Description

Product Details

• Provides 125 micrograms (5000 IU) of vitamin D3 per serving
• Packaged in a bottle of 180 softgel capsules
• Imported supplement, may not be available in all regions

Benefits of Vitamin D

• Supports healthy bones and teeth by aiding calcium absorption
• Can help prevent conditions like osteoporosis
  

  Key Benefits of GNC Vitamin D-3 125mcg 180’s Imported

  • Essential for calcium absorption and strong bones
  • Supports healthy teeth and bones
  • Helps prevent conditions like osteoporosis
  • Provides a 180-day supply

  Key Ingredients

  • Vitamin D-3 (Cholecalciferol) – 125 micrograms (5000 IU) per serving
  • Soybean Oil
  • Gelatin
  • Glycerin
  • Caramel Color

  The primary active ingredient is vitamin D-3 (cholecalciferol) at 125 micrograms (5000 IU) per softgel capsule. This high potency vitamin D supplement supports calcium absorption and overall bone health.                                                                                                                                                       

  Mechanism of Action: How GNC Vitamin D-3 125mcg Supports Bone Health

  The primary mechanism by which GNC Vitamin D-3 125mcg (5000 IU) supports bone health is by facilitating calcium absorption in the intestines. Vitamin D-3 (cholecalciferol) plays a crucial role in this process:

  1. Vitamin D-3 is converted to 25-hydroxyvitamin D (25(OH)D) in the liver.
  2. 25(OH)D is then converted to the active form, 1,25-dihydroxyvitamin D (1,25(OH)2D), primarily in the kidneys.
  3. 1,25(OH)2D binds to vitamin D receptors (VDRs) in the intestines, which increases the expression of calcium-binding proteins.
  4. These proteins facilitate the absorption of calcium from the intestines into the bloodstream.

  By enhancing calcium absorption, vitamin D-3 ensures adequate calcium levels are available for maintaining strong, healthy bones. This is essential for preventing conditions like osteoporosis.In addition to its role in calcium homeostasis, vitamin D-3 also contributes to bone health by:

  • Promoting osteoblast (bone-forming cell) activity and mineralization
  • Inhibiting osteoclast (bone-resorbing cell) formation and activity
  • Supporting overall skeletal muscle function and reducing the risk of falls

  The high potency of 125 micrograms (5000 IU) per softgel capsule helps maintain sufficient vitamin D levels to support these bone-protective mechanisms.                                                                       

  How Vitamin D-3 Supports Overall Skeletal Health

  Vitamin D-3 plays a crucial role in maintaining strong bones and supporting overall skeletal health through several key mechanisms:

  1. Facilitates calcium absorption: Vitamin D-3 enhances intestinal calcium absorption, ensuring adequate calcium levels are available for bone mineralization and maintenance.
  2. Promotes bone formation: Vitamin D-3 stimulates osteoblast (bone-forming cell) activity and mineralization, contributing to the formation of strong, healthy bones.
  3. Inhibits bone resorption: It suppresses osteoclast (bone-resorbing cell) formation and activity, helping to prevent excessive bone loss.
  4. Supports muscle function: Vitamin D-3 is important for maintaining healthy skeletal muscles. Adequate levels may reduce the risk of falls in older adults by improving muscle strength and function.
  5. Prevents conditions like rickets and osteoporosis: By supporting calcium absorption and bone health, vitamin D-3 helps prevent skeletal deformities in children (rickets) and reduces the risk of osteoporosis and fractures in adults.

  Experts recommend a minimum 25-hydroxyvitamin D (25(OH)D) blood level of 32 ng/mL for optimal protection against fractures and maximal calcium absorption. Supplementation with at least 800-1000 IU (20-25 mcg) of vitamin D-3 daily, along with 1000-1200 mg of calcium, is often advised for maintaining overall skeletal health.                                                                                                   

  Vitamin D-3’s Contribution to Brain and Heart Health

  Brain Health Benefits

  • Vitamin D-3 can cross the blood-brain barrier and its receptors are widely distributed in the central nervous system
  • Supplementation with vitamin D-3 improves cognitive performance, particularly attention and memory
  • Vitamin D-3 deficiency may accelerate neuronal degeneration and cognitive defects in conditions like Alzheimer’s disease
  • Vitamin D-3 reduces oxidative stress and prevents neuronal death by promoting the elimination of amyloid-beta plaques
  • Higher levels of vitamin D-3 in the brain are associated with better cognitive function, stronger memory, and slower cognitive decline

  Heart Health Benefits

  • Vitamin D-3 plays a crucial role in maintaining cardiovascular health
  • Deficiency in vitamin D-3 is linked to an increased risk of high blood pressure and other cardiovascular diseases
  • Adequate vitamin D-3 levels help regulate calcium homeostasis, which is important for proper heart function
  • Vitamin D-3 has anti-inflammatory properties that may contribute to cardiovascular health
  • Supplementation with vitamin D-3 may help improve heart function in individuals with vitamin D deficiency

  Key Precautions and Dietary Restrictions

  • No sugar, starch, preservatives, wheat, or dairy 
  • Gluten-free 
  • No artificial colors or flavors 
  • This product is not intended to diagnose, treat, cure, or prevent any disease 
  • Ensure you follow the recommended dosage instructions on the product label 

  key points about potential interactions between Vitamin D-3 and other medications:

  Potential Interactions with Vitamin D-3

  The search results indicate that Vitamin D-3 (cholecalciferol) can interact with a number of common medications, including:Medications that may increase Vitamin D-3 levels:

  • Estrogen (hormone replacement therapy)
  • Isoniazid (tuberculosis medication)
  • Thiazide diuretics (e.g. hydrochlorothiazide)

  Medications that may decrease Vitamin D-3 levels or absorption:

  • Antacids
  • Calcium channel blockers (e.g. verapamil)
  • Cholestyramine (cholesterol medication)
  • Anticonvulsants (e.g. phenobarbital, phenytoin)
  • Mineral oil
  • Weight loss products containing orlistat or olestra

  Vitamin D Supplementation During Pregnancy and Breastfeeding

  Vitamin D is crucial for both the mother and the developing baby during pregnancy. It plays a vital role in calcium absorption, bone health, and immune function. Adequate vitamin D levels are also important for the baby’s growth and development.

  Benefits of Vitamin D During Pregnancy

  • Supports healthy bone development in the fetus
  • Reduces the risk of preeclampsia, gestational diabetes, and preterm birth
  • Lowers the risk of childhood asthma and wheezing in offspring
  • Helps maintain the mother’s bone health and prevent osteoporosis

  Recommended Vitamin D Intake During Pregnancy

  • Recent studies suggest pregnant women may need 4,000-6,000 IU of vitamin D3 daily to achieve sufficiency
  • The average prenatal vitamin only contains 400 IU of vitamin D, so additional supplementation is often necessary
  • Factors like obesity, limited sun exposure, and malabsorption disorders can increase the risk of deficiency

  Vitamin D and Breastfeeding

  • Breastfed infants of vitamin D deficient mothers are at risk of developing deficiency and associated health issues
  • Maternal vitamin D status during pregnancy and lactation determines the vitamin D content of breastmilk
  • Breastfeeding mothers may need 6,000-10,000 IU of vitamin D3 daily to provide sufficient vitamin D to their infants through breastmilk

  Dosage

  • The recommended dosage for this GNC Vitamin D-3 supplement is 1 softgel capsule (125 mcg or 5000 IU) per day.

  Storage

  • The search results indicate this product should be stored at room temperature, away from direct heat, moisture, and sunlight.
  • Proper storage helps maintain the potency and effectiveness of the vitamin D-3 supplement.

  Reviews

  The reviews for this GNC Vitamin D-3 supplement are generally positive:

  • Customers report it is a “great supplement” and “one of the best vitamin D3 you can take”
  • Many users say it has helped improve their immune system and overall health
  • Some long-time users mention their parents have been taking this brand for years and are satisfied with it
  • The product is described as being of high quality and matching the description
  • Customers appreciate the availability of this hard-to-find 5000 IU vitamin D-3 supplement