Description

Zaroxolyn is a brand name for the diuretic medication metolazone, which is available as a 5mg tablet. The key points about Zaroxolyn 5mg 50-count imported tablets are:

• Zaroxolyn is a diuretic/saluretic/antihypertensive drug that belongs to the quinazoline class of medications.
• Metolazone, the active ingredient in Zaroxolyn, works by interfering with the renal tubular mechanism of electrolyte reabsorption, primarily inhibiting sodium reabsorption.
• Zaroxolyn tablets contain 5mg of metolazone and also include inactive ingredients like magnesium stearate, microcrystalline cellulose, and dyes.
• Zaroxolyn is an imported product, likely from Canada based on the information provided.
• The diuretic effects of Zaroxolyn typically begin within one hour and can last for 24 hours or more. The dosage can be adjusted to achieve the desired therapeutic effect.
• Zaroxolyn should not be interchanged with other metolazone formulations that have different bioavailability profiles, as they are not therapeutically equivalent.
  

  Active Ingredient

  Metolazone, a quinazoline diuretic, is the active ingredient in Zaroxolyn 5mg tablets. It works by inhibiting sodium reabsorption in the renal tubular mechanism.

  Dosage Form

  Zaroxolyn is available as a 5mg tablet, with each tablet containing 5mg of metolazone. The tablets also include inactive ingredients such as magnesium stearate, microcrystalline cellulose, and dyes.

  Origin

  The Zaroxolyn 5mg 50-count tablets are an imported product, likely from Canada based on the information provided.

  Therapeutic Effects

  Zaroxolyn has diuretic, saluretic, and antihypertensive properties. Its diuretic effects typically begin within one hour and can last for 24 hours or more.

  Dosage Adjustment

  The dosage of Zaroxolyn can be adjusted to achieve the desired therapeutic effect, as determined by the prescribing healthcare professional.

  Bioavailability Considerations

  Zaroxolyn should not be interchanged with other metolazone formulations that have different bioavailability profiles, as they are not therapeutically equivalent.

  Key Benefits of Zaroxolyn 5mg (Metolazone) Tablets

  Diuretic and Antihypertensive Effects:

  • Zaroxolyn is a diuretic medication that helps the body eliminate excess fluid and sodium, making it effective for treating fluid retention (edema) and high blood pressure (hypertension).
  • The diuretic effects of Zaroxolyn typically begin within one hour and can last for 24 hours or more, allowing for once-daily dosing.

  Efficacy in Patients with Reduced Kidney Function:

  • Unlike thiazide diuretics, Zaroxolyn may produce diuresis in patients with glomerular filtration rates below 20 mL/min, making it a useful option for those with impaired kidney function.

  Synergistic Effects with Loop Diuretics:

  • Zaroxolyn administered concurrently with loop diuretics like furosemide has produced marked diuresis in some patients where edema or ascites was refractory to treatment with maximum recommended doses of these diuretics alone.

  Key Ingredients in Zaroxolyn 5mg Tablets

  Active Ingredient:

  • The active ingredient in Zaroxolyn 5mg tablets is 5mg of metolazone, a quinazoline diuretic.

  Inactive Ingredients:

  • The inactive ingredients include magnesium stearate, microcrystalline cellulose, and dyes (D&C Red No. 33 for the 2.5mg tablets and FD&C Blue No. 2 for the 5mg tablets).

  Zaroxolyn (metolazone) can be used to treat edema (fluid retention) in the following ways:

  • Zaroxolyn is a diuretic medication that helps the body eliminate excess fluid and sodium, making it effective for treating fluid retention (edema) in conditions like congestive heart failure and nephrotic syndrome.

   

  • The diuretic effects of Zaroxolyn typically begin within one hour and can last for 24 hours or more, allowing for once-daily dosing to manage edema.

   

  • Zaroxolyn may be particularly useful for treating edema in patients with reduced kidney function, as it can produce diuresis even when glomerular filtration rates are below 20 mL/min, unlike thiazide diuretics.

   

  • When used concurrently with loop diuretics like furosemide, Zaroxolyn can produce marked diuresis in some patients where edema or ascites was refractory to treatment with maximum recommended doses of the loop diuretics alone.

  Metolazone, the active ingredient in Zaroxolyn, has the following mechanism of action:

  • Metolazone is a thiazide-like diuretic that interferes with the renal tubular mechanism of electrolyte reabsorption.
  • It acts primarily to inhibit sodium reabsorption at the cortical diluting site and to a lesser extent in the proximal convoluted tubule.
  • Sodium and chloride ions are excreted in approximately equivalent amounts.
  • The increased delivery of sodium to the distal tubular exchange site results in increased potassium excretion.
  • Metolazone does not inhibit carbonic anhydrase.
  • A proximal action of metolazone has been shown by increased excretion of phosphate and magnesium ions and by a markedly increased fractional excretion of sodium in patients with severely compromised glomerular filtration.

  

  

  Metolazone

  Thiazide-like diuretic used for treating congestive heart failure and high blood pressure

  More

  Primary Uses

  Treats congestive heart failure and high blood pressure by reducing water reabsorption in the kidneys

  Advantage Over Other Diuretics

  Remains active in treating fluid retention even in moderate chronic kidney disease

  Combination Therapy

  Used in combination with loop diuretics to enhance diuresis in heart failure and kidney disease

  Metolazone, the active ingredient in Zaroxolyn, has the following chemical structure:

  • The IUPAC name of metolazone is 7-chloro-2-methyl-4-oxo-3-o-tolyl-3,4-dihydroquinazoline-6-sulfonamide with the molecular formula C16H16ClN3O3S.
  • Metolazone is a quinazoline derivative, similar to the diuretic quinethazone.
  • The molecular structure consists of a quinazoline ring system with a chloro group at position 7, a methyl group at position 2, a tolyl group at position 3, and a sulfonamide group at position 6.
  • Metolazone is a colorless crystalline solid with a melting point of 255-257°C.

  

  

  

  Dosage

  The effective dosage of Zaroxolyn (metolazone) should be individualized based on the patient’s condition and response to treatment. The usual dosage ranges are:

  • Edema of cardiac failure: 5-20 mg once daily
  • Edema of renal disease: 5-20 mg once daily
  • Mild to moderate hypertension: 2.5-5 mg once daily

  The dosage may need to be adjusted based on the patient’s response and any concurrent use of other antihypertensive drugs or diuretics.

  Storage

  Zaroxolyn tablets should be stored at room temperature, between 68°F to 77°F (20°C to 25°C). They should be protected from light and moisture, and kept out of reach of children.The tablets should be dispensed in tight, light-resistant containers. Patients should be advised not to store the medication in the bathroom, as the humidity can degrade the tablets.

  Patient Reviews

  Based on reviews from patients taking Zaroxolyn:

  • Many patients report that Zaroxolyn is effective in reducing fluid retention and swelling associated with heart failure or kidney disease.
  • Some patients note that Zaroxolyn starts working quickly, with diuretic effects within 1 hour of taking the medication.
  • A common side effect reported is increased urination, which is the intended therapeutic effect of the medication.
  • A few patients mention experiencing electrolyte imbalances, dizziness, or other side effects, highlighting the importance of close monitoring by the healthcare provider.
  • Overall, Zaroxolyn seems to be well-tolerated by most patients when used as directed under medical supervision.