepsy patients.chemical structure of Epanutin (phenytoin sodium):The molecular formula of phenytoin sodium is C15H11N2NaO2. The chemical structure can be represented as:
  c1ccc(cc1)C2(C(=O)[N-]C(=O)N2)c3ccccc3.[Na+]


  This shows that phenytoin sodium consists of a diphenylhydantoin moiety with a sodium counterion. The key structural features are:

  • Two phenyl rings attached to a 5-membered imidazolone ring
  • A sodium cation bonded to the deprotonated oxygen atom

  The IUPAC name for this compound is “sodium 2-hydroxy-4,4-diphenyl-4H-imidazol-5-olate”.The InChI key, which provides a unique identifier for the chemical structure, is FJPYVLNWWICYDW-UHFFFAOYSA-M.

  Key Benefits

  • Used to control a variety of epileptic conditions and prevent seizures
  • Can be used to treat trigeminal neuralgia (facial nerve pain)
  • Helps control or prevent seizures during or after brain surgery or severe head injury

  Key Ingredients

  The active ingredient in Epanutin 100mg capsules is phenytoin sodium. Each capsule contains 100mg of phenytoin sodium.The other ingredients are:

  • Lactose monohydrate
  • Magnesium stearate
  • Sodium dodecyl sulphate
  • Gelatin capsule shells containing erythrosine (E127), quinoline yellow (E104), and titanium dioxide (E171) as coloring agents
  • Printing ink containing shellac, black iron oxide (E172) and propylene glycol
    

    Dosage

    The recommended dosage for Epanutin 100mg capsules is:Adults:

    • Most adults need between 200mg and 500mg per day, either as a single or divided dose. Occasionally higher doses are needed.

    Children and Adolescents:

    • Infants and children usually start on a dose of 5mg per kg of body weight per day, given in two divided doses. The dose is then adjusted up to a maximum of 300mg per day.

    Elderly:

    • Due to decreased clearance of phenytoin, lower or less frequent dosing may be needed for elderly patients. The dose should be carefully considered and adjusted by the doctor.

    Storage

    Epanutin 100mg capsules should be stored:

    • Below 25°C
    • In the original package to protect from light
    • Keep out of the sight and reach of children

    Do not use this medicine after the expiry date printed on the carton and bottle labels.

    Reviews

    The search results do not contain any specific reviews or feedback about Epanutin 100mg capsules. The information provided focuses on the dosage, administration, and storage requirements for this medication.Without access to customer or patient reviews, I cannot comment on the overall satisfaction or experiences people have had with Epanutin 100mg capsules. The available information is limited to the technical details about the product.

    

    Phenytoin

    Anti-seizure medication

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    Primary Use

    Prevents tonic-clonic (grand mal) and focal seizures, treats status epilepticus, certain heart arrhythmias, and neuropathic pain

    Administration

    Can be taken intravenously or by mouth; intravenous form begins working within 30 minutes

    Common Side Effects

    Include nausea, stomach pain, loss of appetite, poor coordination, increased hair growth, and enlargement of the gums