Description

Product Information

• Brand Name: Tylenol
• Strength: Extra Strength
• Quantity: 200 Caplets
• Country of Origin: Canada
• Imported to: Pakistan

Active Ingredient

• Name: Acetaminophen
• Amount per Caplet: 500 mg

Usage

• Age Group: Adults and children 12 years and older
• Symptoms: Headache, backache, toothache, menstrual cramps, pain caused by the common cold

Important Notes

• Dosage: Follow dosage instructions carefully
• Overdose: Seek immediate medical advice if an overdose occurs
• Medical Conditions: Consult a doctor before taking if you have liver or kidney disease, including alcoholic liver disease, or are on a low sodium diet.                                                                                  Key Benefits of Tylenol Extra Strength
  • Provides fast-acting relief from pain associated with headaches, muscle cramps, and fever symptoms 
  • Can be used by adults and children 12 years and older to help provide relief for common pain symptoms such as headache, backache, toothache, menstrual cramps, and pain caused by the common cold 
  • Does not cause the stomach and intestinal ulcers that NSAIDs such as aspirin, ibuprofen, and naproxen may cause 

  Key Ingredients

  • Active Ingredient: Acetaminophen, 500 mg per caplet 
  • Other Ingredients: benzyl alcohol, butylparaben, carboxymethylcellulose sodium, D&C yellow no. 10, edetate calcium disodium, FD&C blue no. 1, FD&C red no. 40, gelatin, hypromellose, iron oxide, magnesium stearate, methylparaben, modified starch, polyethylene glycol, polysorbate 80, powdered cellulose, pregelatinized starch, propylene glycol, propylparaben, red iron oxide, sodium lauryl sulfate, sodium propionate, sodium starch glycolate, titanium dioxide, yellow iron oxide 

  Mechanism of Action of Acetaminophen (Active Ingredient in Tylenol Extra Strength)Acetaminophen, the active ingredient in Tylenol Extra Strength, is an effective pain reliever and fever reducer. However, its exact mechanism of action is not fully understood. Here’s what we know:Pain Relief

  • Acetaminophen inhibits the synthesis of prostaglandins in the central nervous system, which play a role in pain perception and fever.
  • It may also activate the endogenous opioid system and descending serotonergic pathways to reduce pain.

  Fever Reduction

  • Acetaminophen acts on the hypothalamus to lower the set point of the body’s temperature control center, thereby reducing fever.

  Limitations

  • Unlike NSAIDs like ibuprofen, acetaminophen does not have significant anti-inflammatory effects or ability to reduce swelling.
  • It is not fully clear why acetaminophen is effective for pain relief but lacks anti-inflammatory properties.
  
  The chemical structure of acetaminophen, the active ingredient in Tylenol Extra Strength, is:Chemical Name: N-Acetyl-p-aminophenol
  Structural Formula:

  text

  O
| |
C-NH-COCH3
| |
C6H5


  Physicochemical Properties:

  • Molecular Weight: 151.16
  • Physical Form: White, crystalline powder
  • Solubilities: Soluble in methanol, ethanol, DMF, acetone, ethyl acetate; very slightly soluble in cold, more so in hot, water
  • pH/pKa: 5.4-6.9 (pH of aqueous suspension); pKa: 9.5
  • Melting Range: 168-172 °C.

  

  Precautions

  • Do not take more than 3,000 mg of acetaminophen per 24-hour period, as it can cause serious liver damage .
  • Avoid alcohol use while taking Tylenol Extra Strength, as it can increase the risk of liver damage .
  • Consult a doctor before use if you have liver or kidney disease, as acetaminophen may not be safe for you .
  • Seek immediate medical attention if you experience symptoms of acetaminophen overdose such as nausea, vomiting, loss of appetite, extreme tiredness, or yellowing of the skin/eyes .
  • Discontinue use and seek medical help if a skin rash or allergic reaction occurs, as acetaminophen can cause severe skin reactions .

  Dietary Restrictions

  • Tylenol Extra Strength can generally be taken with or without food .
  • However, it’s best to avoid drinking alcohol while taking this medication, as it can increase the risk of liver damage .
  • No other specific dietary restrictions are noted, but it’s always a good idea to consult your healthcare provider about any potential interactions with your diet or other medications you may be taking.

  Pregnancy

  • Acetaminophen (the active ingredient in Tylenol) is generally considered safe to use during pregnancy when taken as directed.
  • Tylenol Extra Strength and Tylenol Rapid Release Gels are also generally safe during pregnancy, but contain a higher dose of acetaminophen (500 mg per caplet vs 325 mg in regular Tylenol).
  • The recommended dosage for pregnant women is up to 3,000 mg of acetaminophen per day, taken in divided doses of no more than 1,000 mg at a time.
  • Acetaminophen is preferred over NSAIDs like ibuprofen during pregnancy, as NSAIDs have been associated with increased risk of certain birth defects.
  • Pregnant women should consult their doctor before taking any medication, including Tylenol, to ensure it is appropriate for their specific situation.

  Breastfeeding

  • Acetaminophen is considered safe for use while breastfeeding. Only small amounts of the drug pass into breastmilk.
  • The recommended dosage for breastfeeding women is the same as for non-breastfeeding adults – up to 3,000 mg per day in divided doses.
  • Breastfeeding women should consult their doctor before taking any medication to ensure it is safe for their infant.

  Dosage

  • Adults: Take 2 caplets every 6-8 hours as needed for pain relief. Do not take more than 3,000 mg of acetaminophen per day.
  • Children: Use a product specifically designed for children and follow the dosage instructions based on the child’s weight or age. Do not give to children under 12 years of age unless directed by a doctor.

  Storage

  • Room Temperature: Store at room temperature away from light and moisture.
  • Avoid Humidity and Direct Light: Do not store in the bathroom or near heat or open flames.
  • Child-Resistant Packaging: Use a child-resistant container to store the medication.

  Reviews

  • Effectiveness: Tylenol Extra Strength is effective for relieving mild to moderate pain, including headaches, backaches, toothaches, menstrual cramps, and pain caused by the common cold.
  • Safety: It is generally considered safe when taken as directed, but excessive use can cause liver damage. Consult a doctor before taking if you have liver or kidney disease.

  Important Notes

  • Overdose: If you think you or someone else may have taken too much acetaminophen, seek medical attention immediately. Symptoms of overdose include nausea, vomiting, loss of appetite, sweating, stomach/abdominal pain, extreme tiredness, yellowing of the skin/eyes, and dark urine.
  • Pregnancy and Breastfeeding: Acetaminophen is generally safe during pregnancy and breastfeeding, but consult a doctor before taking any medication.

  You should be cautious when taking Tylenol Extra Strength (acetaminophen) with other medications, as there are many potential interactions:

  • Tylenol Extra Strength can interact with 125 different medications, including 8 major interactions, 81 moderate interactions, and 36 minor interactions.
  • Some of the most common interacting medications include propranolol, methotrexate, warfarin, albuterol, amlodipine, aspirin, atorvastatin, ibuprofen, and many others.
  • Acetaminophen can be dangerous when taken with other medications that contain acetaminophen, as it increases the risk of liver damage and acetaminophen overdose.
  • Tylenol Extra Strength may also interact with certain disease states like liver disease, kidney disease, and alcoholic liver disease.
  • Drinking alcohol while taking Tylenol Extra Strength can increase the risk of liver damage.

  To avoid interactions, it’s important to:

  • Check the active ingredients in all your medications to avoid taking multiple acetaminophen-containing products.
  • Consult your doctor or pharmacist before taking Tylenol Extra Strength, especially if you are taking other medications or have certain medical conditions.
  • Do not exceed the recommended dosage of 3,000 mg of acetaminophen per day, as higher doses increase the risk of liver toxicity.