Description

Marevan 5mg tablets contain 5mg of warfarin sodium as the active ingredient. Warfarin is an anticoagulant medication, sometimes called a “blood thinner”, that reduces the clotting ability of blood.Marevan 5mg tablets are used to prevent and treat blood clots that can form in the legs, lungs, brain or heart. They come in packs of 100 tablets.The tablets are pink, flat, circular, bevel-edged uncoated tablets with “M” breakline “5” on one side and plain on the other side. They are packaged in plastic pots or aluminum foil blister packs.The typical maintenance dose for adults is 3 to 9mg taken at the same time each day, with the exact dose tailored based on coagulation test results. Dosage may need to be lowered for elderly patients.                                                                                                                                       

Warfarin Formulation

• Marevan contains the sodium salt of warfarin as the active ingredient, rather than the free acid form.
• This sodium salt formulation may have slightly different pharmacokinetic properties compared to other warfarin products.

Tablet Appearance

• The distinctive pink color and “M 5” imprint on the tablets helps identify them as the Marevan brand.
• The bevel-edged, uncoated tablet design is unique to this product.

Packaging Options

• Marevan 5mg tablets are available in both plastic pots and aluminum foil blister packs.
• The blister pack option provides individual dose packaging for improved convenience and compliance.

Dosing Considerations

• The typical maintenance dosage range of 3-9mg per day for Marevan is on the higher end compared to some other warfarin products.
• Careful dose titration and monitoring is required, especially when initiating or changing warfarin therapy.                                                                                                                        Mechanism of action                                                                                                                    Marevan 5mg tablets contain the active ingredient warfarin sodium, which is a synthetic anticoagulant that acts by interfering with the formation of active clotting factors II, VII, IX and X in the liver.Warfarin inhibits the vitamin K-mediated gamma-carboxylation of precursor clotting factors, thereby reducing their activity. Full anticoagulant effect is not achieved until existing circulating clotting factors are removed by normal catabolism, which occurs at different rates for each factor.Warfarin has no direct thrombolytic effect, but by reducing clotting factor activity, it prevents the formation of new harmful blood clots and allows the body’s natural clot-dissolving mechanisms to break down existing clots.The anticoagulant effect of warfarin is monitored by measuring the prothrombin time (PT) or international normalized ratio (INR) and the dose is adjusted to maintain the desired level of anticoagulation.                                                                                                                   
  

  Warfarin

  Anticoagulant medication

  More

  Usage

  Prevents blood clots in the circulatory system, protecting against stroke, deep vein thrombosis, and pulmonary embolism.

  Method of Action

  Decreases blood clotting by inhibiting the enzyme vitamin K epoxide reductase, affecting clotting factors II, VII, IX, and X.

  Administration

  Can be taken orally or administered intravenously.

  Chemical Structure of Warfarin Sodium

  Warfarin sodium has the molecular formula C19H15NaO4 and a molecular weight of 330.31 g/mol. The chemical structure consists of:

  • A 4-hydroxycoumarin ring system
  • A phenyl group attached to the 3-position of the coumarin ring
  • A 2-oxobutyl group attached to the phenyl ring
  • A sodium carboxylate group at the 4-position of the coumarin ring

  The IUPAC name is sodium 2-oxo-3-(3-oxo-1-phenylbutyl)-2H-chromen-4-olate.The structural formula can be written as:

  CC(=O)CC(c1ccccc1)c2c(c3ccccc3oc2=O)[O-].[Na+]


  The InChI representation is:

  InChI=1S/C19H16O4.Na/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22;/h2-10,15,21H,11H2,1H3;/q;+1/p-1


  The SMILES string is:

  CC(=O)CC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)[O-].[Na+]


  Warfarin sodium is a chiral compound containing an equal mixture of (R) and (S) enantiomers, with the (S)-form being more potent and pharmacologically active.                 

  Key Benefits of Marevan 5mg Tablets

  • Reduces the clotting ability of blood to prevent and treat harmful blood clots forming in the legs, lungs, brain or heart
  • Helps prevent systemic embolism in patients with rheumatic heart disease and atrial fibrillation
  • Provides anticoagulant prophylaxis after insertion of prosthetic heart valves

  Key Ingredients

  The active ingredient in Marevan 5mg tablets is warfarin sodium, which is a synthetic anticoagulant that acts by interfering with the formation of active clotting factors II, VII, IX and X in the liver.Each tablet contains 5mg of warfarin sodium. The excipients include:

  • Lactose monohydrate
  • Magnesium stearate
  • Maize starch

  The tablets are pink, flat, circular, bevel-edged uncoated tablets with “M” breakline “5” on one side and plain on the other side. They are packaged in plastic pots or aluminum foil blister packs.                                                                                                                                     

  Key Benefits of Marevan 5mg Tablets

  • Reduces the clotting ability of blood to prevent and treat harmful blood clots forming in the legs, lungs, brain or heart
  • Helps prevent systemic embolism in patients with rheumatic heart disease and atrial fibrillation
  • Provides anticoagulant prophylaxis after insertion of prosthetic heart valves

  Key Ingredients

  The active ingredient in Marevan 5mg tablets is warfarin sodium, which is a synthetic anticoagulant that acts by interfering with the formation of active clotting factors II, VII, IX and X in the liver.Each tablet contains 5mg of warfarin sodium. The excipients include:

  • Lactose monohydrate
  • Magnesium stearate
  • Maize starch

  The tablets are pink, flat, circular, bevel-edged uncoated tablets with “M” breakline “5” on one side and plain on the other side. They are packaged in plastic pots or aluminum foil blister packs.