Description

Ventoxen 100mg is a prescription medication used to treat certain types of chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). It is an oral tablet that is typically taken once daily with food.The key points about Ventoxen 100mg 60’ct tablet are:

• It contains the active ingredient venetoclax, which is a B-cell lymphoma-2 (BCL-2) inhibitor that helps kill cancer cells.
• Ventoxen is approved to be used alone or in combination with other cancer medications like rituximab or obinutuzumab to treat CLL and SLL.
• It can also be used in combination with other chemotherapy drugs like azacytidine, decitabine, and cytarabine to treat acute myeloid leukemia (AML) in certain patients.
• Patients need to take precautions when starting Ventoxen, as it can cause serious side effects like tumor lysis syndrome, especially at the beginning of treatment. Patients must stay hydrated and follow dosing instructions carefully.
• Ventoxen tablets should be swallowed whole and not split, crushed or chewed. Missed doses should be taken as soon as possible within 8 hours, but not if more than 8 hours have passed.
• Common side effects include low white blood cell count, diarrhea, nausea, fatigue, and upper respiratory tract infections.                                                                                                                       
  

  Product Information

  • Product Name: Ventoxen
  • Strength: 100mg
  • Quantity: 60 tablets
  • Imported: Yes

  Indications

  • Chronic Lymphocytic Leukemia (CLL)
  • Small Lymphocytic Lymphoma (SLL)

  Mechanism of Action

  • B-cell Lymphoma-2 (BCL-2) Inhibitor
  • Helps Kill Cancer Cells

  Administration

  • Oral Tablet
  • Take with Food
  • Swallow Whole, Do Not Split, Crush, or Chew

  Precautions

  • Tumor Lysis Syndrome
  • Stay Hydrated
  • Follow Dosing Instructions Carefully

  Common Side Effects

  • Low White Blood Cell Count
  • Diarrhea
  • Nausea
  • Fatigue
  • Upper Respiratory Tract Infections

  Important Information

  • Missed Doses: Take as soon as possible within 8 hours, but not if more than 8 hours have passed.
  • Combination Therapy: Can be used with other cancer medications like rituximab or obinutuzumab to treat CLL and SLL, or with chemotherapy drugs like azacytidine, decitabine, and cytarabine to treat acute myeloid leukemia (AML) in certain patients.

  Key Benefits of Ventoxen 100mg

  • Treats chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL)
  • Can be used alone or in combination with other cancer medications like rituximab or obinutuzumab
  • Also used in combination with chemotherapy drugs like azacytidine, decitabine, and cytarabine to treat acute myeloid leukemia (AML) in certain patients
  • Helps kill cancer cells by blocking the action of certain proteins responsible for cancer cell growth

  Key Ingredients of Ventoxen 100mg

  • Active Ingredient: Venetoclax
  • Venetoclax is a B-cell lymphoma-2 (BCL-2) inhibitor that helps slow or stop the growth of cancer cells

  Mechanism of Action: Targeted Therapy with Venetoclax

  • Ventoxen 100mg and Ventoxen 10mg both utilize the active ingredient venetoclax, which is a selective inhibitor of the B-cell lymphoma 2 (BCL-2) protein.
  • BCL-2 is a protein that plays a key role in regulating cell survival. By inhibiting BCL-2, venetoclax disrupts the survival mechanisms of cancer cells, leading to the induction of apoptosis (programmed cell death).
  • This targeted approach to inhibiting BCL-2 results in the efficient eradication of malignant B-cell lineage cells, such as those found in chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML), while helping to conserve healthy cells.
  • The mechanism of action of venetoclax is particularly beneficial for patients with certain genetic abnormalities like the 17p deletion or TP53 mutation, which are associated with certain hematologic cancers.

  Mechanism of Action: Targeting the BCL-2 Protein

  1. BCL-2 Protein: BCL-2 is an anti-apoptotic protein that plays a crucial role in regulating cell survival and preventing programmed cell death (apoptosis) in cancer cells.
  2. Venetoclax Binding: Venetoclax is a selective inhibitor that binds to the BCL-2 protein, disrupting its function.
  3. Release of Pro-Apoptotic Proteins: By inhibiting BCL-2, venetoclax allows pro-apoptotic proteins like BAX and BIM to be released from BCL-2.
  4. Induction of Apoptosis: The released pro-apoptotic proteins then trigger a cascade of events that lead to the induction of apoptosis, or programmed cell death, in the cancer cells.
     
     

     Chemical Structure of Venetoclax

     The chemical structure of venetoclax can be summarized as follows:

     • Molecular Formula: C45H50ClN7O7S
     • Molecular Weight: 868.44 g/mol
     • IUPAC Name: 4-(4-{[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl}-1-piperazinyl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide

     The key structural features of venetoclax include:

     • A chlorophenyl group
     • A dimethylcyclohexene ring
     • A piperazine moiety
     • A nitrophenyl sulfonamide group
     • A pyrrolo[2,3-b]pyridine group
     • A tetrahydropyran group

     

     

     

     Dosage

     • Ventoxen 100mg is taken once daily with a meal and water
     • The dose is gradually increased over the first 5 weeks for CLL/SLL or first 3-4 days for AML
     • Swallow tablets whole, do not split, chew or crush
     • If a dose is missed by less than 8 hours, take it right away. If more than 8 hours, skip and take next dose at regular time
     • Do not take a double dose to make up for a missed one

     Storage

     • Store below 30°C in a dry place
     • Keep out of reach of children
     • Dispose of unused medication properly, do not flush down toilet

     Reviews

     • No reviews available for Ventoxen 100mg specifically
     • Venetoclax (the active ingredient) has been well-studied in clinical trials for CLL and AML
     • Common side effects include low blood counts, diarrhea, nausea, fatigue, and infections
     • Patients should report any unusual symptoms to their doctor

     some dietary restrictions to be aware of when taking Ventoxen (venetoclax):

     Avoid Grapefruit and Seville Oranges

     • Do not eat grapefruit, Seville oranges (used in some marmalades), or drink grapefruit juice while taking Ventoxen.
     • These fruits can increase the levels of venetoclax in your body, leading to more side effects.

     Take with Food

     • Ventoxen should be taken with a meal and water once daily.
     • Taking it with food helps with absorption and reduces side effects.

     Stay Hydrated

     • Drink at least 6-8 glasses (48-64 oz) of water per day for 2 days before and on the day of your first dose, and each time your dose is increased.
     • This helps reduce the risk of tumor lysis syndrome, a serious complication that can occur when starting treatment.

     Avoid Alcohol

     • While not specifically mentioned in the search results, it’s generally recommended to avoid or limit alcohol intake during cancer treatment to reduce side effects and interactions.

     Precautions with Ventoxen

     Tumor Lysis Syndrome (TLS) Risk

     • Ventoxen can cause a rapid reduction in tumor cells, which poses a risk of tumor lysis syndrome (TLS), especially when starting treatment and during dose increases.
     • To reduce TLS risk, patients should drink 6-8 glasses (48-64 oz) of water per day for 2 days before and on the day of the first dose, and with each dose increase.
     • Close monitoring and hydration is critical, especially at treatment initiation and during dose titration.

     Interactions with Strong CYP3A4 Inhibitors

     • Concomitant use of Ventoxen with strong CYP3A4 inhibitors is contraindicated during the initiation and dose titration phase, as it can increase venetoclax exposure and toxicity.

     Avoid Live Vaccines

     • Live vaccines should not be administered during Ventoxen treatment, as the safety and efficacy have not been established.

     Monitoring

     • Patients should be closely monitored for signs of tumor lysis syndrome, cytopenias, and other adverse reactions, especially during the initial dose titration phase.

     Precautions During Pregnancy

     1. Verify Pregnancy Status: Before starting treatment, your doctor will need to confirm your pregnancy status. This is crucial to ensure that you are not pregnant or planning to become pregnant during treatment.
     2. Avoid Pregnancy: You should not become pregnant while taking Ventoxen. The medication may cause fetal harm, and your doctor will advise you on reliable forms of birth control to use during treatment and for at least 30 days after the last dose.
     3. Monitoring: Your doctor will closely monitor your pregnancy and the fetus during treatment. Regular prenatal check-ups are essential to ensure the health of both you and your unborn child.
     4. Breastfeeding: Ventoxen is not recommended during breastfeeding. The medication may pass into breast milk and potentially harm the baby. You should not breastfeed while taking Ventoxen and for at least one week after the last dose.
     5. Immunizations: Avoid live vaccines during treatment. Your doctor will advise on the best vaccination schedule to ensure your health and the health of your baby.
     6. Other Medications: Inform your doctor about all medications you are taking, including prescription and nonprescription drugs, as well as herbal products. This is crucial to ensure safe and effective treatment.
     7. Tumor Lysis Syndrome (TLS): Ventoxen can cause TLS, which is a condition where cancer cells rapidly break down, leading to kidney failure and other complications. Your doctor will monitor you closely for TLS, especially during the initial dose titration phase.

     Precautions During Breastfeeding

     1. Avoid Breastfeeding: Ventoxen is not recommended during breastfeeding. The medication may pass into breast milk and potentially harm the baby.
     2. Monitoring: Your doctor will closely monitor your baby’s health and development during treatment. Regular check-ups are essential to ensure the baby’s health and well-being.
     3. Immunizations: Avoid live vaccines during treatment. Your doctor will advise on the best vaccination schedule to ensure your baby’s health.
     4. Other Medications: Inform your doctor about all medications you are taking, including prescription and nonprescription drugs, as well as herbal products. This is crucial to ensure safe and effective treatment.

     Precautions During Treatment

     1. Dose Titration: Your doctor will gradually increase your dose over the first 5 weeks for CLL/SLL or the first 3-4 days for AML. This is crucial to manage side effects and ensure effective treatment.
     2. Monitoring: Your doctor will closely monitor your health and the effectiveness of treatment. Regular check-ups are essential to ensure the best possible outcomes.
     3. Side Effects: Inform your doctor immediately if you experience any side effects, including vomiting, nausea, diarrhea, or other symptoms. Your doctor will adjust your treatment plan as needed to manage side effects.

     Summary

     Ventoxen is a powerful medication for treating certain blood cancers, but it requires careful consideration during pregnancy and breastfeeding. It is crucial to follow your doctor’s advice and take necessary precautions to ensure the health and well-being of both you and your baby. Always consult your doctor before starting treatment with Ventoxen.