Description

CinnaTropin Overview

CinnaTropin is a brand of recombinant human growth hormone (somatropin) produced by CinnaGen. It is primarily used for:

• Pediatric Growth Disorders: Treatment of growth failure due to inadequate secretion of endogenous growth hormone.
• Performance Enhancement: Popular among athletes for muscle and bone growth.

Product Details

• Formulation: 10 mg of somatropin in a 1.5 ml solution.
• Administration: Subcutaneous injection.

Availability in Pakistan

• Price: Approximately PKR 9,500.
• Purchase: Available through pharmacies and online platforms, but ensure to buy from reputable sources to guarantee authenticity.

Usage Instructions

• Storage:
  • Keep in a refrigerator between 2°C and 8°C.
  • Do not freeze.
  • Once opened, can be stored at room temperature for a limited time (follow specific guidelines).

Potential Side Effects

Common side effects may include:

• Edema: Swelling due to fluid retention.
• Headache: Can occur in some users.
• Hypothyroidism: Monitor thyroid function.
• Injection Site Reactions: Redness, swelling, or pain at the injection site.

Consultation and Precautions

• Medical Advice: Always consult a healthcare provider before starting treatment, especially if taking other medications to avoid interactions.
• Monitoring: Regular check-ups are recommended to monitor growth and any side effects.
  

  Key Benefits of CinnaTropin

  CinnaTropin, containing somatropin, offers several key benefits:

  • Growth Promotion: It significantly aids in the growth of bones and muscles, making it essential for individuals with growth hormone deficiencies, particularly in pediatric patients.
  • Metabolic Enhancement: Somatropin plays a crucial role in metabolism, helping to improve fat metabolism and increase lean muscle mass.
  • Improved Immune Function: It has been noted to strengthen the immune system, contributing to overall health.
  • Performance Enhancement: Athletes and fitness enthusiasts often use it to enhance physical performance, build muscle, and reduce body fat.
  • Treatment for Specific Conditions: CinnaTropin is indicated for conditions such as Turner syndrome, chronic renal insufficiency, and short stature in children who have not shown catch-up growth by age four.

  Key Ingredients

  The primary ingredient in CinnaTropin is:

  • Somatropin: A recombinant human growth hormone that mimics the natural growth hormone produced by the pituitary gland. Each pre-filled pen of CinnaTropin contains either 5 mg or 10 mg of somatropin in a 1.5 ml solution, designed for subcutaneous injection.

  Mechanism of Action

  The active ingredient in CinnaTropin is somatropin, a recombinant human growth hormone. Somatropin exerts its effects through the following mechanism of action:

  • Binding to Growth Hormone Receptors: Somatropin binds to dimeric growth hormone receptors located on the cell membranes of target tissues, such as the liver and cartilage.
  • Intracellular Signal Transduction: The binding of somatropin to its receptor triggers intracellular signal transduction, leading to the induction of transcription and translation of growth hormone-dependent proteins, including:
    • Insulin-like Growth Factor-1 (IGF-1)
    • IGF Binding Protein-3 (IGFBP-3)
    • Acid-Labile Subunit (ALS)
  • Direct and Indirect Effects: Somatropin has both direct tissue and metabolic effects, as well as effects mediated indirectly by IGF-1. These include:
    • Stimulation of chondrocyte differentiation and proliferation
    • Stimulation of hepatic glucose output
    • Promotion of protein synthesis
    • Lipolysis (breakdown of fats)
  • Stimulation of Skeletal Growth: In pediatric patients with growth hormone deficiency (GHD), somatropin stimulates skeletal growth by acting on the growth plates (epiphyses) of long bones, increasing linear growth rate (height velocity).
  • Increased Cellular Protein Synthesis: The stimulation of skeletal growth by somatropin is facilitated in part by increased cellular protein synthesis, which facilitates linear growth.
  

  Chemical Structure of CinnaTropin (Somatropin)

  CinnaTropin contains somatropin, a recombinant form of human growth hormone. The chemical structure of somatropin can be described as follows:

  • Molecular Formula: C₃₉H₆₀N₈O₁₃S
  • Molecular Weight: Approximately somatropin has a molecular weight of around 22,124 Da.

  Structural Characteristics

  Somatropin is a peptide hormone consisting of 191 amino acids. The structure is characterized by:

  • Peptide Chain: A linear sequence of amino acids linked by peptide bonds.
  • Disulfide Bridges: The presence of disulfide bonds between cysteine residues that stabilize the three-dimensional structure.
  • Biological Activity: The specific sequence of amino acids is crucial for its biological activity, influencing how it interacts with growth hormone receptors.

  Visual Representation

  While I cannot provide images directly, the chemical structure can often be visualized in molecular modeling software or databases like PubChem, which show the arrangement of atoms and bonds in somatropin.

  
  Key Precautions for CinnaTropin

  When using CinnaTropin (somatropin), it is essential to consider the following precautions:

  • Contraindications: CinnaTropin should not be used in individuals with:
    • Closed epiphyses (in pediatric patients).
    • Acute critical illness due to complications from surgery, trauma, or respiratory failure.
    • Active malignancies or severe nonproliferative diabetic retinopathy.
  • Medical History: Inform your healthcare provider about your medical history, especially if you have:
    • A history of cancer.
    • Diabetes or insulin resistance.
    • Hypothyroidism or other endocrine disorders.
  • Pregnancy and Breastfeeding: Discuss with your healthcare provider if you are pregnant, plan to become pregnant, or are breastfeeding, as the safety of somatropin during these periods is not fully established.
  • Drug Interactions: Notify your healthcare provider about all medications you are taking, including over-the-counter drugs, vitamins, and herbal products, as they may interact with somatropin.
  • Monitoring: Regular monitoring of growth, thyroid function, and blood glucose levels is recommended during treatment.

  Dietary Restrictions

  While there are no specific dietary restrictions directly associated with CinnaTropin, the following general guidelines may be beneficial:

  • Balanced Diet: A diet rich in proteins, healthy fats, and carbohydrates can support the anabolic effects of somatropin. Adequate protein intake is particularly important for muscle growth.
  • Caloric Intake: If using CinnaTropin for weight management or obesity treatment, a hypocaloric diet may be recommended to enhance fat loss while preserving lean body mass.
  • Avoid Alcohol: Limiting alcohol consumption is advisable, as it may interfere with hormone metabolism and overall health.
  • Hydration: Ensure proper hydration, as adequate fluid intake is crucial for metabolic processes.

  Drug Interactions

  CinnaTropin has a significant number of known drug interactions:

  • Total Interactions: 432 drugs are known to interact with somatropin, categorized as follows:
    • Major Interactions: 3
    • Moderate Interactions: 415
    • Minor Interactions: 14

  Commonly Checked Interactions

  Some frequently checked medications that may interact with CinnaTropin include:

  • Acetylsalicylic Acid (aspirin)
  • Adderall (amphetamine/dextroamphetamine)
  • Aromasin (exemestane)
  • Cortef (hydrocortisone)
  • Lexapro (escitalopram)
  • Lipitor (atorvastatin)
  • Synthroid (levothyroxine)

  These medications can have varying degrees of interaction, ranging from minor effects to significant risks.

  Specific Interaction Effects

  • Hypoglycemic Agents: Somatropin may decrease the effectiveness of certain hypoglycemic medications, such as acarbose and acetohexamide, leading to increased blood sugar levels.
  • Corticosteroids: The concurrent use of corticosteroids (like hydrocortisone) can inhibit the growth-promoting effects of somatropin.
  • Anticoagulants: Somatropin may affect the metabolism of anticoagulants, such as acenocoumarol, potentially increasing bleeding risk.

  Food and Alcohol Interactions

  • Alcohol: There is one known alcohol interaction with somatropin. Alcohol consumption should be monitored as it may affect hormone metabolism.

  Disease Interactions

  CinnaTropin also has interactions with certain diseases, including:

  • Diabetes: Patients with diabetes should be closely monitored, as somatropin can affect glucose metabolism.
  • Hypothyroidism: Thyroid function should be assessed, as somatropin can influence thyroid hormone levels.
  • Active Malignancy: CinnaTropin is contraindicated in patients with active malignancies.

  Medications to Avoid

  1. Corticosteroids (e.g., prednisone, dexamethasone):
     • These can inhibit the growth-promoting effects of somatropin.
  2. Insulin and Oral Diabetes Medications:
     • Somatropin can affect glucose metabolism, potentially reducing the effectiveness of diabetes medications.
  3. Anticoagulants (e.g., warfarin):
     • Somatropin may alter the metabolism of anticoagulants, increasing the risk of bleeding.
  4. Hormonal Treatments (e.g., birth control pills, hormone replacement therapy):
     • These may interact with somatropin, affecting hormone levels and overall treatment outcomes.
  5. Medications for Diabetic Retinopathy:
     • Patients with diabetic retinopathy should avoid somatropin due to the risk of worsening eye conditions.
  6. Drugs Affecting Thyroid Function:
     • Patients on thyroid medications should be monitored as somatropin can influence thyroid hormone levels.

  Conditions to Consider

  In addition to specific medications, individuals with the following conditions should avoid using CinnaTropin:

  • Active Malignancy: Use is contraindicated in patients with active cancer.
  • Acute Critical Illness: Avoid in cases of severe illness due to complications from surgery, trauma, or respiratory failure.
  • Closed Epiphyses: Somatropin should not be used in pediatric patients with closed growth plates.
  • Prader-Willi Syndrome: Particularly if the patient is overweight or has severe breathing problems.

  Alcohol and Food Interactions

  • Alcohol: It is advisable to limit alcohol consumption while taking somatropin, as it may interfere with hormone metabolism and lead to adverse effects.

  Use During Pregnancy

  • Safety: CinnaTropin is not recommended for women who are pregnant or planning to become pregnant. There is insufficient evidence regarding its safety during pregnancy, and potential risks to the fetus have not been fully established.
  • Action Required: If a patient becomes pregnant while using CinnaTropin, it is advised to stop the treatment immediately and consult a healthcare provider.

  Use During Breastfeeding

  • Recommendations: The safety of CinnaTropin during breastfeeding is not well established. Therefore, it is crucial for breastfeeding mothers to consult their healthcare provider before using this medication.
  • Potential Risks: It is not known how much somatropin may pass into breast milk, and its effects on a nursing infant are unclear. Caution is advised, and alternative treatments may be considered.

  Risks of Taking Cinnarizine During Pregnancy

  1. General Recommendation: Cinnarizine is generally not advised for use during pregnancy. It is important to consult with a healthcare provider for safer alternatives.
  2. Potential Effects on Fetus: While specific studies on the effects of cinnarizine during pregnancy are limited, the lack of safety data raises concerns about its use. As a precaution, it is better to avoid medications that have not been thoroughly studied in pregnant populations.
  3. Drowsiness: Cinnarizine is an antihistamine that can cause drowsiness, which may pose risks for pregnant women in terms of alertness and safety.
  4. Consultation Required: Pregnant women or those planning to become pregnant should discuss their medication options with their doctor or pharmacist to ensure the safety of both mother and fetus.

  CinnaTropin: Dosage, Storage, and Reviews

  Dosage

  CinnaTropin is available in two formulations:

  • 5 mg/1.5 ml
  • 10 mg/1.5 ml

  The specific dosage will be prescribed by a healthcare provider based on the individual’s condition and response to treatment. It is typically administered via subcutaneous injection.

  Storage

  Proper storage of CinnaTropin is crucial for maintaining its efficacy:

  • Refrigeration: Store unopened CinnaTropin pens in a refrigerator between 2°C and 8°C (36°F to 46°F).
  • Avoid Freezing: Do not freeze CinnaTropin.
  • Light Protection: Keep the pen away from direct light.
  • Post-Opening Use: After opening, CinnaTropin can be stored:
    • In the refrigerator (2°C to 8°C) for up to 4 weeks.
    • At room temperature (no warmer than 25°C or 77°F) for up to 3 weeks.
  • Expiration: Do not use CinnaTropin after the expiration date printed on the carton and the pen.

  Reviews

  While specific user reviews from the search results were not detailed, general feedback on CinnaTropin indicates:

  • Efficacy: Many users report positive outcomes in terms of growth and metabolic benefits, particularly in pediatric patients with growth hormone deficiencies.
  • Side Effects: Some users have experienced side effects such as edema, headache, and injection site reactions, which are common with growth hormone treatments.
  • Availability: CinnaTropin is available in various markets, including Pakistan, and is often noted for its quality and effectiveness compared to other brands.