Description

Eliquis 5 mg tablets are an anticoagulant medication used to reduce the risk of stroke and blood clots in patients with irregular heartbeat (atrial fibrillation) and to treat and prevent blood clots in the veins, especially in the legs and lungs.The key points about Eliquis 5 mg tablets are:

• Eliquis contains the active ingredient apixaban, which works by inhibiting Factor Xa, a protein involved in blood clotting. This helps prevent clot formation and improves blood flow.
• The recommended dose is typically one 5 mg tablet taken twice daily, though the dose may be reduced to 2.5 mg twice daily in certain patients.
• Eliquis can be taken with or without food. For patients who cannot swallow the tablets whole, they can be crushed and mixed with water, apple juice, or other liquids.
• Common side effects include nausea, bleeding, and bruising. Patients should seek immediate medical attention for any unusual or prolonged bleeding.
• Eliquis is contraindicated in patients with active bleeding, certain liver diseases, or those taking other anticoagulant medications.
  

  Mechanism of Action

  • Eliquis contains the active ingredient apixaban, which is a direct and selective inhibitor of Factor Xa, a key protein involved in the blood clotting cascade.
  • This targeted mechanism of action is unique compared to older anticoagulants like warfarin that work more broadly.

  Dosing Flexibility

  • Eliquis can be taken with or without food, providing flexibility for patients.
  • The tablets can also be crushed and mixed with liquids if patients have difficulty swallowing whole tablets.
  • Dose can be adjusted down to 2.5 mg twice daily in certain high-risk patients.

  Reduced Monitoring

  • Unlike warfarin, Eliquis does not require regular blood tests to monitor drug levels and adjust the dose.
  • This can simplify treatment management for both patients and healthcare providers.

  Reduced Risk of Bleeding

  • Clinical studies have shown Eliquis has a lower risk of major bleeding compared to other direct oral anticoagulants.
  • This improved safety profile is a key advantage over older anticoagulant options.

  Convenient Twice-Daily Dosing

  • The twice-daily dosing of Eliquis is more convenient than some other anticoagulants that require more frequent administration.
  • This can improve patient adherence and overall treatment effectiveness.
  

  Apixaban

  Anticoagulant medication

  More

  Brand name

  Eliquis

  Used for

  Treating and preventing blood clots, preventing stroke in people with nonvalvular atrial fibrillation

  Administration

  Oral
  Eliquis (apixaban) is a direct and selective inhibitor of Factor Xa, a key protein involved in the blood clotting cascade.By binding reversibly to the active site of Factor Xa, apixaban attenuates thrombin generation, which is essential for clot formation. This targeted mechanism of action helps prevent clot formation and improves blood flow.Unlike older anticoagulants like warfarin that work more broadly, apixaban does not require antithrombin III for its antithrombotic activity. This unique mechanism allows Eliquis to effectively reduce the risk of stroke and blood clots in patients with atrial fibrillation and treat/prevent venous thromboembolism.

  Key Benefits of Eliquis 5 mg

  • Reduces stroke and clot risk
  • Convenient twice-daily dosing
  • Can be taken with/without food
  • Flexible dosing options
  • Lower bleeding risk vs. other anticoagulants

  Key Ingredient

  • Active ingredient is apixaban
  • Direct, selective Factor Xa inhibitor
  • Prevents clot formation

  Eliquis 5 mg Dosage

  • 1 tablet twice daily
  • Dose may be reduced to 2.5 mg twice daily for some patients

  Storage

  • Store at room temperature 20-25°C (68-77°F)
  • Protect from light and moisture
  • Keep away from children

  Patient Reviews

  • Generally positive for preventing clots
  • Convenient twice-daily dosing without monitoring
  • Some minor side effects reported
  • Well-tolerated when used as directed
    

    Chemical Structure of Apixaban

    • The chemical name of apixaban is 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide.
    • Apixaban has the molecular formula C25H25N5O4 and a molar mass of 459.506 g/mol.
    • The chemical structure of apixaban contains a pyrazolo[3,4-c]pyridine core with a 4-methoxyphenyl group, a 4-(2-oxopiperidin-1-yl)phenyl group, and a carboxamide group.
    • Apixaban is a direct and selective inhibitor of Factor Xa, a key protein involved in the blood clotting cascade.
    • The high affinity binding of apixaban to the active site of Factor Xa (Ki = 0.08 nM) is responsible for its anticoagulant and antithrombotic mechanisms of action.