Description

Panadol Plain Tab 24’s is a paracetamol-based medication imported from Turkey that provides effective relief from fever and mild to moderate pain. Each tablet contains 500mg of paracetamol as the active ingredient.Panadol can be used to treat various types of pain, including:

• Headache/tension headache
• Toothache
• Migraine headache
• Musculoskeletal pain
• Osteoarthritis
• Backache

The recommended dosage for adults and children 12 years and over is 1-2 tablets every 4 to 6 hours as needed, not exceeding 8 tablets (4000mg paracetamol) in 24 hours. Panadol should not be taken more frequently than every 4 hours and the lowest effective dose should be used.Panadol is available in tablet format and is suitable for elderly people. It is unlikely to cause stomach irritation when used as directed and can be taken on an empty stomach.Panadol should not be used with other paracetamol-containing products, as an overdose may cause liver failure which can lead to liver transplant or death

Active Ingredient

• Each tablet contains 500mg of paracetamol

Indications

• Effective relief from fever and mild to moderate pain
• Can be used to treat:
  • Headache/tension headache
  • Toothache
  • Migraine headache
  • Musculoskeletal pain
  • Osteoarthritis
  • Backache

Dosage

• Recommended dose for adults and children 12 years and over:
  • 1-2 tablets every 4 to 6 hours as needed
  • Not to exceed 8 tablets (4000mg paracetamol) in 24 hours
• Lowest effective dose should be used
• Should not be taken more frequently than every 4 hours

Unique Features

• Unlikely to cause stomach irritation when used as directed
• Can be taken on an empty stomach
• Suitable for elderly people

Cautions

• Should not be used with other paracetamol-containing products to avoid overdose
• Underlying liver disease increases the risk of paracetamol-related liver damage

. Underlying liver disease increases the risk of paracetamol-related liver damage.                               

Key Benefits of Panadol Plain Tab 24’s Imported from Turkey

Effective Pain and Fever Relief

• Provides temporary, effective relief from a variety of pain conditions including headaches, toothache, muscle aches, arthritis, and period pain
• Also helps reduce fever

Gentle on the Stomach

• Unlikely to cause stomach irritation when used as directed
• Can be taken on an empty stomach

Suitable for Elderly

• The tablet format makes it suitable for elderly people to take

Key Ingredients

• Each tablet contains 500mg of paracetamol as the active ingredient

Mechanism of Action of Panadol Plain Tab 24’s

The active ingredient in Panadol Plain Tab 24’s is paracetamol (acetaminophen), which has the following mechanisms of action:Pain Relief and Fever Reduction

• Paracetamol exerts its analgesic (pain-relieving) and antipyretic (fever-reducing) effects primarily by inhibiting the synthesis of prostaglandins in the central nervous system.
• Prostaglandins are involved in the transmission of pain signals and the regulation of body temperature.

Anti-inflammatory Effects

• Paracetamol also has weak anti-inflammatory properties, likely through inhibition of the cyclooxygenase (COX) enzymes, though to a lesser degree than non-steroidal anti-inflammatory drugs (NSAIDs).

Modulation of Endocannabinoid System

• Paracetamol is metabolized to an active metabolite called AM404, which can indirectly enhance the activity of the endocannabinoid system by inhibiting the reuptake and degradation of endogenous cannabinoids like anandamide.
• This modulation of the endocannabinoid system contributes to paracetamol’s analgesic and antipyretic effects.

Paracetamol

Non-opioid analgesic and antipyretic agent

More

Primary Use

Used to treat fever and mild to moderate pain

Trade Names

Tylenol, Panadol, among others

Effectiveness

Slightly decreases body temperature, provides pain relief in certain conditions like acute mild migraines and post-surgical pain but is deemed inferior to ibuprofen in several aspects