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Amphotericin B 5mg Injection
Amphotericin B 5mg Injection is a medication used to treat serious, potentially fatal fungal infections
Amphotericin B 5mg Injection has several unique features:
- It is a potent antifungal medication used to treat severe, invasive fungal infections when other options are not suitable.
- It is administered by slow intravenous infusion, usually once daily or every other day. The dosage is carefully adjusted based on the patient’s condition, weight, and response to treatment.
- Amphotericin B 5mg Injection contains the active ingredient amphotericin B, which works by disrupting the cell membranes of fungal cells.
- It is formulated as a liposomal drug delivery system, where the amphotericin B is intercalated into a liposomal membrane. This helps reduce some of the side effects compared to traditional amphotericin B formulations.
- Careful monitoring and dosing is required due to the potential for serious side effects like infusion reactions, kidney problems, liver problems, and nerve/muscle effects. Premedication may be given to help prevent infusion reactions.
- Amphotericin B 5mg Injection is intended for severe, potentially life-threatening fungal infections and should not be used for less serious fungal infections in patients with normal white blood cell counts.
Original price was: ₨3,999.00.₨3,500.00Current price is: ₨3,500.00.
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Description
Amphotericin B 5mg Injection is a medication used to treat serious, potentially fatal fungal infections
Amphotericin B 5mg Injection has several unique features:
- It is a potent antifungal medication used to treat severe, invasive fungal infections when other options are not suitable.
- It is administered by slow intravenous infusion, usually once daily or every other day. The dosage is carefully adjusted based on the patient’s condition, weight, and response to treatment.
- Amphotericin B 5mg Injection contains the active ingredient amphotericin B, which works by disrupting the cell membranes of fungal cells.
- It is formulated as a liposomal drug delivery system, where the amphotericin B is intercalated into a liposomal membrane. This helps reduce some of the side effects compared to traditional amphotericin B formulations.
- Careful monitoring and dosing is required due to the potential for serious side effects like infusion reactions, kidney problems, liver problems, and nerve/muscle effects. Premedication may be given to help prevent infusion reactions.
- Amphotericin B 5mg Injection is intended for severe, potentially life-threatening fungal infections and should not be used for less serious fungal infections in patients with normal white blood cell counts.
In summary, the key unique features are its potent antifungal activity, specialized liposomal formulation, need for careful dosing and monitoring, and use only for serious invasive fungal infections.
Key Ingredients:
- Amphotericin B – the active antifungal agent that disrupts fungal cell membranes
- Deoxycholic acid – helps solubilize the amphotericin B
- Sodium phosphate (dibasic and monobasic) – used as a buffer
Key Benefits:
- Treats serious, potentially fatal fungal infections caused by Aspergillus, Candida, Cryptococcus and other fungi
- Formulated as a liposomal drug delivery system to help reduce side effects compared to traditional amphotericin B
- Administered intravenously, usually once daily or every other day
- Dosage is carefully adjusted based on patient’s condition, weight, and response to treatment                                                                  Dosage:
- Usual adult dose is 0.7-1 mg/kg given by slow IV infusion over 4-6 hours, once daily
- Initial dose may be lower (5-10 mg) in certain patients
- Dose gradually increased by 5-10 mg/day to recommended daily dose
- Maximum dose should not exceed 1.5 mg/kg per day due to risk of serious side effects
- Careful monitoring of kidney function required
Preparation and Administration:
- Powder must be reconstituted to 5 mg/mL, then diluted in 500 mL 5% glucose
- Infuse over 2-6 hours, can reduce to 1 hour if well-tolerated
Storage:
- Powder vial refrigerated at 2-8°C
- Concentrated solution stable for 24 hours refrigerated
- Diluted infusion solution must be used immediately
Reviews for Amphotericin B 5mg Injection:
- Average 3.5/5 rating from 7 WebMD reviews
- Effective for severe fungal infections, but risk of side effects
- Dosing challenges and long treatment course noted
- Careful monitoring required
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