Mechanism of Action of Votrient (Pazopanib)

Votrient (pazopanib) is a multi-tyrosine kinase inhibitor that works by blocking the activity of several growth factor receptors involved in tumor growth and angiogenesis (blood vessel formation):Inhibits Vascular Endothelial Growth Factor Receptors (VEGFRs)

• Pazopanib inhibits the activity of VEGFR-1, VEGFR-2, and VEGFR-3, which are involved in the formation of new blood vessels that feed tumor growth.

Inhibits Platelet-Derived Growth Factor Receptors (PDGFRs)

• Pazopanib also inhibits the activity of PDGFR-α and PDGFR-β, which regulate cell growth and division.

Inhibits Other Kinases

• In addition, pazopanib inhibits the activity of other kinases such as c-Kit, FGFR-1 and FGFR-3, which are implicated in tumor cell proliferation.
  
  Key Precautions with Votrient 200mg 30-Tablet

  Liver Damage Warning

  • Votrient can cause severe liver damage, including death. Liver function tests should be done before and during treatment to monitor for liver problems. 

  Avoid Grapefruit Juice

  • Consumption of grapefruit juice should be avoided while taking Votrient as it may increase the risk of side effects. 

  Pregnancy and Breastfeeding

  • Votrient is unsafe to use during pregnancy as it may harm the developing baby. It is also unsafe to use while breastfeeding as the drug may cause toxicity to the baby. 

  Driving and Operating Machinery

  • Votrient may cause side effects like dizziness, fatigue and vision problems that can affect the ability to drive or use machines. Do not drive or use machines if experiencing these symptoms. 

  Interactions with Other Medications

  • Votrient may interact with certain other drugs. Inform your doctor about all medicines you are taking before starting Votrient. 

  Monitoring During Treatment

  • Periodic blood tests to check liver, kidney and heart function, blood cell levels and blood pressure will be required before and during Votrient treatment. 

  Dietary Restrictions with Votrient 200mg

  Avoid Grapefruit and Grapefruit Juice

  • Consumption of grapefruit or grapefruit juice should be avoided while taking Votrient, as it may increase the amount of Votrient in the body and increase the risk of side effects.

  Take on an Empty Stomach

  • Votrient should be taken at least 1 hour before or 2 hours after a meal. It should not be taken with food.

  Avoid Alcohol

  • The search results do not provide a definitive answer on whether it is safe to consume alcohol while taking Votrient. It is recommended to consult your doctor before drinking alcohol while on this medication.

  Votrient 200mg 30-tablet has several medication restrictions and precautions that patients should be aware of:

  1. Avoid Grapefruit Juice: Consumption of grapefruit juice should be avoided while taking Votrient as it may increase the risk of side effects.
  2. Avoid Alcohol: It is not known whether it is safe to consume alcohol with Votrient 200mg Tablet. Patients should consult their doctor before drinking alcohol.
  3. Avoid Certain Foods: Patients should ask their doctor about any additional foods they should avoid while taking Votrient.
  4. Do Not Take with Food: Votrient should be taken on an empty stomach. It should not be taken with food and should be taken at least 1 hour before or 2 hours after a meal.
  5. Monitor Liver Function: Votrient can cause severe liver damage, so liver function tests should be done before and during treatment to monitor for liver problems.
  6. Monitor Kidney Function: Votrient is safe to use in patients with kidney disease, but liver function should still be monitored.
  7. Avoid in Liver Disease: Votrient should be used with caution in patients with liver disease. Dose adjustment may be needed, and it is not advised for patients with moderate to severe liver disease.
  8. Avoid in Heart Disease: Patients with heart disease should consult their doctor before taking Votrient.
  9. Avoid in Lung Disease: Patients with a history of lung collapse should consult their doctor before taking Votrient.
  10. Avoid in Pregnancy and Breastfeeding: Votrient is unsafe to use during pregnancy and breastfeeding. It may harm the developing baby.
  11. Avoid in Children: Votrient is not recommended for children and adolescents below 18 years of age.
  12. Avoid in Elderly Patients: While Votrient can be used in elderly patients, it is advisable to consult a doctor before taking it.

  Dosage

  • Recommended Dosage: The recommended dosage of Votrient is 800mg (four 200mg tablets) taken orally once daily without food. It should be taken at least 1 hour before or 2 hours after a meal.
  • Dose Adjustments: The dosage may need to be modified for patients with liver impairment or those taking certain concomitant drugs.

  Storage

  • Storage Conditions: Votrient should be stored at room temperature. It should be kept in a secure location where it will not be exposed to excessive heat, moisture, or direct sunlight.
  • Disposal: Any leftover portion of the medication should be disposed of safely.

  Reviews and Side Effects

  • Side Effects: Common side effects of Votrient include headache, nausea, vomiting, and stomach pain. It can also cause severe liver damage, including death, and requires regular monitoring of liver function.
  • Warnings: Patients should avoid grapefruit and grapefruit juice during treatment as it may increase the risk of side effects. Votrient should not be taken with food and should be taken on an empty stomach.
  • Interactions: Votrient may interact with other medications, including antibiotics, antidepressants, and medicines for high cholesterol. It is not known whether it is safe to consume alcohol with Votrient, and patients should consult their doctor before drinking alcohol.
  • Monitoring: Patients should undergo regular blood tests to check liver, kidney, and heart function, as well as blood cell levels and blood pressure.

  Safety Precautions

  • Pregnancy and Breastfeeding: Votrient is unsafe to use during pregnancy and breastfeeding. It may harm the developing baby.
  • Driving and Operating Machinery: Patients should not drive or operate machinery if they experience dizziness, fatigue, or vision problems.
  • Kidney and Liver Disease: Votrient is safe to use in patients with kidney disease but should be used with caution in patients with liver disease. Dose adjustments may be necessary.

  Additional Information

  • Use in Children and Elderly: Votrient is not recommended for children and adolescents below 18 years of age. It can be used in elderly patients, but patients should consult their doctor before taking it.
  • Monitoring During Treatment: Patients should attend all regularly scheduled appointments with their doctor to ensure proper monitoring and adjustment of the medication.