Description

Largactil 25mg Tab 40’ct is a medication containing the active ingredient chlorpromazine hydrochloride. It is a typical antipsychotic drug used in the treatment of various mental health conditions, including:

• Schizophrenia and other psychoses (especially where paranoia is a predominant symptom), mania and hypomania
• Anxiety, psychomotor agitation, excitement, violent or dangerously impulsive behavior
• Intractable hiccup
• Nausea and vomiting in terminal illness (where other drugs have failed or are not available)

The recommended adult dosage for these conditions is typically 25-300 mg daily, taken in divided doses or at bedtime. The dosage may need to be adjusted based on the individual patient’s response.Largactil 25mg tablets should not be crushed, and the injectable solution should be handled carefully to avoid contact dermatitis. Patients should be monitored for potential side effects such as decreased platelet count.

Active Ingredient

The active ingredient in Largactil 25mg Tab 40’ct is chlorpromazine hydrochloride.

Indications

Largactil 25mg Tab 40’ct is used to treat the following conditions:

• Schizophrenia and other psychoses (especially where paranoia is a predominant symptom)
• Mania and hypomania
• Anxiety, psychomotor agitation, excitement, violent or dangerously impulsive behavior
• Intractable hiccup
• Nausea and vomiting in terminal illness (where other drugs have failed or are not available)

Dosage

The recommended adult dosage for these conditions is typically 25-300 mg daily, taken in divided doses or at bedtime. The dosage may need to be adjusted based on the individual patient’s response.

Administration

Largactil 25mg tablets should not be crushed, and the injectable solution should be handled carefully to avoid contact dermatitis.

Monitoring

Patients should be monitored for potential side effects such as decreased platelet count.

Key Benefits of Largactil 25mg Tab 40’ct

Largactil 25mg Tab 40’ct is used to treat the following conditions:

• Schizophrenia and other psychoses (especially where paranoia is a predominant symptom), mania and hypomania
• Anxiety, psychomotor agitation, excitement, violent or dangerously impulsive behavior
• Intractable hiccup
• Nausea and vomiting in terminal illness (where other drugs have failed or are not available)

Key Ingredients

The active ingredient in Largactil 25mg Tab 40’ct is chlorpromazine hydrochloride. Each tablet contains 25 mg of chlorpromazine hydrochloride.The excipients include:

• Lactose monohydrate
• Other excipients (not specified)

Mechanism of Action of Largactil 25mg Tab 40’ct

Largactil 25mg Tab 40’ct contains the active ingredient chlorpromazine hydrochloride, which is a typical antipsychotic drug. It works by blocking the effects of dopamine, a chemical in the brain.Specifically, chlorpromazine blocks dopamine receptors in the brain, particularly the D2 receptors. This reduces the excessive activity of dopamine, which is believed to be involved in the development of psychotic symptoms like delusions and hallucinations.By blocking dopamine receptors, chlorpromazine also affects other neurotransmitter systems in the brain, such as serotonin, norepinephrine, and histamine. This broad mechanism of action contributes to its efficacy in treating various mental health conditions, including schizophrenia, mania, and severe behavioral problems in children.                                                               

How the Ring Structure of Chlorpromazine Affects its Pharmacokinetics

The unique ring structure of chlorpromazine, the active ingredient in Largactil 25mg Tab 40’ct, plays a significant role in its pharmacokinetic properties:Phenothiazine Ring System
Chlorpromazine has a phenothiazine ring structure, consisting of a central six-membered ring fused to two benzene rings . This tricyclic ring system is characteristic of phenothiazine drugs and contributes to their pharmacological effects as typical antipsychotics.Boat Conformation
The central six-membered ring of the phenothiazine structure adopts a boat conformation, as shown in the molecular structure diagrams . This three-dimensional shape influences the binding and interactions of chlorpromazine with its target receptors in the brain.Substitutions
Chlorpromazine has a chlorine atom substituted at the 2-position of the phenothiazine ring . This structural feature affects the pharmacokinetic properties of the drug, including its metabolism and distribution.                                                                                                                                      Metabolic Pathways
The phenothiazine ring structure of chlorpromazine undergoes various metabolic transformations, such as oxidation, hydroxylation, and conjugation . These structural changes can impact the potency and pharmacological activity of the drug’s metabolites, contributing to the overall pharmacokinetic profile.                                                                                                                                                            Phenothiazine Ring System
The phenothiazine ring structure, which is characteristic of chlorpromazine and other phenothiazine drugs, is associated with a number of potential side effects :

• Sedation and drowsiness
• Orthostatic hypotension
• Anticholinergic effects like dry mouth, constipation, and blurred vision
• Photosensitivity and skin discoloration

Metabolic Pathways
The phenothiazine ring structure of chlorpromazine undergoes various metabolic transformations, such as oxidation, hydroxylation, and conjugation . These structural changes can impact the potency and pharmacological activity of the drug’s metabolites, contributing to the overall side effect profile.Substitutions
The chlorine atom substituted at the 2-position of the phenothiazine ring also affects the pharmacokinetic properties of chlorpromazine, which may influence its side effects .             

Dosage

The recommended dosage of Largactil 25mg Tab 40’ct varies depending on the condition being treated and the patient’s age:

• Adult oral dosage: Initially 25 mg three times daily or 75 mg at bedtime, increasing by daily amounts of 25 mg to an effective maintenance dose, usually in the range of 75 to 300 mg daily, but some patients may require up to 1 g daily.
• Children 1-5 years: 0.5 mg/kg bodyweight every 4-6 hours, not to exceed 40 mg daily.
• Children 6-12 years: A third to half the adult dose, not to exceed 75 mg daily.
• Elderly: Start with a third to a half the usual adult dose with a more gradual increase in dosage.

The dosage should be adjusted based on the individual patient’s response to the medication.

Storage

• Keep Largactil tablets in the original pack until it is time to take them.
• Store Largactil tablets in a cool, dry place.
• Do not store Largactil or any other medicine in the bathroom or near a sink.
• Keep Largactil out of reach of children.

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