Description

Jardiance 10mg Tablet is a medication used to control high blood sugar levels in adults with type 2 diabetes. The active ingredient is empagliflozin, which belongs to a class of drugs called SGLT2 inhibitors that work by helping the kidneys remove excess glucose from the body.Some key points about Jardiance 10mg Tablet:

• It can be taken with or without food, but should be taken at the same time each day. The dosage is determined by your doctor.
• It helps lower HbA1c (average blood sugar) levels and can also lead to modest weight loss.
• Common side effects include increased urination, dehydration, genital yeast infections, and low blood sugar (when used with other diabetes medications).
• It should be used with caution in patients with kidney disease, as the dosage may need to be adjusted.
• Jardiance is part of a comprehensive treatment plan that also includes diet, exercise, and other diabetes medications as prescribed by your doctor.
  

  Mechanism of Action

  Jardiance (empagliflozin) is a unique medication in that it works by inhibiting the sodium-glucose co-transporter 2 (SGLT2) in the kidneys. This causes increased excretion of glucose in the urine, leading to reduced blood sugar levels.

  Cardiovascular Benefits

  In clinical trials, Jardiance has been shown to reduce the risk of cardiovascular death in patients with type 2 diabetes and established cardiovascular disease. This is a unique benefit not seen with all diabetes medications.

  Weight Loss Effects

  In addition to lowering blood sugar, Jardiance can also lead to modest weight loss of 2-3 kg on average. This is thought to be due to the calorie loss from the increased urinary glucose excretion.

  Dosing Flexibility

  Jardiance is available in 10mg and 25mg tablet strengths, allowing for flexible dosing to be tailored to the individual patient’s needs and response to treatment.

  Renal Safety

  Jardiance has demonstrated a favorable renal safety profile, with studies showing it can slow the progression of kidney disease in patients with type 2 diabetes.

  Key Benefits of Jardiance 10mg Tablet

  1. Lowers blood sugar levels in adults with type 2 diabetes 
  2. Can reduce the risk of cardiovascular death in patients with type 2 diabetes and established cardiovascular disease 
  3. May lead to modest weight loss of 2-3 kg on average 
  4. Has a favorable renal (kidney) safety profile and can slow the progression of kidney disease 
  5. Provides dosing flexibility with 10mg and 25mg tablet strengths 

  Key Ingredients

  The active ingredient in Jardiance 10mg Tablet is empagliflozin, which belongs to a class of drugs called sodium-glucose co-transporter 2 (SGLT2) inhibitors .Empagliflozin works by inhibiting SGLT2 in the kidneys, which reduces the reabsorption of filtered glucose and increases the excretion of glucose in the urine. This in turn lowers blood glucose levels.The 10mg tablet also contains the following inactive ingredients:

  • Lactose monohydrate
  • Microcrystalline cellulose
  • Croscarmellose sodium
  • Magnesium stearate
  • Hypromellose
  • Titanium dioxide
  • Talc
  • Iron oxide yellow                                                                                                                              key details about the mechanism of action of Jardiance (empagliflozin) 10mg Tablet:The active ingredient in Jardiance 10mg is empagliflozin, which is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. Empagliflozin works by inhibiting SGLT2 in the kidneys. SGLT2 is responsible for reabsorbing the majority of filtered glucose from the tubules back into the bloodstream. By inhibiting SGLT2, empagliflozin reduces the reabsorption of filtered glucose and increases the excretion of glucose in the urine. This in turn lowers blood glucose levels in patients with type 2 diabetes. This unique mechanism of action, targeting the kidneys to increase urinary glucose excretion, is what differentiates SGLT2 inhibitors like Jardiance from other diabetes medications that work through different pathways. In summary, the key mechanism of action of Jardiance 10mg is inhibition of the SGLT2 transporter in the kidneys, leading to reduced glucose reabsorption and increased urinary glucose excretion, which helps lower blood sugar levels in adults with type 2 diabetes.
  Empagliflozin

  Antidiabetic Medication

  More

  Trade Names

  Jardiance, others

  Use

  Improves glucose control in type 2 diabetes

  Side Effects

  Include hyperventilation, abdominal pain, yeast infections

  According to the search results, the chemical structure of empagliflozin, the active ingredient in Jardiance 10mg Tablet, is:

  O OH O H OH O H O Cl O


  The chemical name of empagliflozin is D-Glucitol,1,5-anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-, (1S).Its molecular formula is C23H27ClO7 and the molecular weight is 450.91.Empagliflozin is a white to yellowish, non-hygroscopic powder that is very slightly soluble in water

  Dosage

  • The recommended starting dose of Jardiance 10mg is one tablet taken once daily in the morning, with or without food.
  • The dose may be increased to 25mg once daily if needed and tolerated for better glycemic control.
  • The maximum recommended dose is 25mg per day.
  • Jardiance should not be used to treat type 1 diabetes or diabetic ketoacidosis.
  • Dosage adjustments may be needed for patients with renal impairment.

  Storage

  • Jardiance 10mg tablets should be stored at room temperature, below 30°C.
  • Keep the medication in the original container and protect it from light and moisture.
  • Store Jardiance out of the reach of children and pets.
  • Do not use Jardiance after the expiration date printed on the package.

  Reviews

  Based on patient reviews:

  • Jardiance has been effective in lowering blood sugar levels for many patients with type 2 diabetes.
  • Some patients report experiencing side effects like increased urination, genital yeast infections, and low blood sugar, especially when first starting the medication.
  • Many patients appreciate the once-daily dosing and the potential cardiovascular benefits of Jardiance.
  • Overall, Jardiance seems to be well-tolerated by most patients when taken as directed and as part of a comprehensive diabetes management plan.
  • Patients are advised to closely monitor their blood sugar, stay hydrated, and report any concerning side effects to their healthcare provider.